Zika convalescent macaques display delayed induction of anamnestic cross-neutralizing antibody responses after dengue infection

Valiant, William G.; Huang, Yan-Jang S.; Vanlandingham, Dana L.; Higgs, Stephen; Lewis, Mark G.; Mattapallil, Joseph J.

doi:10.1038/s41426-018-0132-z

Cited by 23 publications

(22 citation statements)

References 31 publications

(33 reference statements)

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“…Further characterization of ZIKV early convalescent sera from these macaques indicated that there is a delayed induction of the cross-reactive Ab response against DENV, supporting no cross-protection against the outcome of DENV infection 39 . Despite these findings, further studies are needed to dissect the complementary role of the innate, humoral and cellular immune response to mechanistically explain these findings.…”

Section: Introductionmentioning

confidence: 92%

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Pérez-Guzmán

Pantoja

Serrano-Collazo

et al. 2019

Preprint

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34The role of Zika virus (ZIKV) immunity on subsequent dengue virus (DENV) infections is 35 relevant to anticipate the dynamics of forthcoming DENV epidemics in areas with previous ZIKV 36 exposure. We study the effect of ZIKV infection with various strains on subsequent DENV 37 immune response after 10 and 2 months of ZIKV infection in rhesus macaques. Our results 38show that a subsequent DENV infection in animals with early-and middle-convalescent periods 39 to ZIKV do not promote an increase in DENV viremia nor pro-inflammatory status. Previous 40 ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV, 41 and different time intervals between infections alter the magnitude and durability of such 42 responses-more after longer ZIKV pre-exposure. Collectively, we find no evidence of a 43 detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the 44 implementation of ZIKV vaccines that could also boost immunity against future DENV 45 epidemics. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61Zika virus (ZIKV) is a re-emerging mosquito-borne Flavivirus that has captivated the 62 attention of the scientific community by its explosive spread in The Americas 1 , and severe 63 neurological sequelae following infection 2-4 . ZIKV established itself in tropical and sub-tropical 64 regions that are endemic to other closely-related flaviviruses such as dengue virus (DENV). 65Both viruses belong to the Flaviviridae family and are transmitted by Aedes spp. mosquitoes. 66DENV is a global public health threat, having two-thirds of world's population at risk of infection, 67 causing ~390 million infections annually 5,6 . DENV exists as four genetically similar but 68 antigenically different serotypes (DENV1-4) 7 . Exposure to one DENV serotype confers long-69 lived immunity against a homotypic secondary infection. However, secondary infection with a 70 heterologous serotype of DENV is the major risk factor to induce severe DENV disease [8][9][10] . 71Due to the antigenic similarities between DENV and ZIKV, concerns have been raised 72 regarding the impact of DENV-ZIKV cross-reactive immunity on the development of severe 73 clinical manifestations 11,12 . It has been demonstrated that DENV-immune sera from humans can 74 enhance ZIKV infection in vitro 13,14 , and in vivo in immune-deficient mouse models 15 . However, 75 recent results from our group and others have shown that previous flavivirus exposure-76including DENV-may have no detrimental impact on ZIKV infection in vivo in non-human 77 primates (NHP) 16,17 and humans 18 . Moreover, these studies and others suggest that previous 78 DENV immunity may play a protective role during ZIKV infection involving humoral and cellular 79 responses 19-23 . On the other hand, little is known about the opposite scenario, the role of a 80 previous ZIKV exposure on subsequent DENV infection, which is relevant to anticipate the 81 dynamics of forthcoming DENV epidemics. 82The recent ZIKV epidemic in the Americas resulted in t...

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Section: Introductionmentioning

confidence: 92%

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Pérez-Guzmán

Pantoja

Serrano-Collazo

et al. 2019

Preprint

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“…Other groups also have found no evidence of enhancement of ZIKV pathogenesis in DENV-immune macaques 194,195 . However, in a study in rhesus macaques, prior exposure to ZIKV resulted in enhanced DENV peak viraemia 196 , and this was associated with delayed induction of memory cross-neutralizing antibody responses 197 . This observation may have implications for ZIKV vaccine development in areas endemic for DENV infections.…”

