Zeylenone inhibits proliferation and promotes apoptosis in ovarian carcinoma cells via Janus kinase 2 / signal transducers and activators of transcription 3 pathways

Xu, Xiu; Shi, Junyu; Gao, Hongyan; Qin, Li

doi:10.1111/jog.13690

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…Furthermore, the 5‐year overall survival of ovarian cancer was still less than 40% . For one reason, the pathogenesis of ovarian cancer is complex and unknown; For another reason, the lack of high fidelity ovarian cancer research model is another important aspect.…”

Section: Introductionmentioning

confidence: 99%

Establishment of patient‐derived xenograft model in ovarian cancer and its influence factors analysis

Zheng

Tian

et al. 2019

J of Obstet and Gynaecol

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Aim Patient‐derived xenograft (PDX) model has been applied to the study of breast cancer, lung cancer, colon cancer and other cancers. However, its feasibility in ovarian cancer has not been understood. This study aimed to establish ovarian cancer PDX model and reveal its influence factors. Methods In this study, 27 patients in Obstetrics and Gynecology Hospital affiliated to Fudan University from May 2015 to May 2016 were employed to explore the method of PDX model in ovarian cancer and verify its feasibility. Results Finally, five cases of PDX models were successfully established, and the tumor formation rate (TFR) was 18.52%. In addition, immunohistochemistry and transcriptome sequencing analysis showed that tumor of PDX model have similar gene expression, gene splicing, gene fusion and single nucleotide polymorphisms with primary tumor (R2 = 0.741). Furthermore, it was revealed that compared to epithelial ovarian cancer, the TFR of PDX models with nonepithelial ovarian cancer was higher, while other factors such as the initiation site of tumor, the degree of tumor malignancy, the stage of tumor, the type of tumor and the species of experimental animals were not associated with the TFR. Conclusion Ovarian cancer PDX model, as a new scientific research model, can better keep the biological characteristics of primary tumor, which has great research value in ovarian cancer.

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Section: Introductionmentioning

confidence: 99%

Establishment of patient‐derived xenograft model in ovarian cancer and its influence factors analysis

Zheng

Tian

et al. 2019

J of Obstet and Gynaecol

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“…In SKOV3 cells incubated with zeylenone at different concentrations (2.5, 5, and 10 μmol/L for 24 h), Janus family of tyrosine kinase (p-JAK), and signal transducer with activator of transcription (p-STAT) expression levels were reduced variously. In a dose-dependent pattern, zeylenone increased the loss of MMP, apoptosis-inducing factor (AIF), and cytochrome c. Apart from that, it increased caspase-3, Fas, Fasl, and Bax in both the mRNA and protein expression levels but decreased Bcl-2 expression level [ 28 ].…”

Section: Mechanisms With Natural Plants Compound In Ovarian Cancer Cellsmentioning

confidence: 99%

Mechanisms and Advances in Anti-Ovarian Cancer with Natural Plants Component

Zhou

Wang

et al. 2021

Molecules

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Ovarian cancer ranks seventh in the most common malignant tumors among female disease, which seriously threatens female reproductive health. It is characterized by hidden pathogenesis, missed diagnosis, high reoccurrence rate, and poor prognosis. In clinic, the first-line treatment prioritized debulking surgery with paclitaxel-based chemotherapy. The harsh truth is that female patients are prone to relapse due to the dissemination of tumor cells and drug resistance. In these circumstances, the development of new therapy strategies combined with traditional approaches is conductive to improving the quality of treatment. Among numerous drug resources, botanical compounds have unique advantages due to their potentials in multitarget functions, long application history, and wide availability. Previous studies have revealed the therapeutic effects of bioactive plant components in ovarian cancer. These natural ingredients act as part of the initial treatment or an auxiliary option for maintenance therapy, further reducing the tumor and metastatic burden. In this review, we summarized the functions and mechanisms of natural botanical components applied in human ovarian cancer. We focused on the molecular mechanisms of cell apoptosis, autophagy, RNA and DNA lesion, ROS damage, and the multiple-drug resistance. We aim to provide a theoretical reference for in-depth drug research so as to manage ovarian cancer better in clinic.

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“…Zeylenone (Zey) is a natural cyclohexene oxide compound isolated from Uvaria grandiflora Roxb 6 . Since the discovery of Zey in 1997, researchers have carried out multiple studies on its manufacturing processes (synthesis/semi-synthesis), pharmacodynamics and molecular mechanism, etc, and it was considered to be an anti-tumor candidate drug with great potential [7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Zeylenone (Zey) is a natural cyclohexene oxide compound isolated from Uvaria grandiora Roxb. 6 Since the discovery of Zey in 1997, researchers have carried out multiple studies on its manufacturing processes (synthesis/semi-synthesis), pharmacodynamics, molecular mechanism, etc., and it was considered to be an anti-tumor drug candidate with great potential. [7][8][9][10] Studies have shown that Zey could induce signicant cell apoptosis through a mitochondrial apoptosis pathway and inhibit the invasion and migration of gastric cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Development of S4A–BSA–Au NPs for enhanced anti-tumor therapy of canine breast cancer

Chen

Sun

et al. 2022

Nanoscale Adv.

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Zeylenone inhibits proliferation and promotes apoptosis in ovarian carcinoma cells via Janus kinase 2 / signal transducers and activators of transcription 3 pathways

Abstract: Zeylenone inhibited cell proliferation and promoted apoptosis in ovarian carcinoma cells. The JAK-STAT pathway was involved in this progress.

Cited by 9 publications

References 18 publications

Establishment of patient‐derived xenograft model in ovarian cancer and its influence factors analysis

Establishment of patient‐derived xenograft model in ovarian cancer and its influence factors analysis

Mechanisms and Advances in Anti-Ovarian Cancer with Natural Plants Component

Development of S4A–BSA–Au NPs for enhanced anti-tumor therapy of canine breast cancer

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