Zinc and copper levels in serum, urine, and hair of humans in relation to blood pressure

Vivoli, Gianfranco; Borella, Paola; Bergomi, Margherita; Fantuzzi, Guglielmina

doi:10.1016/0048-9697(87)90077-5

Cited by 29 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study carried out on hair samples obtained from nearly 400 HTN patients revealed lower levels of Cu and Zn in the hair compared to a healthy control [ 56 ]. These results do not corroborate the data obtained by us and Vivoli et al, who found no difference between patients with or without hypertension [ 57 ]. Another risk factor for CAD, diabetes, was previously found to be not correlated with Cu values in hair compared to healthy individuals [ 58 ], which is consistent with our results.…”

Section: Discussioncontrasting

confidence: 99%

Investigation on the Association of Copper and Copper-to-Zinc-Ratio in Hair with Acute Coronary Syndrome Occurrence and Its Risk Factors

et al. 2022

View full text Add to dashboard Cite

The prevalence of coronary artery disease (CAD) increases every year; however, the impact of microelements on its underlying cause—atherosclerosis—is still unclear. Copper plays numerous regulatory roles in cardiovascular health and was suggested to influence the classic risk factors for CAD. The copper-to-zinc-ratio (Cu/Zn-ratio) reflects systemic oxidative stress–one of the factors in the complex pathogenesis of atherosclerosis. Hair incorporates metal ions during its growth; thus, it reflects the metal exposure that occurred over the last 4–8 weeks. The aim of the presented study was to verify the association between Cu and Cu/Zn-ratio content and the occurrence of acute coronary syndrome (ACS) in the hair of 133 patients who underwent coronary angiography due to suspected ACS. Additionally, association between Cu and Cu/Zn-ratio and selected risk factors for CAD was analyzed. Neither Cu nor Cu/Zn-ratio levels were associated with the occurrence of ACS, regardless of its type (UA/NSTEMI/STEMI). We did not find a significant association between Cu content in hair and risk factors for CAD. The Cu/Zn-ratio in hair was significantly correlated only with body mass index. The relationship of Cu content and Cu/Zn-ratio in hair with CAD, its risk factors and ACS appears to be complex and requires further well-designed research.

show abstract

Section: Discussioncontrasting

confidence: 99%

Investigation on the Association of Copper and Copper-to-Zinc-Ratio in Hair with Acute Coronary Syndrome Occurrence and Its Risk Factors

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Increased urinary copper in the HT patients correlated positively with SP and DP, but an inverse relationship between serum Cu and DP suggested that Cu bioavailability involved in blood pressure regulation might be reduced as suggested by many workers [27,65].…”

Section: Discussionmentioning

confidence: 79%

Mineral Factors Controlling Essential Hypertension—a Study in the Chandigarh, India Population

Taneja

Mandal

2007

Biol Trace Elem Res

View full text Add to dashboard Cite

Essential hypertension (EH) is a major public health problem world over and in India. Recent data on EH in the population of Chandigarh (Union Territory and capital of Punjab and Haryana States of India) revealed that the prevalence of EH has become double in the last 30 years in the residents of Chandigarh (26.9 to 45.80% in the year 1968 and 2002). Zinc (Zn), copper (Cu), magnesium (Mg), and manganese (Mn) in the serum are considered important in maintaining the human hypertension. The high Zn intake was considered to increase the blood pressure (BP) and to affect the other mineral status in the body. Recent survey on the trace metal status of different vegetables in the State of Punjab around Chandigarh (India) revealed that Zn level is significantly higher (40 mg/kg or more in above ground vegetables and 120 mg/kg or above in underground vegetables) in underground water-irrigated vegetables, but the levels of Cu and Mg are within prescribed limit. The present study was conducted on Chandigarh population to evaluate the levels of Zn, Cu, Mg, and Mn in the blood and urine of normotensive (NT) control and hypertensive (HT) subjects matched with number, age and sex. Atomic absorption spectrophotometer studies reevaluated that the levels of serum Zn, Mg, and Mn were significantly higher (p < 0.001), but the level of Cu was low in the HT subjects (BP = 160/93) compared to NT control (BP = 140/83). Higher levels of urinary Zn, Cu, Mg, and Mn were observed in the HT subject vs NT control (p < 0.001). Positive correlations were evaluated between the levels of serum Zn, Mg, and Mn vs systolic and diastolic pressures (DP and SP), respectively (r = 0.928, 0.863, 0.876, 0.808, 0.404, 0.326, p < 0.01), but negative and positive nonsignificant correlations between the serum Cu with SP and DP were recorded (r = -0.032, r = 0.024). Positive correlations were also evaluated between urinary levels of Zn, Cu, Mg, and Mn vs SP and DP (r = 0.718, 0.657, 0.750, 0.681, 0.630, 0.578, 0.516, 0.461, p < 0.01). Prevalence of essential hypertension may be due to higher Zn level in the food chain that makes the individuals vulnerable to other diseases over the time related to essential hypertension.

show abstract

“…In 1972 Hambidge et al [16] demonstrated that eight out of ten children aged 4-17 years old, with hair zinc values below 70 gg/g, exhibited growth retardation, anorexia and hypogeusia. Recently, Vivoli et al [40] described the same symptoms in 10-to 11-year-old children. Bergmann et al [5] speculated that dilution of zinc during rapid growth may lead to low hair zinc levels, providing there is still sufficient zinc for growth.…”

Section: Discussionmentioning

confidence: 84%

“…Both girls and boys showed a similar increase, but we found higher values in girls from Westphalia than in boys. A sex difference is normally reported to occur in prepubertal and pubertal children [3,9,11,20,40]. Walravens et al [41,42] only observed in healthy male infants or in small preschool boys a significant growth increase after zinc supplementation, demonstrating that prepub- a Standard error of mean ertal boys may be especially prone to zinc deficiency.…”

Section: Discussionmentioning

confidence: 94%

Hair zinc of young children from rural and urban areas in North Rhine-Westphalia, Federal Republic of Germany

et al. 1988

View full text Add to dashboard Cite

Hair zinc levels were estimated by atomic absorption spectrophotometry in 474 children, aged 3-7 years, from 11 kindergartens in a highly industrialized and polluted area (Duisburg) and 8 kindergartens in a rural area of North Rhine-Westphalia. The mean hair zinc level amounted to 118 micrograms/g, increasing between the 4th and 7th year of life. At all ages the values from the urban toddlers were lower than from rural toddlers, and in both regions they were higher in winter than in summer. Children with frequent upper respiratory tract infections (greater than 6 infections/year) showed significantly lower zinc hair values, independent of their age. Low hair zinc values (below 70 micrograms/g) were frequently found, raising the question as to whether this is a normal, age-related phenomenon, or whether it indicates a suboptimal zinc status of young children from North Rhine-Westphalia.

show abstract

Zinc and copper levels in serum, urine, and hair of humans in relation to blood pressure

Cited by 29 publications

References 25 publications

Investigation on the Association of Copper and Copper-to-Zinc-Ratio in Hair with Acute Coronary Syndrome Occurrence and Its Risk Factors

Investigation on the Association of Copper and Copper-to-Zinc-Ratio in Hair with Acute Coronary Syndrome Occurrence and Its Risk Factors

Mineral Factors Controlling Essential Hypertension—a Study in the Chandigarh, India Population

Hair zinc of young children from rural and urban areas in North Rhine-Westphalia, Federal Republic of Germany

Contact Info

Product

Resources

About