Zika virus detection in urine from patients with Guillain-Barré syndrome on Martinique, January 2016

Rozé, B.; Najioullah, Fatiha; Fergé, Jean-Louis; Apétsè, Kossivi; Brouste, Yannick; Césaire, Raymond; Fagour, C.; Fagour, Laurence; Hochedez, Patrick; Jeannin, S.; Joux, Julien; Mehdaoui, Hossein; Valentino, Ruddy; Signaté, Aïssatou; Cabie, André

doi:10.2807/1560-7917.es.2016.21.9.30154

Cited by 109 publications

(85 citation statements)

References 7 publications

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“…Up to present, studies describing the role of ZIKV in GBS have focused on outbreak areas and symptomatic ZIKV patients 4, 5, 8, 9, 25, 26, 27. Interestingly, ZIKV infections are symptomatic in only an estimated 20% of cases and ZIKV will probably soon be endemic in most affected areas.…”

Section: Discussionmentioning

confidence: 99%

“…The first study reporting on the association between ZIKV and GBS indicated that ZIKV infections were exclusively associated with axonal GBS, whereas recent reports from Brazil and Colombia show that AIDP is the subtype of GBS associated with ZIKV infection 5, 8, 25, 26, 27. Some of this variety may be attributed to retrospective analysis of nonstandardized clinical and electrophysiological data to describe subtypes of GBS.…”

Section: Discussionmentioning

confidence: 99%

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Zika virus and Guillain–Barré syndrome in Bangladesh

GeurtsvanKessel

Islam

et al. 2018

Ann Clin Transl Neurol

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ObjectivePrevious studies have associated Guillain–Barré syndrome (GBS) with Zika virus (ZIKV) outbreaks in South America and Oceania. In Asia, ZIKV is known to circulate widely, but the association with Guillain–Barré syndrome is unclear. We investigated whether endemic ZIKV infection is associated with the development of GBS.MethodsA prospective study was conducted from 2011 to 2015 in Bangladesh. A total of 418 patients and 418 healthy family controls were included in the study. Patients were diagnosed with GBS prior to inclusion according to established criteria. Detailed information on the epidemiology, clinical presentation, electrophysiology, diagnosis, disease severity, and clinical course were obtained during a follow‐up of 1 year using a predefined protocol.Results ZIKV‐neutralizing antibodies were detected in our study from 2013 onwards. The prevalence of ZIKV‐neutralizing antibodies was not significantly higher in patients with GBS compared to healthy controls (OR 2.23, P = 0.14, 95% CI 0.77–6.53). Serological evidence for prior ZIKV infection in patients with GBS was associated with more frequent cranial, sensory, and autonomic nerve involvement compared to GBS patients with Campylobacter jejuni, the predominant preceding infection in GBS worldwide. Nerve‐conduction studies revealed that ZIKV antibodies were associated with a demyelinating subtype of GBS, while C. jejuni infections were related to an axonal subtype.InterpretationNo significant association was found between ZIKV infection and GBS in Bangladesh, but GBS following ZIKV infection was characterized by a distinct clinical and electrophysiological subtype compared to C. jejuni infection. These findings indicate that ZIKV may precede a specific GBS subtype but the risk is low.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Zika virus and Guillain–Barré syndrome in Bangladesh

GeurtsvanKessel

Islam

et al. 2018

Ann Clin Transl Neurol

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“…Importantly, ZIKV is detectable for a longer time frame post-infection in urine than serum (7 or more days after becoming undetectable in serum) [38] and at a higher viral load in urine (up to 220 × 10 6 copies/mL) than in corresponding serum samples (up to 8.1 × 10 6 copies/ mL) [42]. Other groups have also reported either a longer detection window or an increased ZIKV detection in urine over other bodily fluids on a case study basis (Tables 1 and 2) [30,37,[43][44][45][46], although there have been cases where ZIKV was detected in the serum but not urine [47]. A larger cohort of paired serum and urine samples would be beneficial to support these findings.…”

Section: Advantages Of Non-invasive Sample Collectionsmentioning

confidence: 99%

Advantage of urine based molecular diagnosis of Zika virus

Lamb

Bartolone²,

Kutluay

et al. 2016

Int Urol Nephrol

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“…Although acute coinfection with DENV and ZIKV cannot be ruled out on the basis of the diagnostic tests performed, the finding of ZIKV in the urine confirms the diagnosis of ZIKV-associated GBS. 28,29 The fact that his serum PCR was negative for ZIKV on day 4 of illness but urine PCR was positive on day 18 is not surprising; viral persistence in urine has been documented in multiple prior studies. 30,31 The viremia associated with ZIKV infection is thought to be relatively low titer and short lived, lasting only 2-3 days and waning with the onset of rash.…”

Section: Discussionmentioning

confidence: 99%

Guillain–Barré Syndrome Associated with Zika Virus Infection in a Traveler Returning from Guyana

Fabrizius

Anderson

Hendel-Paterson

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Zika virus (ZIKV) is a mosquito-borne flavivirus with a significant public health impact highlighted by the ongoing epidemic in the Americas. We describe a 44-year-old male presenting to our tropical medicine center with complaints of fever, headache, joint pain, and rash after recent travel to Guyana. The patient subsequently developed gait imbalance and lower extremity weakness with clinical examination, cerebrospinal fluid studies, and magnetic resonance imaging of the spine consistent with a diagnosis of Guillain-Barré syndrome (GBS). ZIKV infection was confirmed via detection of ZIKV RNA in urine by polymerase chain reaction. The patient was treated with intravenous immunoglobulin and experienced near-complete neurologic recovery, reporting ongoing mild paresthesia up to 2 months later. This case highlights the diagnostic challenges posed by ZIKV and underscores the need for clinician awareness of the potential for neurological complications such as GBS with ZIKV infection. BACKGROUND

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Zika virus detection in urine from patients with Guillain-Barré syndrome on Martinique, January 2016

Cited by 109 publications

References 7 publications

Zika virus and Guillain–Barré syndrome in Bangladesh

Zika virus and Guillain–Barré syndrome in Bangladesh

Advantage of urine based molecular diagnosis of Zika virus

Guillain–Barré Syndrome Associated with Zika Virus Infection in a Traveler Returning from Guyana

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