Zika virus co-opts microRNA networks to persist in placental niches detected by spatial transcriptomics

Barrozo, Enrico R.; Seferovic, Maxim D.; Hamilton, Mark P.; Moorshead, David N.; Jochum, Michael D.; Do, Trang; O’Neil, Derek S.; Suter, Melissa A.; Aagaard, Kjersti M.

doi:10.1016/j.ajog.2023.08.012

American Journal of Obstetrics and Gynecology

2024

DOI: 10.1016/j.ajog.2023.08.012

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Zika virus co-opts microRNA networks to persist in placental niches detected by spatial transcriptomics

Enrico R. Barrozo,

Maxim D. Seferovic,

Mark P. Hamilton

et al.

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Insights into Zika Virus Pathogenesis and Potential Therapeutic Strategies

Camacho-Concha,

Santana-Román,

Sánchez

et al. 2023

Biomedicines

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Zika virus (ZIKV) has emerged as a significant public health threat, reaching pandemic levels in 2016. Human infection with ZIKV can manifest as either asymptomatic or as an acute illness characterized by symptoms such as fever and headache. Moreover, it has been associated with severe neurological complications in adults, including Guillain–Barre syndrome, and devastating fetal abnormalities, like microcephaly. The primary mode of transmission is through Aedes spp. mosquitoes, and with half of the world’s population residing in regions where Aedes aegypti, the principal vector, thrives, the reemergence of ZIKV remains a concern. This comprehensive review provides insights into the pathogenesis of ZIKV and highlights the key cellular pathways activated upon ZIKV infection. Additionally, we explore the potential of utilizing microRNAs (miRNAs) and phytocompounds as promising strategies to combat ZIKV infection.

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Insights into Zika Virus Pathogenesis and Potential Therapeutic Strategies

Camacho-Concha,

Santana-Román,

Sánchez

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

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Zika virus co-opts microRNA networks to persist in placental niches detected by spatial transcriptomics

Cited by 1 publication

References 111 publications

Insights into Zika Virus Pathogenesis and Potential Therapeutic Strategies

Insights into Zika Virus Pathogenesis and Potential Therapeutic Strategies

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