Zika virus complete genome from Salvador, Bahia, Brazil

Giovanetti, Marta; Faria, Nuno Rodrigues; Nunes, Márcio Roberto Teixeira; Vasconcelos, Janaína Mota de; Lourenço, José; Rodrigues, Sueli Guerreiro; Vianez, João; Silva, Sandro Patroca da; Lemos, Poliana Silva; Tavares, Fernando Neto; Martin, Darren P.; Rosário, Mateus Santana do; Siqueira, Isadora Cristina de; Ciccozzi, Massimo; Pybus, Oliver G.; Oliveira, Túlio de; Alcântara, Luíz Carlos Júnior

doi:10.1016/j.meegid.2016.03.030

Cited by 26 publications

(20 citation statements)

References 14 publications

(16 reference statements)

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“…Microcephalic infants with a presumed diagnosis of congenital ZIKV infection were recruited through an active search in December 2015 in Salvador and Sao Paulo, Brazil (203). All other infections were ruled out (TORCH, HIV).…”

Section: Other Fetal and Neonatal Anomaliesmentioning

confidence: 99%

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

et al. 2016

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SUMMARYThe rapid spread of the Zika virus (ZIKV) in the Americas and its potential association with thousands of suspected cases of microcephaly in Brazil and higher rates of Guillain-Barré syndrome meet the conditions for a Public Health Emergency of International Concern, as stated by the World Health Organization in February 2016. Two months later, the Centers for Disease Control and Prevention (CDC) announced that the current available evidence supports the existence of a causal relationship between prenatal Zika virus infection and microcephaly and other serious brain anomalies. Microcephaly can be caused by several factors, and its clinical course and prognosis are difficult to predict. Other pathogens with proven teratogenicity have been identified long before the current ZIKV epidemic. Despite the growing number of cases with maternal signs of infection and/or presence of ZIKV in tissues of affected newborns or fetuses, it is currently difficult to assess the magnitude of increase of microcephaly prevalence in Brazil, as well as the role of other factors in the development of congenital neurological conditions. Meanwhile, health agencies and medical organizations have issued cautious guidelines advising health care practitioners and expectant couples traveling to, returning from, or living in affected areas. Analogous to dengue virus (DENV) epidemics, ZIKV has the potential to become endemic in all countries infested byAedesmosquitoes, while new mutations could impact viral replication in humans, leading to increased virulence and consequently heightened chances of viral transmission to additional naive mosquito vectors. Studies are urgently needed to answer the questions surrounding ZIKV and its role in congenital neurological conditions.

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Section: Other Fetal and Neonatal Anomaliesmentioning

confidence: 99%

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

et al. 2016

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“…In addition, we append to our dataset 115 publicly available sequences and 85 additional genomes from ref. 21. The final dataset comprised 254 ZIKV sequences, 241 of which were sampled in the Americas (see Methods).…”

mentioning

confidence: 99%

Establishment and cryptic transmission of Zika virus in Brazil and the Americas

Faria

Quick

Claro

et al. 2017

Nature

531

485

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Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in northeast Brazil1. Brazil has had the highest number of reported ZIKV cases worldwide (more than 200,000 by 24 December 20162) and the most cases associated with microcephaly and other birth defects (2,366 confirmed by 31 December 20162). Since the initial detection of ZIKV in Brazil, more than 45 countries in the Americas have reported local ZIKV transmission, with 24 of these reporting severe ZIKV-associated disease3. However, the origin and epidemic history of ZIKV in Brazil and the Americas remain poorly understood, despite the value of this information for interpreting observed trends in reported microcephaly. Here we address this issue by generating 54 complete or partial ZIKV genomes, mostly from Brazil, and reporting data generated by a mobile genomics laboratory that travelled across northeast Brazil in 2016. One sequence represents the earliest confirmed ZIKV infection in Brazil. Analyses of viral genomes with ecological and epidemiological data yield an estimate that ZIKV was present in northeast Brazil by February 2014 and is likely to have disseminated from there, nationally and internationally, before the first detection of ZIKV in the Americas. Estimated dates for the international spread of ZIKV from Brazil indicate the duration of pre-detection cryptic transmission in recipient regions. The role of northeast Brazil in the establishment of ZIKV in the Americas is further supported by geographic analysis of ZIKV transmission potential and by estimates of the basic reproduction number of the virus.

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“…Apart from ZIKV, the Flavivirus genus also includes the yellow fever virus (YFV), West Nile Virus (WNV), Japanese encephalitis virus (JEV), Chikungunya virus (CHKV), tick-borne encephalitis virus (TBEV), and Dengue virus (DENV), many of which are commonly associated with CNS complications (Neal 2014; Sips et al 2012). The ZIKV genome is >10 Kb in length and contains a single open reading frame (ORF) that codes for capsid (C), precursor membrane (PrM), envelope (E), and seven non-structural proteins formed NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5 (Cunha et al 2016; Ellison et al 2016; Enfissi et al 2016; Giovanetti et al 2016; Ladner et al 2016; Liu et al 2016; Nandy et al 2016). The envelop protein of ZIKV possesses close resemblance with all of the 4 serotypes of Dengue virus (DENV), having 54–58% of homology (Kostyuchenko et al 2016) leading to serological crossreactivity (Lanciotti et al 2008).…”

mentioning

confidence: 99%

Zika Virus Infection and Development of a Murine Model

Shah

Kumar

2016

Neurotox Res

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In view of the recent outbreak of Zika Virus (ZIKV), there is an urgent need to investigate pathogenesis of the symptoms associated with ZIKV infection. Since the first identification of the virus in 1947, the pathologies associated with ZIKV infection were thought to be limited with mild illness that presented fever, rashes, muscle aches, and weakness. However, ZIKV infection has been shown to cause Guillain-Barré Syndrome (GBS), and numerous cases of congenital microcephaly in children have been reported when pregnant females were exposed to the virus. The severity and the rate of spread of ZIKV in the last year has drawn alarming interest among researchers to investigate murine models to study viral pathogenesis and develop candidate vaccines. A recent study by Lazear colleagues in the May 2016 issue of cell host and microbe, is an effort to study the pathogenesis of contemporary and historical virus strains in various mouse models.

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Zika virus complete genome from Salvador, Bahia, Brazil

Cited by 26 publications

References 14 publications

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

Establishment and cryptic transmission of Zika virus in Brazil and the Americas

Zika Virus Infection and Development of a Murine Model

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