Zinc and copper in different types of heart failure

Ghaemian, Ali; Salehifar, Ebrahim; Shokrzadeh, Mohammad

doi:10.5414/tep27057

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“…Studies carried out in recent years show the significance of this trace element for the development of a number of cardiovascular diseases. Changes have been observed in the serum level in ischemic heart disease [5,6], heart failure [7,8], and cardiomyopathies [9,10]. According to some authors, deviations in copper homeostasis are an Page -02…”

Section: Introductionmentioning

confidence: 99%

Assessment of Copper Status in Patients with Paroxysmal Atrial Fibrillation

2014

J Cardiobiol

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Background: Recent research has demonstrated disturbances of copper balance in the development of cardiovascular diseases.Copper status in patients with atrial fibrillation is still unknown. Serum or plasma copper and ceruloplasmin activity are widely used laboratory indicators of copper status.Purpose: То evaluate copper status in the early hours of paroxysmal atrial fibrillation and monitor its changes after sinus rhythm restoration.Methods: Serum copper levels and plasma oxidase activity of ceruloplasmin were measured in 33 patients with paroxysmal atrial fibrillation (17 males, 16 females, mean age 60.03±1.93). Indicators were measured upon hospital admission, on the 24 th hour and on the 28 th day after sinus rhythm restoration. Thirty-three control subjects were also enrolled in the study (17 males, 16 females, mean age 59.27±1.72) and their indicators were measured only once. Copper levels and ceruloplasmin activity were quantified by atomic absorption spectrometry and colorimetric enzymatic assay respectively.Results: Mean duration of atrial fibrillation episodes up to hospitalization was 8.64±1.03 hours (from 2 hours up to 24 hours). Upon admission, patients' copper levels and ceruloplasmin activity were decreased compared to controls (16.77±0.59 vs. 18.30±0.45 µmol/L, p<0.05; 0.03±0.01 vs. 0.07±0.01 A 530 /mg protein, p<0.001 respectively). 24 hours after rhythm conversion, copper was not substantially different (17.11±0.71 vs. 18.30±0.45 µmol/L, p>0.05), whereas ceruloplasmin activity was diminished (0.05±0.01 vs. 0.07±0.01 A 530 /mg protein, p<0.001). On 28th day we established significant difference in neither of the indicators (17.61±0.48 vs. 18.30±0.45 µmol/L, p>0.05; 0.06±0.01 vs. 0.07±0.01 A 530 /mg protein, p>0.05). Conclusion:Our results provide evidence for disturbances of copper homeostasis in patients with paroxysmal atrial fibrillation. Decreased copper levels and ceruloplasmin activity during the first hours of arrhythmia and their subsequent elevation following sinus rhythm restoration give us grounds to assume that these changes are closely related to the disease pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Assessment of Copper Status in Patients with Paroxysmal Atrial Fibrillation

2014

J Cardiobiol

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Zinc and copper in different types of heart failure

Cited by 1 publication

References 0 publications

Assessment of Copper Status in Patients with Paroxysmal Atrial Fibrillation

Assessment of Copper Status in Patients with Paroxysmal Atrial Fibrillation

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