Zika Virus Seroprevalence, French Polynesia, 2014–2015

Aubry, Maïté; Teissier, Anita; Huart, Michael; Merceron, Sébastien; Vanhomwegen, Jessica; Roche, Claudine; Vial, Anne-Laure; Teururai, Sylvianne; Sicard, Sébastien; Paulous, Sylvie; Desprès, Philippe; Manuguerra, Jean-Claude; Mallet, Henri‐Pierre; Musso, Didier; Deparis, Xavier; Cao-Lormeau, Van-Mai

doi:10.3201/eid2304.161549

Cited by 161 publications

(163 citation statements)

References 14 publications

Supporting

Mentioning

140

Contrasting

Unclassified

Order By: Relevance

“…Given the small numbers, a statistically significant link between congenital WNV infection and microcephaly was not established. It is worth noting that the association of WNV infection with congenital malformation in this study resembles that observed from a larger retrospective analysis of ZIKV-induced congenital diseases during the 2013 outbreak in French Polynesia where there were 95 cases of microcephaly in 10,000 pregnancies (rate of 0.95%) and the seroprevalence was 50% ( 46, 47 ). Thus, it is possible that the rate of flavivirus-induced congenital malformations could be similar for WNV and ZIKV, but the overall impact of congenital ZIKV infection is much greater because of the comparatively low seroprevalence rate of 1–5% for WNV ( 48, 49 ).…”

Section: Discussionsupporting

confidence: 80%

Zika virus–related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice

et al. 2018

View full text Add to dashboard Cite

Although Zika virus (ZIKV) infection in pregnant women can cause placental damage, intrauterine growth restriction, microcephaly, and fetal demise, these disease manifestations only became apparent in the context of a large epidemic in the Americas. We hypothesized that ZIKV is not unique among arboviruses in its ability to cause congenital infection. To evaluate this, we tested the capacity of four emerging arboviruses (West Nile virus, WNV; Powassan virus, POWV; chikungunya virus, CHIKV; and Mayaro virus, MAYV) from related (flavivirus) and unrelated (alphavirus) genera to infect the placenta and fetus in immunocompetent, wild-type mice. Whereas all four viruses caused placental infection, only infection with the neurotropic flaviviruses (WNV and POWV) resulted in fetal demise. WNV and POWV also replicated efficiently in second-trimester human maternal (decidua) and fetal (chorionic villi and fetal membrane) explants whereas CHIKV and MAYV replicated less efficiently. In mice, RNA in situ hybridization and histopathological analysis revealed that WNV infected the placenta and fetal central nervous system, causing injury to the developing brain. In comparison, CHIKV and MAYV did not cause substantive placental or fetal damage despite evidence of vertical transmission. Based on the susceptibility of human maternal and fetal tissue explants and pathogenesis experiments in immunocompetent mice, other emerging neurotropic flaviviruses may share with ZIKV the capacity for transplacental transmission, and subsequent infection and injury to the developing fetus.

show abstract

Section: Discussionsupporting

confidence: 80%

Zika virus–related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice

et al. 2018

View full text Add to dashboard Cite

show abstract

“…However, the demonstration of nonvector‐borne transmission through sexual contact and the transfusion of contaminated blood products has raised concerns over the safety of the blood supply in areas with epidemic and endemic ZIKV . When comparing ZIKV with other arboviruses (Table ), infection results in a high percentage of asymptomatic viremic carriers, similar to DENV and WNV but unlike chikungunya virus (CHIKV). Notably, ZIKV, like WNV, causes various neurologic symptoms.…”

Section: Comparison Of Properties and Characteristics For Prominent Ementioning

confidence: 99%

Inactivation of Zika virus in platelet components using amotosalen and ultraviolet A illumination

