Zelluläre Wirkungen von Somatostatin und Pirenzipin im Antrum der Ratte

Inhibitory Effect of Prolonged Administration of Long-Acting Somatostatin on Gastrin-Stimulated Fundic Epithelial Cell Growth in the Rat

“…In adult mice, 8 pg of somatostatin, administered for 12 days, resulted in a dim inution in parietal cell density and paradoxi cally in an increase in peptic cell densityboth parameters being estimated on one strip per stomach excised at the same location [20], This dose roughly corresponds to that injected in our young rats. Finally, in rats receiving a notably smaller dose (3.8 pg/day for 20 days), a significant decrease in gastric DNA content was found [7], It has recently been shown that, in another tissue, namely bone tissue, somatostatin can locally regulate the proliferation and differentiation of chondro-and osteoprogenitor cells in vivo [22], We can, therefore, speculate that in this case this inhibitory action of somatostatin might be independent of its inhibitory action on gastrin release.…”