Zero in the brain: A voxel-based lesion–symptom mapping study in right hemisphere damaged patients

Benavides-Varela, Silvia; Passarini, Laura; Butterworth, Brian; Rolma, Giuseppe; Burgio, Francesca; Pitteri, Marco; Meneghello, Francesca; Shallice, Tim; Semenza, Carlo

doi:10.1016/j.cortex.2016.01.011

Cited by 23 publications

(21 citation statements)

References 69 publications

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“…The results of the voxel-based lesion symptom mapping analysis were in accordance with our assumptions and in line with the study by Benavides-Varela et al . 20 . The significant cluster was localised in the right putamen extending to the right insular cortex.…”

Section: Discussionmentioning

confidence: 99%

“…To explicitly address the necessary contributions of the right cerebral hemisphere to number transcoding processes, a recent study by Benavides-Varela et al . assessed 22 right-brain-damaged patients with two number transcoding tasks: reading Arabic numerals and writing to dictation in the Arabic code 20 . Voxel-based lesion symptom mapping (VLSM) was used to identify brain regions that were significantly associated with committing zero errors in transcoding.…”

Section: Introductionmentioning

confidence: 99%

“…The VLSM results demonstrated that patients committing overwriting errors had lesions associated with the right insula as well as parts of the frontal inferior and Rolandic operculum extending posteriorly towards the superior temporal gyrus. Furthermore, the right hemisphere was also prominently associated with other error types involving the addition and omission of zeros 20 .…”

Section: Introductionmentioning

confidence: 99%

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The zero effect: voxel-based lesion symptom mapping of number transcoding errors following stroke

Haupt

Gillebert

Demeyere

2017

Sci Rep

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Zero represents a special case in our numerical system because it is not represented on a semantic level. Former research has shown that this can lead to specific impairments when transcoding numerals from dictation to written digits. Even though, number processing is considered to be dominated by the left hemisphere, studies have indicated that both left as well as right hemispheric stroke patients commit errors when transcoding numerals including zeros. Here, for the first time, a large sample of subacute stroke patients (N = 667) was assessed without being preselected based on the location of their lesion, or a specific impairment in transcoding zero. The results show that specific errors in transcoding zeros were common (prevalence = 14.2%) and a voxel-based lesion symptom mapping analysis (n = 153) revealed these to be related to lesions in and around the right putamen. In line with former research, the present study argues that the widespread brain network for number processing also includes subcortical regions, like the putamen with connections to the insular cortex. These play a crucial role in auditory perception as well as attention. If these areas are lesioned, number processing tasks with higher attentional and working memory loads, like transcoding zeros, can be impaired.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The zero effect: voxel-based lesion symptom mapping of number transcoding errors following stroke

Haupt

Gillebert

Demeyere

2017

Sci Rep

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“…B 373: 20170044 transcoding numbers without zeros. Such mechanisms for dealing with zero in complex numbers may require, according to Benavides-Varela et al [52], setting-up appropriate empty-slot structures and parsing and mastering of categorical spatial relations between digits. The lesion study suggested a specific location of these mechanisms in the right insula and immediate surroundings.…”

Section: (Iii) the Influence Of Neglectmentioning

confidence: 99%

Reassessing lateralization in calculation

Semenza

Benavides-Varela

2018

Phil. Trans. R. Soc. B

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The role of the left hemisphere in calculation has been unequivocally demonstrated in numerous studies in the last decades. The right hemisphere, on the other hand, had been traditionally considered subsidiary to the left hemisphere functions, although its role was less clearly defined. Recent clinical studies as well as investigations conducted with other methodologies (e.g. neuroimaging, transcranial magnetic stimulation and direct cortical electro-stimulation) leave several unanswered questions about the contribution of the right hemisphere in calculation. In particular, novel clinical studies show that right hemisphere acalculia encompasses a wide variety of symptoms, affecting even simple calculation, which cannot be easily attributed to spatial disorders or to a generic difficulty effect as previously believed. The studies reported here also show how the right hemisphere has its own specific role and that only a bilateral orchestration between the respective functions of each hemisphere guarantees, in fact, precise calculation. Vis-à-vis these data, the traditional wisdom that attributes to the right hemisphere a role mostly confined to spatial aspects of calculation needs to be significantly reshaped. The question for the future is whether it is possible to precisely define the specific contribution of the right hemisphere in several aspects of calculation while highlighting the nature of the cross-talk between the two hemispheres.This article is part of a discussion meeting issue 'The origins of numerical abilities'.

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“…Recently, a study by De Clercq-Quaegebeur et al (2018) observed that children with dyslexia have mathematical-related deficits, including number transcoding. Other authors have reported case studies of transcoding deficits in patients with brain injury or degenerative diseases (Benavides-Varela et al, 2016;Cipolotti, Warrington, & Butterworth, 1995;Dotan & Friedmann, 2018).…”

Section: Palavras-chave: Habilidades Numéricas Básicas; Dislexia; Matmentioning

confidence: 99%

Arabic number writing in children with developmental dyslexia

Teixeira

Moura

2020

Estud. psicol. (Campinas)

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Number transcoding is a basic numerical processing task that demands verbal skills during its execution. The goal of this study was to investigate number transcoding ability in children with developmental dyslexia. Twenty-three children with typical development and twenty-six children with developmental dyslexia participated in this study. Results showed that children with dyslexia show a deficit in phonological processing as well as in number transcoding. Repeated-measures analysis of covariance indicated that the dyslexia group presented performance below the average in the number transcoding. Regression analyses indicated that short-term verbal memory, phoneme deletion, rhyme judgment task and automatized naming was a strong predictor of number transcoding difficulties. Children with dyslexia present number transcoding deficits regardless of age and educational level.

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Zero in the brain: A voxel-based lesion–symptom mapping study in right hemisphere damaged patients

Cited by 23 publications

References 69 publications

The zero effect: voxel-based lesion symptom mapping of number transcoding errors following stroke

The zero effect: voxel-based lesion symptom mapping of number transcoding errors following stroke

Reassessing lateralization in calculation

Arabic number writing in children with developmental dyslexia

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