ZIGOMICOSIS CUTANEA PRIMARIA POR Rhyzopus oryzae EN UNA NIÑA CON LEUCEMIA LINFOBLASTICA AGUDA TIPO B

Salim, R.; Runco, Rosa; Alvarez, C; Romano, Simone; Charre, M

doi:10.22370/bolmicol.2008.23.0.120

Bol. Micol.

2008

DOI: 10.22370/bolmicol.2008.23.0.120

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ZIGOMICOSIS CUTANEA PRIMARIA POR Rhyzopus oryzae EN UNA NIÑA CON LEUCEMIA LINFOBLASTICA AGUDA TIPO B

R. Salim

Rosa Runco

C Alvarez

et al.

Abstract: RESUMEN La Zigomicosis es una infección infrecuente causada por hongos oportunistas integrantes del orden ABSTRACT Zygomycosis is an infrequent infection caused by opportunistic fungi which belong to the order Mucorales and which is present in high risk

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2023

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Primary cutaneous mucormycosis due to Rhizopus arrhizus in an immunosuppressed patient with paroxysmal nocturnal haemoglobinuria

Osorio‐Aragón,

Toussaint‐Caire,

Guzmán‐Bucio

et al. 2023

Tropical Med Int Health

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Objective We present a case of primary cutaneous mucormycosis in a patient with bone marrow failure secondary to paroxysmal nocturnal haemoglobinuria (PNH). Clinical case A 60‐year‐old male patient with a history of PNH, complicated to a severe aplastic anaemia, presented to the emergency department complaining of papules on the lower limbs that rapidly turned into necrotic plaques within 2 months. Histopathological examination showed granulomatous and suppurative dermatitis with tissue necrosis and the presence of non‐septate hyphae. Molecular identification was achieved by amplification and sequencing of the 18S‐ITS1‐5.8S‐ITS2‐28S rRNA region using the polymerase chain reaction. The sequence showed 100% identity with Rhizopus arrhizus. The patient received treatment with liposomal amphotericin B and surgical debridement. Nonetheless, the patient suffered from severe low red blood cells and platelets and also underwent septic shock; he died 6 days after admission to the hospital. Conclusion Mucormycosis in the setting of immunosuppression is challenging. Upon suspicion of a diagnosis, immediate treatment is required. Adjunctive therapies may be considered; however, the case fatality rate remains high.

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Primary cutaneous mucormycosis due to Rhizopus arrhizus in an immunosuppressed patient with paroxysmal nocturnal haemoglobinuria

Osorio‐Aragón,

Toussaint‐Caire,

Guzmán‐Bucio

et al. 2023

Tropical Med Int Health

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show abstract

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ZIGOMICOSIS CUTANEA PRIMARIA POR Rhyzopus oryzae EN UNA NIÑA CON LEUCEMIA LINFOBLASTICA AGUDA TIPO B

Abstract: RESUMEN La Zigomicosis es una infección infrecuente causada por hongos oportunistas integrantes del orden ABSTRACT Zygomycosis is an infrequent infection caused by opportunistic fungi which belong to the order Mucorales and which is present in high risk

Cited by 1 publication

References 19 publications

Primary cutaneous mucormycosis due to Rhizopus arrhizus in an immunosuppressed patient with paroxysmal nocturnal haemoglobinuria

Primary cutaneous mucormycosis due to Rhizopus arrhizus in an immunosuppressed patient with paroxysmal nocturnal haemoglobinuria

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