Zein/luteolin microparticles formation using a supercritical fluids assisted technique

Antioxidants entrapment in polycaprolactone microparticles using supercritical assisted injection in a liquid antisolvent

“…Test ALA_04 carried out at 40 °C, shows that all the ALA contained in the microparticles is released in a concentration lower than the test carried out at 60 °C (ALA_01). Furthermore, it should be noted that, when saturator temperature increases, the initial burst in the release is more pronounced; indeed, over 40 % of the drug is released after just 2 h. This trend could be due to the drug presence on the microparticles surface in the case of particles produced at 60 °C and could confirm the hypothesis of the competition of the drug diffusive phenomenon with respect to precipitation in the antisolvent at a higher temperature, as illustrated in a previous coprecipitation study ( Palazzo et al, 2019 ).…”

“…The reasons that make this process advantageous in the production of coprecipitates are related to the possibility of using nontoxic solvents (for example acetone and ethanol), reaching submicronic and nanometric dimensions and producing micro and nanocomposites directly in stable suspensions, with a continuous process in which the particles are obtained in a single step. This process was successfully used to micronize and coprecipitate polymers and pharmaceutical compounds with the production of polymer/drug suspensions ( Palazzo et al, 2019 ; Trucillo and Campardelli, 2019 ). In particular, SAILA process gave interesting results in the micronization of polycaprolactone (PCL) used as model polymer: particles of about 64 nm, spherical-shaped, monodisperse and non-aggregated were produced ( Campardelli et al, 2012 ).…”

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation

“…Using a process, named supercritical assisted injection in a liquid antisolvent (SAILA), luteolin was entrapped in zein microparticles. This system showed faster dissolution rate with a consequent increase in bioavailability while preserving the antioxidant activity of luteolin [646].…”

Nanoparticles and Nanocrystals by Supercritical CO2-Assisted Techniques for Pharmaceutical Applications: A Review

“…In this process, carbon dioxide has the role of a co-solute, whereas water has the role of the antisolvent. SAILA technique has been successfully applied for the micro/nanonization of pure compounds [148][149][150][151][152] or for the attainment of polymer/drug coprecipitates [146,153,154]. The organic solvents commonly used for this process are acetone and ethanol; however, in some cases, isopropanol has also been used.…”