Zinc and cardiovascular disease

Little, Peter J.; Bhattacharya, Runa; Moreyra, Abel E.; Korichneva, Irina

doi:10.1016/j.nut.2010.03.007

Cited by 190 publications

(144 citation statements)

References 72 publications

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“…A number of studies have examined the association of zinc with coronary diseases, cardiomyopathies and arrhythmias, and links between etiopathogenesis of CVD have been suggested [89][90][91]. Aberrant Zn 2+ -homeostasis is associated with cardiomyopathy including chronic heart failure and myocardial damage [11,89], as well as primary arterial hypertension [92,93].…”

Section: Cellular Effects Of Altered Plasma Zinc Speciation and Cardimentioning

confidence: 99%

“…Aberrant Zn 2+ -homeostasis is associated with cardiomyopathy including chronic heart failure and myocardial damage [11,89], as well as primary arterial hypertension [92,93]. Many intracellular enzymes and other proteins involved in regulating cardiac function are Zn 2+ -dependent [89]; furthermore, zinc homeostasis and intracellular redox balance are intimately linked [6,94].…”

Section: Cellular Effects Of Altered Plasma Zinc Speciation and Cardimentioning

confidence: 99%

“…There is cross-talk between the fluxes of Ca 2+ and Zn 2+ [106]; hence, it is thought that zinc dyshomeostasis will impact on Ca 2+ trafficking in cardiomyocytes (as recently reviewed in [107]). Various studies suggest that defective Zn 2+ handling contributes to cardiomyopathies including altered contractility and heart failure [89,[108][109][110]. Indeed, it has been hypothesised that increased cytosolic Zn 2+ can influence cardiac excitationcontraction coupling through regulation of the ryanodine receptor in cardiomyocytes [111,112].…”

Section: +mentioning

confidence: 99%

“…Zinc also impacts on various other signalling networks, including those involving protein kinase C (PKC), which plays a central role in many signalling pathways in endothelial and vascular smooth muscle cells [123]. Thrombin, angiotensin and endothelin all trigger the activation of PKC, via signalling cascades involving Gprotein-coupled receptors and phospholipase C. The latter hydrolyses phospholipids, and the resulting diacylglycerols activate PKC [89,124]. PKC contains a redox-sensitive zincbinding site, and it is thought that through this site, the cellular redox state regulates the activity of PKC [89].…”

Section: Zinc Dyshomeostasis In Atherosclerosismentioning

confidence: 99%

“…Thrombin, angiotensin and endothelin all trigger the activation of PKC, via signalling cascades involving Gprotein-coupled receptors and phospholipase C. The latter hydrolyses phospholipids, and the resulting diacylglycerols activate PKC [89,124]. PKC contains a redox-sensitive zincbinding site, and it is thought that through this site, the cellular redox state regulates the activity of PKC [89]. The link between zinc and cellular redox state is well established [6].…”

Section: Zinc Dyshomeostasis In Atherosclerosismentioning

confidence: 99%

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Fatty Acid-Mediated Inhibition of Metal Binding to the Multi-Metal Site on Serum Albumin: Implications for Cardiovascular Disease

Blindauer

Khazaipoul²,

Yu³

et al. 2016

CTMC

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(2016) Fatty acid-mediated inhibition of metal binding to the multi-metal site on serum albumin : implications for cardiovascular disease. Current Trends in Medicinal Chemistry, 16. Permanent WRAP URL:http://wrap.warwick.ac.uk/78963 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way.Publisher's statement: © Bentham Science Publishers. http://dx.doi.org/10.2174/1568026616666160216155927 A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP URL' above for details on accessing the published version and note that access may require a subscription. Abstract: Human serum albumin (HSA) is the major protein in blood plasma and is responsible for circulatory transport of a range of small molecules including fatty acids, metal ions and drugs. We previously identified the major plasma Zn 2+ transport site on HSA and revealed that fatty-acid binding (at a distinct site called the FA2 site) and Zn 2+ binding are interdependent via an allosteric mechanism. Since binding affinities of long-chain fatty acids exceed those of plasma Zn 2+ , this means that under certain circumstances the binding of fatty acid molecules to HSA is likely to diminish HSA Zn 2+ -binding, and hence affects the control of circulatory and cellular Zn 2+ dynamics. This relationship between circulatory fatty acid and Zn 2+ dynamics is likely to have important physiological and pathological implications, especially since it has been recognised that Zn 2+ acts as a signalling agent in many cell types. Fatty acid levels in the blood are dynamic, but most importantly, chronic elevation of plasma fatty acid levels is associated with some metabolic disorders and disease states -including myocardial infarction and other cardiovascular diseases. In this article, we briefly review the metalbinding properties of albumin and highlight the importance of their interplay with fatty acid binding. We also consider the impact of this dynamic link upon levels and speciation of plasma Zn 2+ , its effect upon cellular Zn 2+ homeostasis and its relevance to cardiovascular and circulatory processes in health and disease.

