Zimmerman‐Laband syndrome and profound mental retardation

Bn, Chodirker; Chudley, AE; Ma, Toffler; Mh, Reed

doi:10.1002/ajmg.1320250317

Cited by 34 publications

(21 citation statements)

References 7 publications

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“…This condition is similar to one described by Anavi et al [1989], but also overlaps various syndromes characterized by gingival hypertrophy [Zimmermann, 1928;Lä-wen, 1929;Laband et al, 1964;Alavandar, 1965;Snyder, 1965;Witkop, 1971;Winter and Simpkiss, 1974;Chodirker et al, 1986;de Pina Neto et al, 1988;Kiss, 1990;Takagi et al, 1991;Pfeiffer et al, 1992;Chadwick et al, 1994;Lacombe et al, 1994;Pavone et al, 1996;Pavone et al, 1997]. Among these are autosomal recessive and dominant disorders.…”

Section: Introductionsupporting

confidence: 79%

“…Numerous syndromes are described characterized by gingival hypertrophy and mental retardation [Zimmermann, 1928;Lä wen, 1929;Laband et al, 1964;Snyder, 1965;Houston and Shotts, 1966;Winter and Simpkiss, 1974;Cross et al, 1967;de Pina Neto, 1986, 1988Chodirker et al, 1986;Anavi et al, 1989;Kiss , 1990;Takagi et al, 1991;Pfeiffer et al, 1992;Chadwick et al, 1994;Lacombe et al, 1994;Pavone et al, 1996Pavone et al, , 1997.…”

Section: Discussionmentioning

confidence: 99%

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Syndrome of gingival hypertrophy, hirsutism, mental retardation and brachymetacarpia in two sisters: Specific entity or variant of a described condition?

et al. 2000

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Two sisters born to consanguineous Lebanese parents had mental retardation and epilepsy, brachymetacarpalia, hirsutism, bulbous soft nose, thick floppy ears with abnormal configuration and gingival hypertrophy. One girl presented additionally with tetralogy of Fallot and the other with congenital hypothyroidism and bilateral ureteral stenosis. These manifestations resemble the syndrome of hypertrichosis-gingival fibromatosis-mental retardation and seizures of Anavi et al. [1989: Dev Med Child Neurol 31:538-542] but our two girls additionally have brachymetacarpia. The inheritance seems to be autosomal recessive. These two sisters may represent a hitherto undescribed syndrome. We discuss the findings in our patients in relation to the literature.

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Section: Introductionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Syndrome of gingival hypertrophy, hirsutism, mental retardation and brachymetacarpia in two sisters: Specific entity or variant of a described condition?

et al. 2000

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“…A total of 33 cases of this syndrome have been reported in the literature to date [1–5,7–20]. (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…The number of other occasional clinical findings observed in patients with Zimmermann–Laband syndrome (Table 3) demonstrates the morphological variability of this syndrome. Learning disability has been documented in 11 reports [8–18], in which it was mild in eight and profound in the other three. Our patient was also moderately retarded with an IQ level of 45–50.…”

Section: Discussionmentioning

confidence: 99%

Zimmermann–Laband syndrome with bilateral developmental cataract – a new association?

Shah

Gupta

Ghose

2004

Int J Paed Dentistry

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An unusual case of Zimmermann-Laband syndrome in a young male child with an unreported association of bilateral developmental cataract is presented. The pathognomonic triad of gingival fibromatosis, aplastic or hypoplastic distal phalanges with absent nails, and enlargement of soft tissues of the face were obvious, besides the known moderate learning disability and mild hearing loss. The case is discussed in the light of relevant literature. To the best of our knowledge, this is the first report of early developmental cataracts in association with the Zimmermann-Laband syndrome. Besides detection and timely recognition of the syndrome to allow adequate dental care, ophthalmic screening at periodic intervals is merited to improve the overall quality of life for these patients.

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“…Tonic-clonic seizures have been reported so far in just a single patient with ZLS, who did not manifest GH (Chodirker et al, 1986). Two patients with the GH of Cantu syndrome presented with GO but had additional features and no seizures .…”

Section: Discussionmentioning

confidence: 92%

Gingival overgrowth, congenital generalized hypertrichosis, mental retardation and epilepsy: case report and overview

Douzgou¹,

Mingarelli

Dallapiccola³

2009

Clinical Dysmorphology

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We report on a patient with congenital generalized hypertrichosis, mental retardation, tonic-clonic seizures with onset during the first year of life and gingival overgrowth, unrelated to antiepileptic treatment. This phenotype represents a unique combination of features, bridging the variable association of gingival overgrowth, generalized hypertrichosis, mental retardation or epilepsy. This may occur in combination with nail and/or digital anomalies, as in Zimmermann-Laband syndrome, and the broader phenotypes of the Anavi, Göhlich-Ratmann and Ramon syndromes. On the basis of the clinical overlap between our patient and these disorders inherited either as autosomal dominant or recessive traits and unknown molecular defects, a recurrence risk of one in four was considered appropriate.

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Zimmerman‐Laband syndrome and profound mental retardation

Abstract: A young man was diagnosed as having Zimmerman-Laband syndrome (ZLS) on the basis of gingival fibromatosis and absence of nails on thumbs and halluces in addition to other anomalies. He also had profound mental retardation.

Cited by 34 publications

References 7 publications

Syndrome of gingival hypertrophy, hirsutism, mental retardation and brachymetacarpia in two sisters: Specific entity or variant of a described condition?

Syndrome of gingival hypertrophy, hirsutism, mental retardation and brachymetacarpia in two sisters: Specific entity or variant of a described condition?

Zimmermann–Laband syndrome with bilateral developmental cataract – a new association?

Gingival overgrowth, congenital generalized hypertrichosis, mental retardation and epilepsy: case report and overview

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