Zerumbone, a major sesquiterpene from Syringa pinnatifolia Hemsl., exerts the sedative effect by regulating GABAergic nervous system

Wuken, Shana; Li, Junjun; Gao, Xiaoli; Jiao, Shungang; Ma, Xiaojing; Chen, Suyile; Tu, Pengfei; Huang, Luqi; Chai, Xingyun

doi:10.1016/j.jep.2022.115813

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Mice of gavage administration were randomly divided into 5 groups (n = 8): ESO-L (20 mg/kg), ESO-M (40 mg/kg), ESO-H (80 mg/kg), positive control diazepam (1.5 mg/kg), [3] and model (vehicle, water) group. Following that, mice were placed into a small animal autonomous activity recorder (Jinan Yiyan Science & Technology Development Co., Ltd., Shandong, China) 0.5 h after the administration.…”

Section: Locomotor Activity Testmentioning

confidence: 99%

“…According to the theory of Chinese medicine, the medicinal parts of SO include the leaves, buds, flowers, branches, and bark, which have been used to treat hepatitis, intestinal disorders, and diarrhea, whereas the heartwood of SO is used as an MFM for its efficacy of clearing heat and inhibiting the partial prosperity of "Khii" in the theory of traditional Mongolian medicine. [2] Since the partial prosperity of "Khii" is one of the basic pathological mechanisms resulting in heart diseases, insomnia, and pain in the theory of traditional Mongolian medicine, [3] SO is clinically used to treat pain, insomnia, fever, and cardiovascular diseases, and commonly used as a substitution to the peeled stems of Syringa pinnatifolia. [4] Contemporary studies have shown that SO as TCM has effects of anti-inflammation, antioxidation, antibiosis, and hepatoprotection, [5 -9] and contains iridoids, phenylpropanoids, triterpenoids, phenylethanes, and flavonoids.…”

Section: Introductionmentioning

confidence: 99%

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The Ethanol Extract of Syringa oblata Heartwood, a Mongolian Folk Medicine Containing Major Lignans, Exerts Analgesic and Sedative Effects on Mice

Chai

Tai

et al. 2022

Chemistry & Biodiversity

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The heartwood of Syringa oblata Lindl. (SO) is one of Mongolian folk medicines to treat insomnia and pain, while its pharmacological evaluation and underlying mechanism remain unclear. In this study, the sedative effect of ethanol extract of SO (ESO) was evaluated with the locomotor activity test and the threshold dose of pentobarbital sodium-induced sleep test in mice, and the hot plate test, acetic acid-induced writhing test, and formalin test in mice were used to evaluate its analgesic effect. The underlying mechanism of ESO analgesia was explored by RT-PCR and western blot analysis, which is associated with the regulation of the NF-кB signaling pathway. Besides, the main constituents of ESO were characterized by LC/MS data analysis and comparison with isolated pure compounds. The current findings brought evidence for clinical application and further pharmacological and phytochemical studies on SO.

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Section: Locomotor Activity Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Ethanol Extract of Syringa oblata Heartwood, a Mongolian Folk Medicine Containing Major Lignans, Exerts Analgesic and Sedative Effects on Mice

Chai

Tai

et al. 2022

Chemistry & Biodiversity

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Therapeutic potential of Rosa roxburghii folium extract in insomnia treatment: a comprehensive evaluation of behavioral and neurochemical effects in a PCPA‐induced mouse model

He,

Yan,

Peng

et al. 2024

J Sci Food Agric

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BACKGROUNDInsomnia, a prevalent sleep disorder, detrimentally affects quality of life and is often challenging to manage with conventional treatments. This study delved into identifying and quantifying the main compounds by employing ultra‐performance liquid chromatography–Q‐Exactive‐Orbitrap mass spectrometry, and further to evaluate the therapeutic potential of Rosa roxburghii folium (RRF) extract, with multiple pharmacological activities. Previous research had hinted at the efficacy of glycosides in influencing the γ‐aminobutyric acid (GABAergic) system, which plays a pivotal role in sleep regulation. Utilizing a p‐chlorophenylalanine‐induced insomnia model in BALB/C mice, this investigation aimed to unravel the effects of various dosages of RRF extract on sleep quality and elucidated its mechanism of action.RESULTSA total of 66 compounds in the RRF extract were analyzed. Behavioral assessments demonstrated notable enhancements in sleep duration and latency. Biochemical analyses further corroborated these findings, revealing modulation in neurotransmitter levels indicative of a potential mechanism through the GABAergic and serotoninergic pathways. Additionally, histological evaluations suggested anti‐inflammatory and antioxidant effects of the RRF extract.CONCLUSIONThe findings from this study underscored the therapeutic efficacy of RRF extract in combating insomnia, particularly highlighting its glycoside components’ role. The extract's significant improvement in sleep duration and latency, alongside its modulation of neurotransmitter levels, showcases its potential as a natural remedy for insomnia. Through its action on the GABAergic and serotoninergic pathways, as well as its anti‐inflammatory and antioxidant effects, RRF extract emerges as a promising candidate for insomnia treatment, offering a holistic approach to sleep disorder management. © 2024 Society of Chemical Industry.

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Sleep-improving effect and the potential mechanism of Morus alba L. on mice

Kong,

Zhou,

et al. 2024

Fitoterapia

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Zerumbone, a major sesquiterpene from Syringa pinnatifolia Hemsl., exerts the sedative effect by regulating GABAergic nervous system

Cited by 5 publications

References 24 publications

The Ethanol Extract of Syringa oblata Heartwood, a Mongolian Folk Medicine Containing Major Lignans, Exerts Analgesic and Sedative Effects on Mice

The Ethanol Extract of Syringa oblata Heartwood, a Mongolian Folk Medicine Containing Major Lignans, Exerts Analgesic and Sedative Effects on Mice

Therapeutic potential of Rosa roxburghii folium extract in insomnia treatment: a comprehensive evaluation of behavioral and neurochemical effects in a PCPA‐induced mouse model

Sleep-improving effect and the potential mechanism of Morus alba L. on mice

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