Zika Virus Vaccine: The Current State of Affairs and Challenges Posed by Antibody-Dependent Enhancement Reaction

Cheong, Heng Choon; Cheok, Yi Ying; Chan, Yee Teng; Sulaiman, Sofiah; Looi, Chung Yeng; Al-Shanon, Ahmed F.; Hassan, Jamiyah; AbuBakar, Sazaly; Wong, Won Fen

doi:10.1089/vim.2022.0082

Cited by 4 publications

(1 citation statement)

References 130 publications

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“…Currently, ZIKV vaccine is not yet available for public use. However, several ZIKV vaccine candidates are in different stages of preclinical and clinical development [ 16 ]. Therefore, the best means of prevention is to avoid the transmission of ZIKV through measures such as mosquito bite prevention, safe sexual practices, and adhere to travel advisories in regions where the virus is prevalent.…”

Section: Introductionmentioning

confidence: 99%

Has Zika been forgotten? A qualitative exploration of knowledge gaps, perceived risk and preventive practices in pregnant women in Malaysia

Wong,

Alias,

Lee

et al. 2024

BMC Women's Health

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Background Although Zika virus infection is rarely reported now, continuous prevention is needed to achieve sustained eradication. This study aimed to explore the knowledge gaps, risk perception and preventive measures against Zika virus infection (ZIKV) in pregnant women in Malaysia. Methods We conducted in-depth virtual interviews with pregnant women between February and April 2022. The interviews were recorded and transcribed, and data were analyzed by content analysis. Results The majority of the participants demonstrated a commendable level of awareness regarding the signs and symptoms associated with ZIKV infection. They also exhibited a clear understanding of preventive measures, particularly emphasizing the importance of avoiding mosquito bites to minimize the risk of ZIKV transmission. However, a noteworthy gap in knowledge surfaced as a subset of participants remained uninformed about the potential for sexual transmission of ZIKV, which could lead to congenital ZIKV in pregnant women. Even among women who were cognizant of ZIKV and its potential negative health outcomes, associated with the infection, many of them did not perceive themselves to be at risk, mainly because ZIKV infection is infrequently discussed or heard of, leading to a sense of infections’ rarity. While the adoption of preventive measures such as mosquito bite prevention during pregnancy was a common practice, however, prevention of sexually transmitted infections (STIs) including mosquito-borne diseases such as Zika is low. A minority of women express concerns about the sensitivity surrounding discussions and prevention of STIs within the context of marriage. Most of the participants were supportive of the provision of awareness of ZIKV infection in women during pregnancy and the involvement of men, especially in initiatives aimed at preventing transmission through sexual contact. Conclusion This study uncovered gaps in both knowledge and practices pertaining ZIKV infection among pregnant women in the aftermath of the ZIKV pandemic. The insights gleaned from our research are valuable for shaping future interventions geared towards preventing the resurgence or facilitating the sustainable eradication of ZIKV.

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Section: Introductionmentioning

confidence: 99%

Has Zika been forgotten? A qualitative exploration of knowledge gaps, perceived risk and preventive practices in pregnant women in Malaysia

Wong,

Alias,

Lee

et al. 2024

BMC Women's Health

Self Cite

View full text Add to dashboard Cite

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Current state of, prospects for, and obstacles to mRNA vaccine development

Aljabali

Bashatwah

Obeid

et al. 2023

Drug Discovery Today

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Immune Recognition versus Immune Evasion Systems in Zika Virus Infection

et al. 2023

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The reemergence of the Zika virus (ZIKV) infection in recent years has posed a serious threat to global health. Despite being asymptomatic or mildly symptomatic in a majority of infected individuals, ZIKV infection can result in severe manifestations including neurological complications in adults and congenital abnormalities in newborns. In a human host, ZIKV is primarily recognized by RIG-like receptors and Toll-like receptors that elicit anti-viral immunity through the secretion of type I interferon (IFN) to limit viral survival, replication, and pathogenesis. Intriguingly, ZIKV evades its host immune system through various immune evasion strategies, including suppressing the innate immune receptors and signaling pathways, mutation of viral structural and non-structural proteins, RNA modulation, or alteration of cellular pathways. Here, we present an overview of ZIKV recognition by the host immune system and the evasion strategies employed by ZIKV. Characterization of the host–viral interaction and viral disease mechanism provide a platform for the rational design of novel prophylactic and therapeutic strategies against ZIKV infection.

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Zika Virus Vaccine: The Current State of Affairs and Challenges Posed by Antibody-Dependent Enhancement Reaction

Cited by 4 publications

References 130 publications

Has Zika been forgotten? A qualitative exploration of knowledge gaps, perceived risk and preventive practices in pregnant women in Malaysia

Has Zika been forgotten? A qualitative exploration of knowledge gaps, perceived risk and preventive practices in pregnant women in Malaysia

Current state of, prospects for, and obstacles to mRNA vaccine development

Immune Recognition versus Immune Evasion Systems in Zika Virus Infection

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