Zero-Field Magnetometry Based on Nitrogen-Vacancy Ensembles in Diamond

Zheng, Huijie; Xu, Jingyan; Iwata, Geoffrey Z.; Lenz, Till; Michl, Julia; Yavkin, Boris; Nakamura, Kazuo; Sumiya, Hitoshi; Ohshima, Takeshi; Isoya, Junichi; Wrachtrup, Jörg; Wickenbrock, Arne; Budker, Dmitry

doi:10.1103/physrevapplied.11.064068

Cited by 85 publications

(54 citation statements)

References 29 publications

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“…In this arrangement, an externally hyperpolarized probe can be intravenously injected into a patient and NMR signals can be detected via an array of magnetometers in a manner similar to one recently demonstrated for brain magnetoencephalography 58 . In addition to atomic magnetometers, sensors based to the nitrogen-vacancy (NV) color centers in diamond can be used, whose operation at zero field (relevant for ZULF NMR) was recently demonstrated 59 .…”

Section: Resultsmentioning

confidence: 99%

Zero-Field Nuclear Magnetic Resonance of Chemically Exchanging Systems

Barskiy

Tayler²,

Marco‐Rius³

et al. 2019

Preprint

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Zero- and ultralow-field (ZULF) nuclear magnetic resonance (NMR) is an emerging tool for precision chemical analysis. Unlike conventional (high-field) NMR, which relies on chemical shifts for molecular identification, zero-field analog reports J-spectra that depend on the nuclear spin-spin coupling topology of molecules under investigation. While chemical shifts are usually a small fraction of the resonance frequencies, J-spectra for various spin systems are completely different from each other. In this work, we use zero-field NMR to study dynamic chemical processes and investigate the influence of chemical exchange on ZULF NMR spectra. We develop a computation approach that allows quantitative calculation of ZULF NMR spectra in the presence of chemical exchange and apply it to study aqueous solutions of [15N]ammonium as a model system. In this system, proton exchange rates span more than three orders of magnitude depending on acidity (pH), as monitored by high-field and ZULF NMR. We show that chemical exchange substantially affects the J-coupled NMR spectra and, in some cases, can lead to degradation and complete disappearance of the spectral features. To demonstrate potential applications of ZULF NMR for chemistry and biomedicine, we show a ZULF NMR spectrum of [2-13C]pyruvic acid hyperpolarized via dissolution dynamic nuclear polarization (dDNP). The metabolism of pyruvate provides valuable biochemical information and its monitoring by zero-field NMR could give spectral resolution that is hard to achieve at high magnetic fields. We foresee applications of affordable and scalable ZULF NMR coupled with hyperpolarization modalities to study chemical exchange phenomena in vivo and in situations where high-field NMR detection is not possible to implement.

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Section: Resultsmentioning

confidence: 99%

Zero-Field Nuclear Magnetic Resonance of Chemically Exchanging Systems

Barskiy

Tayler²,

Marco‐Rius³

et al. 2019

Preprint

Self Cite

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“…These frequencies are however too high for detection of many biological signals in the sub-kHz range. The best reported low frequency/DC sensitivities are typically worse [15][16][17] with few-nT/ √ Hz. Vector magnetometry has also been demonstrated in the DC-low frequency range, important since magnetic fields from complex biosystems may not be easily directed along a single sensitive NV axis [18,19].…”

Section: Introductionmentioning

confidence: 99%

Optimization of a Diamond Nitrogen Vacancy Centre Magnetometer for Sensing of Biological Signals

Webb

Troise

Hansen³

et al. 2020

Front. Phys.

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“…Furthermore, usage of oriented NV samples are particularly beneficial for zero-field applications which extend the dynamic range of the magnetometer. [16,17] Compared to the lowenergy ion implantation technique, nitrogen incorporation (e.g., N doping) during diamond growth avoids the collateral damage of the crystal lattice, thus improving the spin environment of individual NV centers. Although some demonstration of enhanced magnetometry with preferentially aligned ensembles has been achieved, [18,19] the coherence time and the ensembles' density remain as critical limitations toward realistic applications.…”

mentioning

confidence: 99%

Benchmark for Synthesized Diamond Sensors Based on Isotopically Engineered Nitrogen‐Vacancy Spin Ensembles for Magnetometry Applications

et al. 2020

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Nitrogen‐vacancy (NV) center ensemble in synthetic diamond is a promising and emerging platform for quantum sensing technologies. Realization of such a solid‐state based quantum sensor is widely studied and requires reproducible manufacturing of NV centers with controlled spin properties, including the spin bath environment within the diamond crystal. Here, a non‐invasive method is reported to benchmark NV ensembles regarding their suitability as ultra‐sensitive magnetic field sensors. Imaging and electron spin resonance techniques are presented to determine operating figures and precisely define the optimal material for NV‐driven diamond engineering. The functionality of the methods is manifested on examples of chemical vapor deposition synthesized diamond layers containing preferentially aligned, isotopically controlled 15NV center ensembles. Quantification of the limiting 15N P1 spin bath, in an otherwise 12C enriched environment, and the reduction of its influence by applying dynamical decoupling protocols, complete the suggested set of criteria for the analysis of NV ensemble with potential use as magnetometers.

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Zero-Field Magnetometry Based on Nitrogen-Vacancy Ensembles in Diamond

Cited by 85 publications

References 29 publications

Zero-Field Nuclear Magnetic Resonance of Chemically Exchanging Systems

Zero-Field Nuclear Magnetic Resonance of Chemically Exchanging Systems

Optimization of a Diamond Nitrogen Vacancy Centre Magnetometer for Sensing of Biological Signals

Benchmark for Synthesized Diamond Sensors Based on Isotopically Engineered Nitrogen‐Vacancy Spin Ensembles for Magnetometry Applications

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