Zinc and copper replacement therapy in children with deep burns

Pochon, J. P.; Klöti, J.

doi:10.1016/0305-4179(78)90057-8

Cited by 9 publications

(7 citation statements)

References 16 publications

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“…The intravenous route is the only one that guaranties bioavailability in the circulating compartment, avoiding the absorption problems and the liver firstpass effect. The clinical trials that have used the enteral route in the critically ill are few (burns [34], trauma [25]). This is explained by the unpredictable Key Micronutrients in the ICU absorption in the critically ill [35], and the difficulty in guarantying full enteral delivery very early on during the course of acute illness.…”

Section: Route Of Deliverymentioning

confidence: 99%

“…In addition many micronutrients compete for enteral absorption, such as copper and zinc, selenium and copper, and many others. These interactions may compromise the therapeutic intervention as observed for copper and zinc during a supplementation trial carried out in burned children, where enteral supplementation failed to correct copper and zinc deficiency [34]. Moreover, providing micronutrients by the enteral route after bowel surgery does not increase the circulating levels [38].…”

Section: Route Of Deliverymentioning

confidence: 99%

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Key Vitamins and Trace Elements in the Critically Ill

Berger

Chioléro²

2003

Nutrition and Critical Care

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Table 1. ICU conditions at risk of endogenous antioxidant depletion Condition ⇑ ROS production Vitamin and trace elements ⇑ degradation products at risk or depleted Acute illness Lipoperoxides, plasma Vitamin B1 [19] redox status [a] Ascorbic acid [b] Acute coronary syndrome TBARS [c] Selenium [d] Acute renal failure TBARS [e] Selenium, ascorbic acid, and ␤-carotene [f] Copper, Selenium [Berger et al, unpublished data] Acute liver failure/cirrhosis Lipoperoxides [g] Zinc [h, i]

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Section: Route Of Deliverymentioning

confidence: 99%

Section: Route Of Deliverymentioning

confidence: 99%

Key Vitamins and Trace Elements in the Critically Ill

Berger

Chioléro²

2003

Nutrition and Critical Care

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“…Low plasma levels of zinc (Zn) and copper (Cu) are inadequately compensated for during hospitalization [1], and enteral supplements are unsuccessful in correcting the status [2]. Additionally, there are currently no clear recommendations regarding trace element requirements in children.…”

mentioning

confidence: 99%

Substitution of exudative trace element losses in burned children

et al. 2010

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“…Randomized controlled trials are few in adults, and there are only open studies in children: oral Cu and Zn supplementation was attempted in the 1970 [25], but failed to correct the status due to mucosal competition for absorption between Cu and Zn. This has led to the intravenous administration of TE supplements, as it has repeatedly observed in burned children on parenteral nutrition, that the doses of Cu required to maintain adequate plasma levels were much higher than in non-burned patients [26,27].…”

Section: Human Trialsmentioning

confidence: 97%

“…Of note: the oral route does not enable delivering such doses of Cu and Zn: the oral delivery of large doses of Zn causes or worsens hypocupremia [25,34].…”

Section: Article In Pressmentioning

confidence: 99%