Section: Emerging and Re-emerging Threatsmentioning

confidence: 99%

The continued threat of emerging flaviviruses

Pierson

Diamond²

2020

Nat Microbiol

668

627

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F laviviruses are single-stranded RNA viruses vectored principally by arthropods that cause severe illnesses in humans. The extensive global spread and epidemic transmission of flaviviruses during the last seven decades has been remarkable. The mosquito-borne dengue viruses (DENV) infect an estimated 400 million humans each year; more than a quarter of the world's population lives in areas where DENV is now endemic 1 . By comparison, only sporadic DENV epidemics were documented before the Second World War 2 . The introductions of West Nile (WNV) and Zika (ZIKV) viruses into the Western Hemisphere was followed by rapid geographical spread, large numbers of human infections and considerable morbidity 3,4 . Ongoing yellow fever virus (YFV) transmission and its encroachment on urban environments, despite the existence of an effective vaccine, poses a serious public health challenge 5-7 . Other flaviviruses present ongoing health risks or are beginning to emerge in different parts of the world, including Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV) and Usutu virus (USUV).The epidemic potential of flaviviruses reflects many factors related to the unique characteristics of their insect vectors, the consequences of poorly planned urbanization that creates ideal arthropod breeding habitats, the geographical expansion of vectors, changing environmental conditions and extensive global travel 8,9 . Beyond arthropods and humans, flaviviruses are also known to infect a wide array of animal species and can be important veterinary pathogens that threaten economically important domesticated animals 10-14 . These vertebrate animal hosts may constitute important stable reservoirs and contribute to defining conditions that support the introduction of new viral species and transmission among humans 15 . The continued threat of flavivirus emergence and re-emergence highlights a need for a detailed fundamental understanding of the biology of these viruses, the immune responses that can contain them and the possible countermeasures that can blunt their impact on public health should new outbreaks occur. Flavivirus structure and replicationFlaviviruses are small (~50 nm) spherical virus particles that incorporate a single genomic RNA of positive-sense polarity encoding three structural and seven non-structural proteins (Fig. 1a). Our knowledge of the biology of flaviviruses has advanced considerably with the availability of high-resolution structures of viral structural proteins and of virions at different stages of the replication cycle or in complex with antibodies or host factors 16 . Crystal structures of the enzymatic non-structural proteins also have been solved, accelerating advances in an understanding of virus replication and pathogenesis [17][18][19] and enabling structure-guided drug discovery, as reviewed elsewhere 20 .Virion structure and morphogenesis. Flaviviruses are assembled using three viral structural proteins (C, prM and E), a host lipid envelope and the viral genomic RNA. The structure of ...

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“…On the other hand, observations from arbovirus surveillance in Brazil suggest a decrease in DENV circulation after the ZIKV outbreak, possibly due to DENV cross-neutralization by ZIKV antibodies [80]. Additionally, there are indications that these cross-neutralizing ZIKV antibodies can prevent DENV ADE [81, 82]. However, for DENV, it is demonstrated that the risk of severe disease depends on the titer of preexisting DENV antibodies [16].…”

Section: Enhancement Of Denv By Zikv Antibodiesmentioning

confidence: 99%

“…However, for DENV, it is demonstrated that the risk of severe disease depends on the titer of preexisting DENV antibodies [16]. Therefore, it is plausible that cross-neutralizing ZIKV antibodies can prevent DENV ADE, whereas cross-reactive, binding ZIKV antibodies can enhance DENV infection, stressing the importance of measuring the balance between neutralizing and nonneutralizing antibodies in studies on pathogenesis [81]. The possibility of DENV ADE by ZIKV antibodies is especially of importance in DENV-naïve persons who live in DENV-endemic areas and who have had a previous ZIKV infection.…”

Section: Enhancement Of Denv By Zikv Antibodiesmentioning

confidence: 99%

The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis

et al. 2019

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Zika virus (ZIKV) has been known for decades to circulate in Africa and Asia. However, major complications of a ZIKV infection have recently become apparent for reasons that are still not fully elucidated. One of the hypotheses for the seemingly increased pathogenicity of ZIKV is that cross-reactive dengue antibodies can enhance a ZIKV infection through the principle of antibody-dependent enhancement (ADE). Recently, ADE in ZIKV infection has been studied, but conclusive evidence for the clinical importance of this principle in a ZIKV infection is lacking. Conversely, the widespread circulation of ZIKV in dengue virus (DENV)-endemic regions raises new questions about the potential contribution of ZIKV antibodies to DENV ADE. In this review, we summarize the results of the evidence to date and elaborate on other possible detrimental effects of cross-reactive flavivirus antibodies, both for ZIKV infection and the risk of ZIKV-related congenital anomalies, DENV infection, and dengue hemorrhagic fever.

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Zika convalescent macaques display delayed induction of anamnestic cross-neutralizing antibody responses after dengue infection

Cited by 23 publications

References 31 publications

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

The continued threat of emerging flaviviruses

The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis

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