Zieve Syndrome in a Patient With Hepatitis C

Haider, Asad A; Salabei, Joshua K.; Hashmi, Mariam; Ismail, Zeeshan; Zheng, Mingyue; Iyer, Uma G

doi:10.7759/cureus.25412

Cited by 2 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unconventional therapies such as plasmapheresis in a patient with massive elevations in triglyceride have also been reported [ 17 ]. It is believed that the commonly used scoring system of Maddrey discriminant function, which screens alcoholic patients who benefit from steroids, is ineffective in Zieve syndrome due to the temporary elevations in bilirubin levels that normalize after alcohol cessation [ 18 ]. In fact, the recommendation is to avoid corticosteroids entirely due to a lack of any proven efficacy [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Unique Variant of Zieve Syndrome With a Normal Reticulocyte Count

et al. 2023

View full text Add to dashboard Cite

Zieve syndrome is a rare diagnosis seen in patients with chronic alcohol use which consists of a distinct clinical triad of hyperlipidemia, hemolytic anemia, and jaundice. Patients typically have an elevated reticulocyte count due to the hemolytic nature of the anemia. We present the case of a 44-year-old female who was discovered to have an unusual variant of Zieve syndrome with a normal reticulocyte count, which was believed to be due to suppression of bone marrow from excessive alcohol consumption. She was treated with steroids and complete alcohol cessation, with remarkable improvement on subsequent follow-up. An exhaustive literature review of 31 documented cases of Zieve syndrome was conducted to better understand the clinical presentation and overall prognosis of these patients. This case report and literature review aimed to improve patient outcomes through increased recognition of this underrecognized syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

Unique Variant of Zieve Syndrome With a Normal Reticulocyte Count

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Additionally, this rise appears less extensive in patients with more advanced cirrhosis [1], as with this patient. There have been other recent cases reported with normal lipid profiles [8].…”

Section: Discussionmentioning

confidence: 96%

Zieve’s Syndrome: An Underdiagnosed Cause of Non-immune Hemolytic Anemia

Ribeiro,

Ferreira,

Coelho

et al. 2024

Cureus

View full text Add to dashboard Cite

Zieve's syndrome is an underdiagnosed condition characterized by the triad of jaundice, hemolytic anemia, and hyperlipidemia in the setting of chronic alcohol use. It may be accompanied by acute alcoholic hepatitis. The distinction between the coexistence of acute alcoholic hepatitis with Zieve's syndrome and Zieve's syndrome in isolation is crucial, given the different treatments and prognoses in these situations.A 35-year-old woman presented with complaints of abdominal discomfort, nausea, and vomiting in the previous week. She was a heavy drinker with resultant cirrhosis, splenomegaly, and esophageal varices. An ancillary test showed hemolytic anemia, moderately elevated transaminases, hyperbilirubinemia, and coagulopathy. A negative direct Coombs test established the anemia as non-immune, supporting the diagnosis of Zieve's syndrome despite the absence of hyperlipidemia. Maddrey's discriminant function score was 92 points, so she was treated with supportive measures, as well as corticosteroids in the setting of acute alcoholic hepatitis. The patient showed a favorable clinical and analytical evolution and was discharged home one month following admission with her hemoglobin levels stabilized.Previous literature focused on the distinction between Zieve's syndrome and acute alcoholic hepatitis but they may coexist.

show abstract

Zieve Syndrome in a Patient With Hepatitis C

Cited by 2 publications

References 14 publications

Unique Variant of Zieve Syndrome With a Normal Reticulocyte Count

Unique Variant of Zieve Syndrome With a Normal Reticulocyte Count

Zieve’s Syndrome: An Underdiagnosed Cause of Non-immune Hemolytic Anemia

Contact Info

Product

Resources

About