Zerebrale Vaskulitis als Erstmanifestation 
eines systemischen Lupus erythematodes

Je, Wolf; Niedermaier, Nikolaj; Bergner, Raoul; Lowitzsch, К.

doi:10.1055/s-2001-16581

Cited by 5 publications

(3 citation statements)

References 1 publication

(1 reference statement)

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“…CNS involvement in SLE is a major cause of morbidity and mortality. Neuropathological studies of SLE are very few due to improved prognosis 1,2,4–10 . Most common neuropathological finding in various studies is multifocal infarcts 1,2 .…”

Section: Discussionmentioning

confidence: 99%

Active necrotizing cerebral vasculitis in systemic lupus erythematosus

Goel¹,

Reddy²,

Challa³

et al. 2007

Neuropathology

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Systemic lupus erythematosus (SLE) is a multisystemic disease with varied clinical manifestations. Focal cortical brain infarcts and CNS infections are the most common neuropathological features reported in most studies. This report describes a 32-year-old woman who had repeated episodes of strokes over 5 years. In view of polyarthritis, oral ulcers, presence of high titres of serum antinuclear antibodies, high titres of double-stranded DNA and strokes, she was treated as SLE. Despite prolonged immunosuppressive therapy with azathioprine and pulse cyclophosphamide, she succumbed to a brainstem stroke. Complete body autopsy showed multiple cerebral cortical and brainstem infarcts with fibrinoid necrosis of the vessel wall. Renal infarction with healed vasculitis and systemic vasculitis involving small vessels was seen. Extensive thrombosis was remarkable by its absence. Active necrotizing vasculitis of cerebral and renal vessels is a rare complication of SLE, which contributed to a fatal outcome in this patient.

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Section: Discussionmentioning

confidence: 99%

Active necrotizing cerebral vasculitis in systemic lupus erythematosus

Goel¹,

Reddy²,

Challa³

et al. 2007

Neuropathology

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“…Central nervous system involvement is reported in some cases, including seizures, psychosis, organic brain syndrome, aseptic meningitis and cognitive dysfunction. [2][3][4][5][6][7][8] A review of the literature was performed, and the presenting neurological features and therapies are summarized in Table 1.…”

Section: Partial Epilepsy As An Initial Manifestation In Bullous Systemic Lupus Erythematosusmentioning

confidence: 99%

Partial epilepsy as an initial manifestation in bullous systemic lupus erythematosus

Pan

Tang

Zhu

et al. 2011

Lupus

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“…Its diagnosis requires the presence of an acquired neurological deficit, classic angiographic evidence consistent with vasculitis or histopathological demonstration of angiitis within the central nervous system (CNS), and no evidence of systemic vasculitis or another autoimmune, infectious or malignant process. 1 Antiphospholipid syndrome (APS) involves recurrent arterial or venous thrombosis, pregnancy loss, and repeated detection of anticardiolipin antibodies or lupus anticoagulant at least 6 weeks apart. 2 APS may result in neurological complications such as stroke, migraine, chorea, seizures or transverse myelitis.…”

mentioning

confidence: 99%