Zika Virus Infection Associated With Congenital Birth Defects in a HIV-infected Pregnant Woman

João, Esaú; Gouvêa, Maria Isabel Fragoso da Silveira; Teixeira, Maria de Lourdes Benamor; Mendes‐Silva, Wallace; Esteves, Juliana Silva; Santos, Edwiges Motta; Ledesma, Leandro Augusto; Gomes, Ana Paula Neutzling; Cruz, Maria Letícia Santos

doi:10.1097/inf.0000000000001482

Cited by 15 publications

(16 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have revealed a significant increase in the number of HIV-ZIKV co-infected individuals reported in endemic areas in America [ 20 – 23 ] and Africa [ 24 ]. Additionally, the National Institute of Health (NIH) initiated an international, multisite clinical study, “Prospective Cohort Study of HIV and ZIKV in Infants and Pregnancy” (HIV ZIP; ClinicalTrials.gov, # NCT03263195) to register 2,000 pregnant women for the purpose of investigating ZIKV/HIV co-infection in the United States, Brazil, and Puerto Rico.…”

Section: Discussionmentioning

confidence: 99%

SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model

et al. 2018

View full text Add to dashboard Cite

Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the disease pathogenesis of co-infection is urgently needed. This warrants the development of an animal model for HIV-ZIKV co-infection. In this study, we used adult non-pregnant macaques that were chronically infected with simian immunodeficiency virus/chimeric simian human immunodeficiency virus (SIV/SHIV) and then inoculated with ZIKV. Plasma viral loads of both SIV/SHIV and ZIKV co-infected animals revealed no significant changes as compared to animals that were infected with ZIKV alone or as compared to SIV/SHIV infected animals prior to ZIKV inoculation. ZIKV tissue clearance of co-infected animals was similar to animals that were infected with ZIKV alone. Furthermore, in co-infected macaques, there was no statistically significant difference in plasma cytokines/chemokines levels as compared to prior to ZIKV inoculation. Collectively, these findings suggest that co-infection may not alter disease pathogenesis, thus warranting larger HIV-ZIKV epidemiological studies in order to validate these findings.

show abstract

Section: Discussionmentioning

confidence: 99%

SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The problem in the HIV pregnant woman is also already reported [3]. João, et al mentioned that the concurrence "led to multiple fetal malformations and fetal demise [3]". Nevertheless, due to the lack of accumulated data, it is needed to have a long -term monitoring on this problem.…”

Section: Concurrent Hiv and Zika Virus Infection A Problem To Be Addmentioning

confidence: 90%

“…There is no significant important clinical observation on the concurrence [2]. The problem in the HIV pregnant woman is also already reported [3]. João, et al mentioned that the concurrence "led to multiple fetal malformations and fetal demise [3]".…”

Section: Concurrent Hiv and Zika Virus Infection A Problem To Be Addmentioning

confidence: 94%

See 1 more Smart Citation

Concurrent HIV and Zika Virus Infection, A Problem to be Address in HIV Medicine

Joob¹,

Wiwanitkit²

2017

Int J Virol AIDS

View full text Add to dashboard Cite

“…More research is needed. Until now, there are only few case reports in the literature, but these have occurred mainly in patients under antiretroviral therapy (ARV), then with good levels of CD4 [43,44,[46][47][48][49][50][51][52].…”

Section: Cocirculation and Coinfection Of Zikv With Nonarboviral Pathmentioning

confidence: 99%

Cocirculation and Coinfection Associated to Zika Virus in the Americas

Sánchez‐Duque¹,

Rodríguez‐Morales²,

Trujillo³

et al. 2018

Current Topics in Zika

View full text Add to dashboard Cite

Zika virus, a flavivirus, has arrived to Latin America in 2013. It became evident causing epidemics since 2015, first in Brazil and later in other countries in the region, such as Colombia, with a higher peak in 2016. The World Health Organization (WHO), based on cumulated evidence on its association with Guillain-Barre syndrome (GBS) and microcephaly and other birth defects (also the congenital Zika syndrome, CZS), declared for a period of almost a year, an international public health emergency. Epidemics in the region caused around 1 million cases with also additional complications beyond GBS and the CZS, which in patients with comorbidities lead to deaths. Among the events studied in the region, a number of cases with arboviral coinfections/codetection (dengue and chikungunya) were described and published beginning in Colombia and later in Brazil. In addition to that, cocirculation and still ongoing research on antibody-dependent enhancement (ADE) are challenges for physicians and public health authorities, given the implications for clinical manifestations and serological diagnosis in patients with previous exposition to other flaviviruses. We reviewed such aspects in this chapter.

show abstract

Zika Virus Infection Associated With Congenital Birth Defects in a HIV-infected Pregnant Woman

Abstract: We describe a case of Zika virus infection acquired during the first trimester in a HIV-infected pregnant woman that led to multiple fetal malformations and fetal demise in Rio de Janeiro, Brazil.

Cited by 15 publications

References 6 publications

SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model

SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model

Concurrent HIV and Zika Virus Infection, A Problem to be Address in HIV Medicine

Cocirculation and Coinfection Associated to Zika Virus in the Americas

Contact Info

Product

Resources

About