Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties

Qu, Xinhua; Yang, Hongtao; Jia, Bo; Wang, Minqi; Yue, Bing; Zheng, Yufeng; Dai, Kerong

doi:10.1016/j.bioactmat.2021.05.023

Cited by 56 publications

(72 citation statements)

References 60 publications

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“…Evaluation of gross bone pathology and radiology: The cortical bone destruction of rats was examined with X-ray after 3 weeks. The radiographic scores were calculated as described in previous studies (N = 5) [ 35 , 36 ]. Five rats per group were sacrificed 3 weeks after surgery, and the femurs were dissected to evaluate the gross bone pathology according to the aforementioned criteria.…”

Section: Methodsmentioning

confidence: 99%

Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection

Nie

Huo

et al. 2022

Bioactive Materials

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Section: Methodsmentioning

confidence: 99%

Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection

Nie

Huo

et al. 2022

Bioactive Materials

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“…For determine the cytotoxicity of felodipine at its MIC level, the viability of HepG2 (ATCC HB-8065), human keratinocytes (HaCaT) and rat bone marrow mesenchymal stem cells (rBMSC) were examined as previously described [ [32] , [33] , [34] ]. Briefly, 100 μL of HepG2, HaCaT and rBMSC cells were inoculated into a 96-well plate at a density of 1.0 × 10 4 /well and incubated at 37 °C 5% CO 2 for 24 h to allow cells to adhere to the plate.…”

Section: Methodsmentioning

confidence: 99%

Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus, persisters and biofilms

Zhang

Jiao

et al. 2022

Bioactive Materials

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“…Significant historical developments have previously been described ( 36 , 64 , 78 , 79 ). Currently, the most popular rat models are of long bone osteomyelitis and most often utilize the tibia ( 17 , 22 , 80 – 83 ) or femur ( 84 – 90 ). Long bone models rely on mechanical trauma, placement of foreign bodies, or creation of fractures, all typically with concurrent sealing of the defect area with bone wax to contain bacterial inoculums and prevent concomitant soft tissue infection.…”

Section: Small Animal Modelsmentioning

confidence: 99%

Role of Animal Models to Advance Research of Bacterial Osteomyelitis

Billings

Anderson

2022

Front. Vet. Sci.

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Osteomyelitis is an inflammatory bone disease typically caused by infectious microorganisms, often bacteria, which causes progressive bone destruction and loss. The most common bacteria associated with chronic osteomyelitis is Staphylococcus aureus. The incidence of osteomyelitis in the United States is estimated to be upwards of 50,000 cases annually and places a significant burden upon the healthcare system. There are three general categories of osteomyelitis: hematogenous; secondary to spread from a contiguous focus of infection, often from trauma or implanted medical devices and materials; and secondary to vascular disease, often a result of diabetic foot ulcers. Independent of the route of infection, osteomyelitis is often challenging to diagnose and treat, and the effect on the patient's quality of life is significant. Therapy for osteomyelitis varies based on category and clinical variables in each case. Therapeutic strategies are typically reliant upon protracted antimicrobial therapy and surgical interventions. Therapy is most successful when intensive and initiated early, although infection may recur months to years later. Also, treatment is accompanied by risks such as systemic toxicity, selection for antimicrobial drug resistance from prolonged antimicrobial use, and loss of form or function of the affected area due to radical surgical debridement or implant removal. The challenges of diagnosis and successful treatment, as well as the negative impacts on patient's quality of life, exemplify the need for improved strategies to combat bacterial osteomyelitis. There are many in vitro and in vivo investigations aimed toward better understanding of the pathophysiology of bacterial osteomyelitis, as well as improved diagnostic and therapeutic strategies. Here, we review the role of animal models utilized for the study of bacterial osteomyelitis and their critically important role in understanding and improving the management of bacterial osteomyelitis.

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Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties

Cited by 56 publications

References 60 publications

Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection

Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection

Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus, persisters and biofilms

Role of Animal Models to Advance Research of Bacterial Osteomyelitis

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