Zein/Bioactive Glass Coatings with Controlled Degradation of Magnesium under Physiological Conditions: Designed for Orthopedic Implants

Rehman, Muhammad Atiq Ur

doi:10.3390/prosthesis2030018

Cited by 19 publications

(10 citation statements)

References 37 publications

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“…Furthermore, the signal intensity of Ca and P showed a strong increase with the increase in the incubation period. Thus, the SEM/EDX results indicated that a new phase with the chemical composition similar to HA developed on the surface of the multi‐structured coatings 40,41 . The HA is developed on the coatings owe to the heterogeneous nucleation.…”

Section: Resultsmentioning

confidence: 91%

Chitosan/gelatin‐based bioactive and antibacterial coatings deposited via electrophoretic deposition

Nawaz

Rehman

2020

J of Applied Polymer Sci

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The fabrication of biocompatible and antibacterial coatings on metallic implants remains a significant challenge for load‐bearing orthopedic implants. This study focuses on the electrophoretic deposition of chitosan/gelatin/Ag‐Mn doped mesoporous bioactive glass nanoparticles (Ag‐Mn MBGNs) composite on the PEEK/bioactive glass layer (called as multi‐structured coatings), which had been deposited electrophoretically on 316L stainless steel. The EPD parameters for the deposition of the chitosan/gelatin/Ag‐Mn MBGNs coatings were optimized via Taguchi design of experiment approach. Scanning electron microscopy images confirmed that the chitosan/gelatin/Ag‐Mn MBGNS layer was deposited on the PEEK/BG layer. The addition of biologically active metallic ions (Mn and Ag) and molecules (chitosan) showed a strong effect on the growth of bacteria. Moreover, the inclusion of Mn and Ag showed a negligible toxic effect on the bioactivity (the ability of the coating to form a bond with the natural bone) of the coatings. Furthermore, the multi‐structured coatings presented appropriate wettability and surface roughness for orthopedic applications. Overall, this study provides a direct solution to improve the bioactivity, antibacterial activity, and surface properties of deposited chitosan/gelatin coatings on orthopedic implants that are more manufacturable and translational from research to an industrial scale.

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Section: Resultsmentioning

confidence: 91%

Chitosan/gelatin‐based bioactive and antibacterial coatings deposited via electrophoretic deposition

Nawaz

Rehman

2020

J of Applied Polymer Sci

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“…The pH here increases due to the presence of OH − ions. Overall, positively charged zein/Ag-Sr doped MBGNs get attracted towards the cathode, and, along with the OH − ions, become unstable and get deposited on the cathode [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications

et al. 2022

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Implants are used to replace damaged biological structures in human body. Although stainless steel (SS) is a well-known implant material, corrosion of SS implants leads to the release of toxic metallic ions, which produce harmful effects in human body. To prevent material degradation and its harmful repercussions, these implanted materials are subjected to biocompatible coatings. Polymeric coatings play a vital role in enhancing the mechanical and biological integrity of the implanted devices. Zein is a natural protein extracted from corn and is known to have good biocompatibility and biodegradability. In this study, zein/Ag-Sr doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were deposited on SS substrates via electrophoretic deposition (EPD) at different parameters. Ag and Sr ions were added to impart antibacterial and osteogenic properties to the coatings, respectively. In order to examine the surface morphology of coatings, optical microscopy and scanning electron microscopy (SEM) were performed. To analyze mechanical strength, a pencil scratch test, bend test, and corrosion and wear tests were conducted on zein/Ag-Sr doped MBGN coatings. The results show good adhesion strength, wettability, corrosion, and wear resistance for zein/Ag-Sr doped MBGN coatings as compared to bare SS substrate. Thus, good mechanical and biological properties were observed for zein/Ag-Sr doped MBGN coatings. Results suggested these zein/Ag-Sr MBGNs coatings have great potential in bone regeneration applications.

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“…After 21 days, the results indicated that the corrosion rate of samples immersed in EBSS buffered with sodium bicarbonate was similar to that obtained in vivo. In addition to EBSS, cell culture media, such as DMEM and MEM, are preferable to investigate the corrosion behavior of Mg-based biomaterials [88][89][90].…”

Section: Mg Corrosion In Simulated Body Environmentsmentioning

confidence: 99%

Biodegradable Magnesium Biomaterials—Road to the Clinic

Amukarimi

Mozafari

2022

Bioengineering

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In recent decades, we have witnessed radical changes in the use of permanent biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without releasing toxic degradation products has led to a vast range of applications in the biomedical field, including cardiovascular stents, musculoskeletal, and orthopedic applications. With the use of biodegradable Mg biomaterials, patients would not suffer second surgery and surgical pain anymore. Be that as it may, the main drawbacks of these biomaterials are the high corrosion rate and unexpected degradation in physiological environments. Since biodegradable Mg-based implants are expected to show controllable degradation and match the requirements of specific applications, various techniques, such as designing a magnesium alloy and modifying the surface characteristics, are employed to tailor the degradation rate. In this paper, some fundamentals and particular aspects of magnesium degradation in physiological environments are summarized, and approaches to control the degradation behavior of Mg-based biomaterials are presented.

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Zein/Bioactive Glass Coatings with Controlled Degradation of Magnesium under Physiological Conditions: Designed for Orthopedic Implants

Cited by 19 publications

References 37 publications

Chitosan/gelatin‐based bioactive and antibacterial coatings deposited via electrophoretic deposition

Chitosan/gelatin‐based bioactive and antibacterial coatings deposited via electrophoretic deposition

Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications

Biodegradable Magnesium Biomaterials—Road to the Clinic

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