ZHENG-Omics Application in ZHENG Classification and Treatment: Chinese Personalized Medicine

Abstract

With the hope to provide an effective approach for personalized diagnosis and treatment clinically, traditional chinese medicine (TCM) is being paid increasing attention as a complementary and alternative medicine. It performs treatment based on ZHENG (TCM syndrome) classification, which could be identified clinical special phenotypes by symptoms and signs of patients even if they have a different disease. However, it caused controversy because ZHENG classification only depends on observation, knowledge, and clinical experience of TCM practitioners, which lacks objectivity and repeatability. Although researchers and scientists of TCM have done some work with a lot of beneficial methods, the results could not reach satisfactory with the shortcomings of generalizing the entire state of the body or ignoring the patients' feelings. By total summary, mining, and integration of existing researches, the present paper attempts to introduce a novel macro-microconcept of ZHENG-omics, with the prospect of bright future in providing an objective and repeatable approach for Chinese personalized medicine in an effective way. In this paper, we give the brief introduction and preliminary validation, and discuss strategies and system-oriented technologies for achieving this goal.

Syndrome Differentiation of IgA Nephropathy Based on Clinicopathological Parameters: A Decision Tree Model

“…In other diseases, some model has been developed to diagnose patients' syndromes [35–40]. Some of these studies were based on syndrome factors, which comprised subjective indexes, encountering challenges of extrapolation and repeatability [36, 40].…”

“…In other diseases, some model has been developed to diagnose patients' syndromes [35–40]. Some of these studies were based on syndrome factors, which comprised subjective indexes, encountering challenges of extrapolation and repeatability [36, 40]. Cluster analysis can group the similar clinical features together, which may be related to different syndrome types; however, the similar features did not indicate cooccurrence of clinical features or symptoms [39].…”

The Need for Integrative Oncology and a Remodeling of Evidence-Based Medicine

“…Through ZHENG-Omics study, personal medicine in TCM may emerge eventually and may change the current medical system. 45 While the ZHENG/TCM approach to diagnostics might appear nonobjective, it does offer long-standing clinical and phenotypic-rich insights. With the current globalization of life sciences and the arrival of "Big Data" research and development, these two silos of medical lore are rapidly coalescing.…”

Identification of Chinese medicine syndromes in persistent insomnia associated with major depressive disorder: a latent tree analysis

“…However, these statistical approaches cannot capture the nature of CM syndromes. For example, factor analysis assumes that the observed variables are a linear combination of the latent variables (CM syndromes) and that the factors are independent of each other; however, CM syndromes might be caused by inter-related factors [ 28 ]. Cluster analysis has previously been used to group clinical feature variables [ 29 , 30 ] and to group participants [ 31 ].…”