Zika Virus and the Guillain–Barré Syndrome — Case Series from Seven Countries

Santos, Thaís dos; Rodríguez, Angel; Almirón, María; Sanhueza, Antonio; Ramon, Pilar; Oliveira, Wanderson Kleber de; Coelho, Giovanini Evelim; Badaro, Roberto; Cortez, Juan Fariño; Ospina, Martha; Pimentel, Raquel; Masis, Rolando; Hernández, F; Lara, Bredy; Montoya, Romeo; Jubithana, Beatrix; Melchor, Angel; Alvarez, Angel; Aldighieri, Sylvain; Dye, Christopher; Espinal, Marcos

doi:10.1056/nejmc1609015

Cited by 296 publications

(230 citation statements)

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“…It is not known why Zika virus disease incidence is higher among women aged ≥20 years. Similar observations have been made in Bahia state (Brazil) and El Salvador, where, overall, the reported incidence of clinically suspected Zika virus disease cases was 75% higher in females than in males (7). In addition, rates of probable Zika virus disease cases in Bahia state and El Salvador were highest in women aged 20-49 years (7), the same age group most highly affected in Puerto Rico.…”

Section: Discussionsupporting

confidence: 67%

“…Similar to Puerto Rico, 61% of confirmed or probable Zika virus infections in Yap occurred among females (8). The skewing of the distribution of Zika virus disease cases toward women in Brazil was postulated to be because of more exposure to Aedes mosquitoes in the home, more severe symptoms among women in certain age groups, differences in health care-seeking behavior, reporting biases by health care workers, and sexual transmission (7,9). Although male-to-female and female-to-male (10) sexual transmission has been documented, data from Rio de Janeiro suggest that differences in infection rates between men and women might be explained by male-to-female sexual transmission (9).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence of Zika Virus Disease by Age and Sex — Puerto Rico, November 1, 2015–October 20, 2016

Lozier¹,

Adams²,

Febo³

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Incidence of Zika Virus Disease by Age and Sex — Puerto Rico, November 1, 2015–October 20, 2016

Lozier¹,

Adams²,

Febo³

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

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“…GBS is an acute polyradiculoneuropathy causing a rapidly progressive limb weakness and is triggered by various types of preceding infection 6. Recently, the association between ZIKV and GBS has also been reported in various Latin‐American countries following outbreaks of ZIKV 4, 7, 8, 9. In Asia, where ZIKV has been endemic for several decades,10, 11, 12 the occurrence of GBS and other neurological complications after ZIKV infection have thus far not been reported.…”

Section: Introductionmentioning

confidence: 99%

Zika virus and Guillain–Barré syndrome in Bangladesh

GeurtsvanKessel

Islam

et al. 2018

Ann Clin Transl Neurol

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ObjectivePrevious studies have associated Guillain–Barré syndrome (GBS) with Zika virus (ZIKV) outbreaks in South America and Oceania. In Asia, ZIKV is known to circulate widely, but the association with Guillain–Barré syndrome is unclear. We investigated whether endemic ZIKV infection is associated with the development of GBS.MethodsA prospective study was conducted from 2011 to 2015 in Bangladesh. A total of 418 patients and 418 healthy family controls were included in the study. Patients were diagnosed with GBS prior to inclusion according to established criteria. Detailed information on the epidemiology, clinical presentation, electrophysiology, diagnosis, disease severity, and clinical course were obtained during a follow‐up of 1 year using a predefined protocol.Results ZIKV‐neutralizing antibodies were detected in our study from 2013 onwards. The prevalence of ZIKV‐neutralizing antibodies was not significantly higher in patients with GBS compared to healthy controls (OR 2.23, P = 0.14, 95% CI 0.77–6.53). Serological evidence for prior ZIKV infection in patients with GBS was associated with more frequent cranial, sensory, and autonomic nerve involvement compared to GBS patients with Campylobacter jejuni, the predominant preceding infection in GBS worldwide. Nerve‐conduction studies revealed that ZIKV antibodies were associated with a demyelinating subtype of GBS, while C. jejuni infections were related to an axonal subtype.InterpretationNo significant association was found between ZIKV infection and GBS in Bangladesh, but GBS following ZIKV infection was characterized by a distinct clinical and electrophysiological subtype compared to C. jejuni infection. These findings indicate that ZIKV may precede a specific GBS subtype but the risk is low.

