Zika Virus Infection Among Pregnant Women and Their Neonates in New York City, January 2016–June 2017

Conners, Erin E.; Lee, Ellen H.; Thompson, Corinne N.; McGibbon, Emily; Rakeman, Jennifer L.; Iwamoto, Martha; Cooper, Hannah; Vora, Neil M.; Limberger, Ronald J.; Fine, Anne D.; Liu, Dakai; Slavinski, Sally

doi:10.1097/aog.0000000000002737

Cited by 22 publications

(32 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, nearly 10% of the children born to mothers with confirmed or probable maternal ZIKV infection had neurologic and hearing adverse outcomes possibly associated with ZIKV exposure. This result supports published observations from a number of different countries such as United States [13], French Territories in Americas [11], or French Guiana [10], but it is much lower than the 42% observed in the Rio de Janeiro cohort [9]. Regarding audiological tests, 3.5% of children had abnormal results, which is a smaller proportion compared to the from a Brazilian cohort [21], but significant in relation to the results of a study in USA in which all ZIKV exposed infants of traveler pregnant women passed the test [22].…”

Section: Discussionsupporting

confidence: 93%

“…It is important to note that similar to other studies, this cohort faced important challenges with respect to ZIKV laboratory diagnosis, including the short period for the detection of the ZIKV RNA [6] and cross-reactivity in serological assays for ZIKV and DENV [25]. Similarly, this research faced the lack of a gold standard serological test to determine the exact onset of ZIKV infection and the ability to exclude other flavivirus infections such as DENV [9][10][11][12][13][14]. Our national referral laboratory ISCIII in Madrid lacked the infrastructure to be able to perform any PRNT for other flaviviruses.…”

Section: Discussionmentioning

confidence: 76%

“…In addition, evidence indicates that clinical presentation of congenital ZIKV syndrome (CZS) differs in severity and prognosis depending on the head circumference (HC) at birth and the central nervous system (CNS) damage [8]. Adverse clinical outcomes at birth or over the first year of life have been described in different cohorts, affecting between 10% and 45% of the offspring exposed to ZIKV in utero [9][10][11][12][13][14]. Most of these infants are expected to survive, and their estimated life span is expected to be comparable to other children with microcephaly, epilepsy, and intellectual disability [15].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain

et al. 2020

View full text Add to dashboard Cite

Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain

et al. 2020

View full text Add to dashboard Cite

show abstract

“…50 The New-York City cohort of ZIKV-exposed pregnant women reported proof of a congenital infection in 7% of confirmed or probable maternal ZIKV infections. 89 Available data do not seem to indicate an increased rate of maternal-fetal transmission with ongoing gestation, as for example in congenital toxoplasmosis. However, more studies are required to conclude on the evolution of transplacental infection according to the timing of maternal infection.…”

Section: Maternal-fetal Transmission Of Zikvmentioning

confidence: 99%

“…When positive placenta samples were removed from the analysis because of the theoretical risk of placental contamination by maternal viremia, the vertical transmission rate was estimated at 18% . The New‐York City cohort of ZIKV‐exposed pregnant women reported proof of a congenital infection in 7% of confirmed or probable maternal ZIKV infections . Available data do not seem to indicate an increased rate of maternal‐fetal transmission with ongoing gestation, as for example in congenital toxoplasmosis.…”

Section: Management Of Exposed Pregnancies and Recommandationsmentioning

confidence: 99%

Zika virus during pregnancy: From maternal exposure to congenital Zika virus syndrome

et al. 2019

View full text Add to dashboard Cite

What is already known about the topic? The Zika virus (ZIKV) emergence and its consequences during pregnancy led to an increasing number of data about the maternal and fetal consequences of ZIKV infections. What does this study add? This review evaluates risks of maternal ZIKV infection, maternal‐fetal transmission, congenital Zika syndrome (CZS), other adverse perinatal outcomes, and long‐term sequelae among pregnancies exposed to ZIKV. This review also provides contemporary criteria and guidelines for the follow‐up of exposed fetuses, based on prenatal and postnatal features of CZS.

show abstract

Population‐based surveillance for birth defects potentially related to Zika virus infection including 3‐year mortality and developmental outcomes, and Early Intervention Program service use—New York City, 2016 birth cohort

McVeigh,

Tseyang,

Vachon

et al. 2024

Birth Defects Research

View full text Add to dashboard Cite

BackgroundIn response to the 2015–2017 Zika virus outbreak, New York City (NYC) identified and monitored infants with birth defects potentially related to congenital Zika virus.MethodsAdministrative data matches were used to describe the birth characteristics of children born in 2016 meeting screening criteria for birth defects potentially related to congenital Zika virus infection relative to other NYC births and to monitor mortality and Early Intervention Program use through age 2.ResultsAmong 120,367 children born in NYC in 2016, 463 met screening criteria and 155 met the Centers for Disease Control and Prevention's case definition for birth defects potentially related to congenital Zika virus infection (1.3 per 1000; 95% confidence interval [CI], 1.1–1.5). Post‐neonatal deaths occurred among 7.7% of cases (12) and 5.2% of non‐cases (8). Odds of referral to the Early intervention Program among children who met screening criteria were lower among children of mothers who were married (OR, 0.60; 95% CI, 0.37–0.97) and among children not classified as cases whose mothers were born in Latin America and the Caribbean (OR, 0.59; 95% CI, 0.37–1.09).DiscussionPrevalence of birth defects potentially related to congenital Zika virus infection was similar to that seen in other jurisdictions without local transmission. Birth defects attributable to congenital Zika virus infection may also have been present among screened children who did not meet the case definition.

show abstract

Zika Virus Infection Among Pregnant Women and Their Neonates in New York City, January 2016–June 2017

Cited by 22 publications

References 21 publications

Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain

Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain

Zika virus during pregnancy: From maternal exposure to congenital Zika virus syndrome

Population‐based surveillance for birth defects potentially related to Zika virus infection including 3‐year mortality and developmental outcomes, and Early Intervention Program service use—New York City, 2016 birth cohort

Contact Info

Product

Resources

About