Zein/gum Arabic nanoparticle-stabilized Pickering emulsion with thymol as an antibacterial delivery system

Li, Juan; Xu, Xueer; Chen, Zhengxing; Wang, Tao; Lu, Zhe‐Ming; Hu, Weicheng; Wang, Li

doi:10.1016/j.carbpol.2018.08.025

Cited by 137 publications

(47 citation statements)

References 48 publications

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“…This observation is consistent with the decreased total amount of nanoparticles available to be adsorbed at the oil/water interface, which results in the formation of droplets of larger size. These results are in agreement with the findings reported in previous studies (Atarian et al, 2019;Li et al, 2018). Moreover, when the oil volume fraction increased above 0.7 (φ = 0.8), oiling off and droplet flocculation were noticed, and the droplets started to deform by losing their spherical shape; indicating that the number of the available nanoparticles was not enough to stabilize the Pickering droplets against coalescence.…”

Section: Effect Of the Oil Volume Fraction On Morphology And Stabilitysupporting

confidence: 92%

“…Moreover, when the oil volume fraction increased above 0.7 (φ = 0.8), oiling off and droplet flocculation were noticed, and the droplets started to deform by losing their spherical shape; indicating that the number of the available nanoparticles was not enough to stabilize the Pickering droplets against coalescence. A similar observation was noticed in zein/gum Arabic Pickering emulsions with an oil fraction above 0.6 (Li et al, 2018). For this reason, this sample (φ = 0.8) was discharged from subsequent characterizations.…”

Section: Effect Of the Oil Volume Fraction On Morphology And Stabilitysupporting

confidence: 77%

“…The creaming index (CI%) determination was used as an indicator for the stability of the emulsions against separation. It was calculated according to the following equation (Li et al, 2018;Mwangi et al, 2016):…”

Section: Creaming Indexmentioning

confidence: 99%

“…The use of gum Arabic in the formulation of Pickering emulsions has been reported, recently, in very few studies, with focus mainly on food applications. In this context, (Dai, Sun, Wei, Mao, & Gao, 2018) and (Li et al, 2018) produced Pickering emulsions stabilized by gum Arabic/zein protein particles. The particles were formed through electrostatic attraction between the two oppositely charged polymers and hydrogen bonding between them.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of chitosan/gum Arabic nanoparticles and their use as novel stabilizers in oil/water Pickering emulsions

Sharkawy

Barreiro

Rodrigues

2019

Carbohydrate Polymers

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A B S T R A C TRecently, there has been a renewed interest in Pickering emulsions owing to their surfactant-free nature, and the use of natural-based particles as stabilizers became a priority due to the applications they can enable. In this work, chitosan/gum Arabic (CH/GA) nanoparticles were synthesized and tested as novel stabilizers. Among the tested CH/GA weight ratios, the particles prepared using 1:1 ratio exhibited near-neutral wettability, an average size of 108.6 nm and a zeta potential of 56.3 mv. Pickering emulsions prepared from these particle dispersions (1.5% w/v), and high oil volume fractions (φ = 0.6, 0.7), have shown high storage stability. Moreover, confocal laser scanning microscopy confirmed the o/w type and the effective adsorption of the nanoparticles at the oil/ water interface forming a barrier against droplets coalescence. The emulsions have shown shear-thinning and elastic-like behavior. These findings open new avenues for using these emulsions as novel delivery systems, e.g. in cosmetic and food applications.

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Section: Effect Of the Oil Volume Fraction On Morphology And Stabilitysupporting

confidence: 92%

Section: Effect Of the Oil Volume Fraction On Morphology And Stabilitysupporting

confidence: 77%

Section: Creaming Indexmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation of chitosan/gum Arabic nanoparticles and their use as novel stabilizers in oil/water Pickering emulsions

Sharkawy

Barreiro

Rodrigues

2019

Carbohydrate Polymers

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“…Li et al, for example, have developed Pickering emulsions using combinations of corn prolamine zein and polysaccharide gum Arabic to encapsulate thymol, a natural anti-microbial agent. [111] This approach may overcome issues associated with poor biocompatibility of stabilising particles, and biodegradation may potentially facilitate sustained cargo release.…”

Section: Discussionmentioning

confidence: 99%

Recent developments in Pickering emulsions for biomedical applications

Harman

Patel

Guldin

et al. 2019

Current Opinion in Colloid & Interface Science

118

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Pickering emulsions, stabilised by organic or inorganic particles, offer long-term dispersibility of liquid droplets and resistance to coalescence. The versatility of stabilising particles and their ability to encapsulate and release cargo with high internal payload capacity makes them attractive in a wide variety of applications, ranging from catalysis to the cosmetic and food industry. While these properties make them an equally promising material platform for pharmaceutical and clinical applications, the development of Pickering emulsions for healthcare is still in its infancy. Herein, we summarise and discuss recent progress in the development of Pickering emulsions for biomedical applications, probing their design for passive diffusion-based release as well as stimuli-responsive destabilisation. We further comment on challenges and future directions of this exciting and rapidly expanding area of research.Pickering emulsions have been applied in a number of areas of research and industrial importance, such as food manufacturing, cosmetics, agrochemicals and therapeutic delivery. Their popularity in biomedical applications (i.e. for use in healthcare, such as therapeutics, diagnostics or imaging), in particular, has increased dramatically in recent years, thanks to their high stability, capacity for superior cargo loading compared to conventional systems, and diverse range of stabilising particles, creating a broad library of available building blocks. For biomedical and pharmaceutical application, the choice of emulsifier is critical; it must be biocompatible, non-toxic, and be able to be excreted from the body (if necessary). In this article, we will review the latest developments in the design and application of Pickering emulsions for biomedicine, with a focus on stimuli-responsive Pickering emulsions as a route to the triggered release of a payload towards advanced therapeutic delivery strategies. Within this discussion, we will describe systems which have been applied in proof of concept and in vitro assessments and emphasise areas of potential future development.

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Emulsion and its application in the food field: An update review

Wang

et al. 2023

eFood

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Natural emulsifier‐stabilized emulsions have garnered a significant amount of attention in many industries including foods, pharmaceuticals, cosmetics, health care formulations, paints, polymer blends and oils. Various methods have been used to improve the bioavailability of functional substances, such as microemulsions, nanoemulsions, Pickering emulsions, and complexes. Over recent years, emulsions have been increasingly investigated due to their potential as drug‐delivery vehicles for a wide range of application. In this review, we discuss some recent publications in the area of various emulsions in the food filed, detailed analysis of the mechanisms for different methods of preparation, compared with the different composition conditions on the stability. In addition, the above conditions affect the properties of the emulsions, but also affect functional activity. According to the current research status, some suggestions are put forward for further study.

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Zein/gum Arabic nanoparticle-stabilized Pickering emulsion with thymol as an antibacterial delivery system

Cited by 137 publications

References 48 publications

Preparation of chitosan/gum Arabic nanoparticles and their use as novel stabilizers in oil/water Pickering emulsions

Preparation of chitosan/gum Arabic nanoparticles and their use as novel stabilizers in oil/water Pickering emulsions

Recent developments in Pickering emulsions for biomedical applications

Emulsion and its application in the food field: An update review

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