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“…Moreover, the infection consequences in newborns can cause a range of different pathologies, which were described as the congenital Zika syndrome (Martines et al, 2016). ZIKV may additionally be associated with other neurological complications affecting adults, such as Guillain-Barré Syndrome (Dos Santos et al, 2016). Beyond to newborn disorders, the main symptoms of ZIKV infection are maculopapular rash, fatigue, lethargy, asthenia, fever, arthritis, arthralgia, myalgia, conjunctivitis and headache.…”

Section: Zika Virus Infectionmentioning

confidence: 99%

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2018

Safety Assessment of Transgenic Organisms in the Environment, Volume 8

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This work is published under the responsibility of the Secretary-General of the OECD. The opinions expressed and arguments employed herein do not necessarily reflect the official views of OECD member countries.This document, as well as any data and any map included herein, are without prejudice to the status of or sovereignty over any territory, to the delimitation of international frontiers and boundaries and to the name of any territory, city or area.Please cite this publication as: OECD (2018) The statistical data for Israel are supplied by and under the responsibility of the relevant Israeli authorities. The use of such data by the OECD is without prejudice to the status of the Golan Heights, East Jerusalem and Israeli settlements in the West Bank under the terms of international law.Photo credits: Cover © Maks Ershov.Corrigenda to OECD publications may be found on line at: www.oecd.org/about/publishing/corrigenda.htm. © OECD 2018You can copy, download or print OECD content for your own use, and you can include excerpts from OECD publications, databases and multimedia products in your own documents, presentations, blogs, websites and teaching materials, provided that suitable acknowledgment of the source and copyright owner(s) is given. All requests for public or commercial use and translation rights should be submitted to rights@oecd.org. Requests for permission to photocopy portions of this material for public or commercial use shall be addressed directly to the Copyright Clearance Center (CCC) at info@copyright.com or the Centre francais d'exploitation du droit de copie (CFC) at contact@cfcopies.com. FOREWORD │ 3SAFETY ASSESSMENTOF TRANSGENIC ORGANISMSIN THE ENVIRONMENT, VOLUME 8 © OECD 2018 ForewordModern biotechnologies are applied to plants species (crops, flowers, trees), animals and micro-organisms. The safety of the resulting transgenic organisms when released in the environment for their use in agriculture, forestry, the food and feed industry or for other applications represents a challenging issue. Genetically engineered products are rigorously assessed by their developers during their elaboration, and by governments when ready for release, to ensure high safety standards. This remains essential with new biotechnology developments using insects to fight against disease outbreaks: engineered mosquitoes need to be evaluated through a scientifically sound approach to risk/safety assessment that will inform biosafety regulators and support the decision concerning the release of these novel organisms in the environment.The OECD offers a long-standing recognised expertise in biosafety and contributes to facilitating an harmonised approach. The OECD's Working Group on Harmonisation of Regulatory Oversight in Biotechnology (WG-HROB) was established in 1995. The WG-HROB gathers national authorities responsible for the environmental risk/safety assessment of products of modern biotechnology in OECD countries and other economies. International organisations and experts involved in biosafety activities are a...

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Zika Virus and the Guillain–Barré Syndrome — Case Series from Seven Countries

Cited by 296 publications

References 5 publications

Incidence of Zika Virus Disease by Age and Sex — Puerto Rico, November 1, 2015–October 20, 2016

Incidence of Zika Virus Disease by Age and Sex — Puerto Rico, November 1, 2015–October 20, 2016

Zika virus and Guillain–Barré syndrome in Bangladesh

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