et al. 2017

Self Cite

View full text Add to dashboard Cite

BACKGROUND Concerned over the risk of Zika virus (ZIKV) transfusion transmission, public health agencies recommended the implementation of mitigation strategies for its prevention. Those strategies included the use of pathogen inactivation for the treatment of plasma and platelets. The efficacy of amotosalen/ultraviolet A to inactivate ZIKV in plasma had been previously demonstrated, and the efficacy of inactivation in platelets with the same technology was assumed. These studies quantify ZIKV inactivation in platelet components using amotosalen/ultraviolet A. STUDY DESIGN AND METHODS Platelet components were spiked with ZIKV, and ZIKV infectious titers and RNA loads were measured by cell culture‐based assays and real‐time polymerase chain reaction in spiked platelet components before and after photochemical treatment using amotosalen/ultraviolet A. RESULTS The mean ZIKV infectivity titers and RNA loads in platelet components before inactivation were either 4.9 log10 plaque forming units per milliliter, or 4.4 log10 50% tissue culture infective dose per milliliter and 7.5 log10 genome equivalents per milliliter, respectively. No infectivity was detected immediately after amotosalen/ultraviolet A treatment. No replicative virus remained after treatment, as demonstrated by multiple passages on Vero cell cultures; and ZIKV RNA was not detected from the first passage after inactivation. Additional experiments in this study demonstrated efficient inactivation to the limit of detection in platelets manufactured in 65% platelet additive solution, 35% plasma, or 100% plasma. CONCLUSION As previously demonstrated for plasma, robust levels of ZIKV inactivation were achieved in platelet components. With inactivation of higher levels of ZIKV than those reported in asymptomatic, RNA‐reactive blood donors, the pathogen‐inactivation system using amotosalen/ultraviolet A offers the potential to mitigate the risk of ZIKV transmission by plasma and platelet transfusion.

show abstract

“…La seroprevalencia estimada al final de la epidemia era del 49%, pero fue del 66% en los escolares de Tahití. Numerosos casos eran asintomáticos [66] . En esta ocasión, la incidencia del síndrome de Guillain-Barré se multiplicó por 17 con respecto a su incidencia habitual.…”

Section: Infección Por El Virus De Zikaunclassified

Conducta práctica ante un niño febril al regresar de un viaje

Minodier

Imbert

2019

EMC - Pediatría

View full text Add to dashboard Cite

Las enfermedades más frecuentes al regresar de un viaje al extranjero son las infecciones gastrointestinales, las enfermedades febriles y los problemas dermatológicos. La evaluación de un niño febril al regreso de un viaje es clínica: verificación de los antecedentes y las vacunaciones, búsqueda de otros casos en contacto, signos funcionales y físicos, y características del viaje. Unas pruebas complementarias de rutina completan a menudo la evaluación para una orientación sindrómica. Si bien las causas de fiebre son, sobre todo, cosmopolitas, la gravedad de la enfermedad exótica obliga a buscarlas prioritariamente. El paludismo debe sospecharse ante una fiebre procedente de África subsahariana. El diagnóstico se basa en la asociación de un frotis sanguíneo y una prueba sensible (gota gruesa, reacción en cadena de la polimerasa [PCR]) o una prueba de diagnóstico rápido (para Plasmodium falciparum). Los criterios clínico-biológicos de gravedad son esenciales para orientar y tratar al paciente. En caso de acceso no complicado por P. falciparum, el tratamiento se basa en un tratamiento combinado a base de artemisinina (ACT), arteméter-lumefantrina o artenimol-piperaquina. Los accesos graves se tratan con artesunato intravenoso, seguido de ACT oral. Dengue, chikungunya e infección por virus Zika tienen características clínicas comunes (fiebre-erupción-artralgias, tratamiento sintomático). En caso de dengue, conviene controlar la aparición de signos de alerta, que podrían hacer temer una evolución negativa. El chikungunya es grave en caso de transmisión en el parto, con un riesgo de encefalitis neonatal. En el niño, el Zika es asintomático o poco sintomático. Pero, en caso de infección durante el embarazo, el riesgo es el de una embriofetopatía. El diagnóstico de estas arbovirosis se basa en la PCR en la fase aguda y en la serología secundariamente. La sintomatología de la fiebre tifoidea es poco específica, lo cual justifica la práctica de hemocultivos sistemáticos ante una fiebre tras un viaje. Su tratamiento se basa en las cefalosporinas de tercera generación o el ciprofloxacino, pero las resistencias aumentan. En suma, la diversidad de las etiologías de una fiebre al regreso de un viaje y la potencial gravedad de las infecciones importadas imponen una reflexión sobre el proceso de tratamiento de estos pacientes, en especial en lo referente al riesgo de fiebre hemorrágica. © 2019 Elsevier Masson SAS. Todos los derechos reservados.Conducta práctica ante un niño febril al regresar de un viaje 2 EMC -Pediatría Conducta práctica ante un niño febril al regresar de un viaje E -4-320-A-20

show abstract

Zika Virus Seroprevalence, French Polynesia, 2014–2015

Cited by 161 publications

References 14 publications

Zika virus–related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice

Zika virus–related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice

Inactivation of Zika virus in platelet components using amotosalen and ultraviolet A illumination

Conducta práctica ante un niño febril al regresar de un viaje

Contact Info

Product

Resources

About