Zero-dimensional carbon nanomaterials for tissue engineering applications

Vats, Monika; Swami, Mansi; Dwivedi, Awadesh Kumar; Rajendra, Kushagra

doi:10.1088/978-0-7503-4048-9ch11

Cited by 2 publications

(3 citation statements)

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“…Carbon dots have been reported to affect the differentiation of stem cells through cellular internalization, and their superior photophysical properties can be combined with photodynamic therapy to achieve broad‐spectrum antimicrobial capacity. [ 13 ] Therefore, carbon dots are a more promising 0D biomaterial for amplifying biological signals. However, the excitation of light utilized in traditional photodynamic therapy sparks the creation of ROS in a specific area, and harmful waste products ensuing from bacterial degradation can result in the loss of other resident cells, thus jeopardizing the upkeep of the ecological niche's stability.…”

Section: Introductionmentioning

confidence: 99%

0D Amplification Strategies Reshape Bone Interface Niches via Biointernalization Effects

Yu,

Wang,

Sun

et al. 2024

Adv Funct Materials

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Abstract0D biomaterials (0DBMs) can serve as carriers to enhance and extend the regulatory effects of biological cues they transport on cell fate via bacterial/mammalian cell internalization. However, accurately delivering and amplifying biosignals through 0DBMs remains challenging to cope with ecological niche destabilization induced by factors such as trauma or infection. Herein, the “zero‐dimensional amplification” approach is employed to develop a surface carboxylate carbon dot (CQD‐COOH) conjugated with a neutrophil constitutive peptide (LL‐37), resulting in the formation of a 0D peptide quantum dot (LQD). Hydrogel‐released LQDs, when internalized by bacteria, cause the bacteria to programmatically rupture and die, whereas LQDs internalized by mesenchymal stem cells (MSCs) activate the cellular CXCL12/CXCR4 signaling axis, which directs the stem cells to homing and anchor to the surface of the hydrogel coating. Notably, this strategy of “zero‐dimensional amplification” enables the antimicrobial performance of LL‐37 to be boosted approximately 1.3‐fold, significantly extending the transmission efficiency of biosignals. Meanwhile, 0D lipid nanoparticles (lipo‐NPs) with targeting function incorporated into the hydrogel could deliver the bio‐small molecule MK‐4 to MCSs and induce their endocytosis, further enhancing osseointegration. Thus, the hydrogel coating (HGLL) under this strategy can significantly remodel the ecological niche of the implant–bone interface in infected environment.

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Section: Introductionmentioning

confidence: 99%

0D Amplification Strategies Reshape Bone Interface Niches via Biointernalization Effects

Yu,

Wang,

Sun

et al. 2024

Adv Funct Materials

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“…Traditional carbon‐based materials such as carbon black, activated carbon, and also some advanced carbon‐based materials like graphite, graphene, and carbon nanotubes are widely used in basic research and applications in various fields of electronics, optics, sensors, medicine, and many more 1–3 . Among all the carbon‐based materials in the carbon family, carbon dots (CDs) discovered in 2004 4 are the new rising star with a unique quantum size effect of zero‐dimensional nanoparticles smaller than 10 nm 5,6 . CDs are widely used as functional fillers in various substrate materials 7 .…”

Section: Introductionmentioning

confidence: 99%

“…nanoparticles smaller than 10 nm. 5,6 CDs are widely used as functional fillers in various substrate materials. 7 CDs also exhibit excellent size-dependent optical, electronics, and electrochemical properties.…”

mentioning

confidence: 99%

Functional and ultrastretchable thermoplastic elastomeric materials: Influence of carbon dots on fluorescence, dielectric and mechanical properties

Shrikhande,

Rana,

Molla

et al. 2024

J of Applied Polymer Sci

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Carbon dots (CDs) are an interesting nanomaterial due to their tunable photoluminescence and other functional properties. Herein, by introducing amine‐functionalized CDs nanoparticles onto macromolecular chains of maleic anhydride grafted styrene‐ethylene‐butylene‐styrene (SEBS‐g‐MA) via a possible ring‐opening reaction of anhydride with amine, a mechanically robust and ultrastretchable thermoplastic elastomeric materials with fluorescence and dielectric functionality was developed. The amine‐functionalized CDs nanoparticles were synthesized from pyrene precursor by hydrothermal treatment. The transmission electron micrograph, Raman, Fourier transform infrared, and x‐ray photoelectron spectra confirmed the formation of highly crystalline graphitized structure of the CDs nanoparticles. Fluorescence and UV–Vis spectroscopy were used to evaluate the optical properties of the developed materials. The developed CDs/SEBS‐g‐MA nanocomposites exhibited strong intense green fluorescence compared with the pure SEBS‐g‐MA film. The thermal stability of the developed nanocomposites was improved by an increase of the Tmax by about 18°C. In addition, the developed composite showed high stretchability (strain at break ~1000%), good mechanical strength, and dielectric properties (room temperature dielectric constant ~5.2). The enhanced dielectric property of the developed composites may be due to the space charge accumulation and induced interfacial polarization at the filler–matrix interface.

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Zero-dimensional carbon nanomaterials for tissue engineering applications

Cited by 2 publications

References 0 publications

0D Amplification Strategies Reshape Bone Interface Niches via Biointernalization Effects

0D Amplification Strategies Reshape Bone Interface Niches via Biointernalization Effects

Functional and ultrastretchable thermoplastic elastomeric materials: Influence of carbon dots on fluorescence, dielectric and mechanical properties

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