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Section: Cellular Effects Of Altered Plasma Zinc Speciation and Cardimentioning

confidence: 99%

Section: Cellular Effects Of Altered Plasma Zinc Speciation and Cardimentioning

confidence: 99%

Section: +mentioning

confidence: 99%

Section: Zinc Dyshomeostasis In Atherosclerosismentioning

confidence: 99%

Section: Zinc Dyshomeostasis In Atherosclerosismentioning

confidence: 99%

See 3 more Smart Citations

Fatty Acid-Mediated Inhibition of Metal Binding to the Multi-Metal Site on Serum Albumin: Implications for Cardiovascular Disease

Blindauer

Khazaipoul²,

Yu³

et al. 2016

CTMC

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Effects of Metal Ions on Platelet Function

2018

Nutraceuticals and Human Blood Platelet Function

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Influence of Sr and Mn Elements on the Microstructural Characteristics, Mechanical, and Anticorrosion Properties of Zn‐Based Biodegradable Materials

Wang,

Yu,

Jung

2023

Adv Eng Mater

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This study specifically focused on investigating the effects of Mn and Sr additions on the microstructure, mechanical properties, and anti‐corrosion behavior of as‐extruded Zn‐Mn‐Sr alloys, with the ultimate goal of developing biodegradable implants. The microstructural observations revealed that the incorporation of Mn and Sr elements played a crucial role in refining the hcp (Zn) grains within the alloys. Moreover, intermetallic phase SrZn13 were observed to precipitate along with the eutectic microstructure. These microstructural changes contributed to the overall mechanical properties of the alloys. Mechanical testing demonstrated that increasing the Sr content in the alloys resulted in improved strength. Thus, the addition of Sr showed the potential to enhance the mechanical properties of Zn‐Mn alloys, but it also resulted in a trade‐off with ductility. Notable alloys, BZA920, exhibited the highest values of yield strength (YS) at 219.8 ± 5.2 MPa and ultimate tensile strength (UTS) at 240.6 ± 4.3 MPa；alloys of BZA315, BZA615, and BZA915 exhibited excellent ductility of over 40%. These enhanced mechanical properties were attributed to the grain refinement and lattice distortion induced by the presence of Mn and Sr. The electrochemical and immersion tests conducted in simulated body fluid (SBF) solution demonstrated the alloys’ favorable corrosion resistance. The corrosion rates ranged from 0.05 to 0.15 mm/year, indicating their potential suitability as implant materials. Overall, this study highlighted the exceptional mechanical properties, favorable corrosion resistance, and excellent biocompatibility of the investigated Zn‐Mn‐Sr alloys, which positions Zn‐Mn‐Sr alloys as highly promising candidates for biodegradable implants.This article is protected by copyright. All rights reserved.

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Zinc and cardiovascular disease

Cited by 190 publications

References 72 publications

Fatty Acid-Mediated Inhibition of Metal Binding to the Multi-Metal Site on Serum Albumin: Implications for Cardiovascular Disease

Fatty Acid-Mediated Inhibition of Metal Binding to the Multi-Metal Site on Serum Albumin: Implications for Cardiovascular Disease

Effects of Metal Ions on Platelet Function

Influence of Sr and Mn Elements on the Microstructural Characteristics, Mechanical, and Anticorrosion Properties of Zn‐Based Biodegradable Materials

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