Zerebrovaskuläre Erkrankungen

Hagen, Thomas; Bartylla, K.; Piepgras, U

doi:10.1007/bf03044144

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…Another study [ 15 ] involved detailed studies in configurations and hemodynamics of CoWs of six pairs of MTs while not associated with CAs. Other studies focused more on reporting CA discoveries in MTs based on scanned digital subtraction angiography (DSA) images [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ] rather than investigating specific hemodynamic factors resulting in CAs in the corresponding arteries and CAs. Thus, to facilitate the understanding of morphology and hemodynamics in CAs involved in the MTs, and to enrich the case studies in the CA research community, a careful study on the pathophysiology of CAs in MT models is extremely valuable.…”

Section: Introductionmentioning

confidence: 99%

Morphology and Hemodynamics of Cerebral Arteries and Aneurysms in a Rare Pair of Monozygotic Twins

Yang

Bramlage

et al. 2023

Diagnostics

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In this preliminary study, the underlying pathophysiology mechanisms of cerebral aneurysms (CAs) in monozygotic twins (MTs) were investigated via a rare pair of MTs (twin A and twin B) involving four reconstructed arterial models using preclinical information. First, dimensions and configurated outlines of three-perspective geometries were compared. Adopting an in-vitro validated numerical CA model, hemodynamic characteristics were investigated in the MTs, respectively. Despite expected genetic similarities, morphological comparisons show that configurations of cerebral arteries exhibit significant differences between the twins. The ICA size of twin A is larger than that in twin B (2.23~25.86%), varying with specific locations, attributing to variations during embryological developments and environmental influences. Numerical modeling indicates the MTs have some hemodynamic similarities such as pressure distributions (~13,400 Pa) and their oscillatory shear index (OSI) (0~0.49), but present significant differences in local regions. Specifically, the difference in blood flow rate in the MTs is from 16% to 221%, varying with specifically compared arteries. The maximum time-averaged wall shear stress (53.6 Pa vs. 37.8 Pa) and different local OSI distributions were also observed between the MTs. The findings revealed that morphological variations in MTs could be generated by embryological and environmental factors, further influencing hemodynamic characteristics on CA pathophysiology.

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Section: Introductionmentioning

confidence: 99%

Morphology and Hemodynamics of Cerebral Arteries and Aneurysms in a Rare Pair of Monozygotic Twins

Yang

Bramlage

et al. 2023

Diagnostics

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Alterations in diffusion and perfusion in the pathogenesis of peritumoral brain edema in meningiomas

Bitzer

Klose

et al. 2002

Eur Radiol

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Magnetic resonance perfusion and diffusion studies were undertaken to clarify the significance of ischemia in the pathogenesis of peritumoral brain edema in patients with meningiomas. Included in this study were 26 patients with 27 meningiomas and 5 gliomas. Perfusion-weighted imaging (PWI) was performed using a gradient-echo, echo-planar-imaging (EPI) sequence for calculation of the relative regional cerebral blood volume (rrCBV) and the relative regional cerebral blood flow index (rrCBFi). Furthermore, multi-slice spin-echo EPI sequences were applied in order to obtain anisotropic and isotropic diffusion-weighted imaging (DWI). Apparent diffusion coefficient (ADC) values were then calculated for peritumoral brain parenchyma from tumors, with and without edema, using various diffusion sensitivities. Meningiomas without edema demonstrated a minimal increase of perfusion parameters in the peritumoral brain tissue. In contrast, cases with brain edema had highly significant ( p<0.0005) lower rrCBV and rrCBFi. The edema index (EI) correlated strongly with the rrCBV. A fitting procedure resulted into the following mathematical relation: EI=0.1/rrCBV(2). The DWI showed a significantly larger ADC value within areas of brain edema, compared with the normal white matter (0.74 x 10(-3) vs 1.55 x 10(-3) mm(2)/s; p<0.0001). Increases in EI correlated with increases in ADC values. In 31% of the meningiomas associated with edema, areas with increased signal, probable ischemia, demonstrated significantly lower ADC values, in comparison with the rest of the edematous areas. These areas were confined to tissue immediately adjacent to the tumor. In general, the decrease in rrCBV in brain edema represents a consequence from, rather than a cause of, vasogenic edema. Ischemic alterations can be regarded as secondary, facultative phenomena in the pathogenesis of meningioma-related brain edema.

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Changes of cerebral perfusion after osmotherapy in acute cerebral edema assessed with perfusion weighted MRI

Stoll

Hagen

Bartylla

et al. 1998

Neurological Research

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Zerebrovaskuläre Erkrankungen

Cited by 4 publications

References 19 publications

Morphology and Hemodynamics of Cerebral Arteries and Aneurysms in a Rare Pair of Monozygotic Twins

Morphology and Hemodynamics of Cerebral Arteries and Aneurysms in a Rare Pair of Monozygotic Twins

Alterations in diffusion and perfusion in the pathogenesis of peritumoral brain edema in meningiomas

Changes of cerebral perfusion after osmotherapy in acute cerebral edema assessed with perfusion weighted MRI

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