Zebrafish models relevant to studying central opioid and endocannabinoid systems

Demin, Konstantin A.; Meshalkina, Darya A.; Kysil, Elana V.; Antonova, Kristina A.; Volgin, Andrey D.; Yakovlev, Oleg A.; Alekseeva, Polina A.; Firuleva, Maria M.; Lakstygal, Anton M.; Abreu, Murilo S. de; Barcellos, Leonardo José Gil; Bao, Wandong; Friend, Ashton J.; Amstislavskaya, Tamara G.; Rosemberg, Denis B.; Musienko, Pavel; Song, Cai; Kalueff, Allan V.

doi:10.1016/j.pnpbp.2018.03.024

Cited by 50 publications

(26 citation statements)

References 193 publications

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“…Zebrafish is an outstanding model system to study vertebrate development. It is increasingly becoming a popular model to study the effects of exposure to different compounds during development because of its various advantages compared to the avian or mammalian systems [ 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. It is easy to expose externally fertilized embryos to different drugs and to monitor their effects on development in transparent embryos.…”

Section: Zebrafish: a Model System To Study The Effect Of Marijuanmentioning

confidence: 99%

“…Unlike invertebrates, the eCB system is highly conserved between zebrafish and mammals, including humans. The zebrafish contain orthologs of all human cannabinoid signaling genes except N-acylethanolamine acid amidase gene [ 40 , 58 , 59 ]. Another difference is that zebrafish have two homologs for each of the four human genes FAAH2, PTGS2, TRPA1, and PPARA.…”

Section: Zebrafish: a Model System To Study The Effect Of Marijuanmentioning

confidence: 99%

“…Another difference is that zebrafish have two homologs for each of the four human genes FAAH2, PTGS2, TRPA1, and PPARA. Zebrafish Cnr1 and Cnr2 share 75% and 46% identity with their human counterparts [ 40 , 58 ].…”

Section: Zebrafish: a Model System To Study The Effect Of Marijuanmentioning

confidence: 99%

“…An extensive body of research on the expression and the functions of zebrafish eCB genes are summarized in recent reviews [ 40 , 45 , 58 , 59 ]. During development, the expression of zebrafish cannabinoid receptor 1 ( cnr1 ) was first detected in the pre-optic area as early as 1 day post fertilization (dpf).…”

Section: Zebrafish: a Model System To Study The Effect Of Marijuanmentioning

confidence: 99%

“…The NOP system is considered to be a part of the opioid system, although it produces antiopioid actions depending on the region in which it is expressed in the brain. These receptors are activated by endogenous ligands ß-endorphin (MORP ligand), dynorphin (KORP ligand), enkephalin and deltorphin (DORP ligand), nociceptin/orphanin FQ (N/OFQ) (NOP ligand) that result in physiological effects including analgesia, dysphoria, water diuresis, and antipruritic effects [ 40 , 45 ]. These ligands are derived from precursor compounds that are produced by the genes POMC, PENK, PDYN, and PNOC.…”

Section: Zebrafish: a Model System To Study The Effect Of Marijuanmentioning

confidence: 99%

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Marijuana and Opioid Use during Pregnancy: Using Zebrafish to Gain Understanding of Congenital Anomalies Caused by Drug Exposure during Development

Sarmah

Cadena

2020

Biomedicines

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Marijuana and opioid addictions have increased alarmingly in recent decades, especially in the United States, posing threats to society. When the drug user is a pregnant mother, there is a serious risk to the developing baby. Congenital anomalies are associated with prenatal exposure to marijuana and opioids. Here, we summarize the current data on the prevalence of marijuana and opioid use among the people of the United States, particularly pregnant mothers. We also summarize the current zebrafish studies used to model and understand the effects of these drug exposures during development and to understand the behavioral changes after exposure. Zebrafish experiments recapitulate the drug effects seen in human addicts and the birth defects seen in human babies prenatally exposed to marijuana and opioids. Zebrafish show great potential as an easy and inexpensive model for screening compounds for their ability to mitigate the drug effects, which could lead to new therapeutics.

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Section: Zebrafish: a Model System To Study The Effect Of Marijuanmentioning

confidence: 99%

Section: Zebrafish: a Model System To Study The Effect Of Marijuanmentioning

confidence: 99%

Section: Zebrafish: a Model System To Study The Effect Of Marijuanmentioning

confidence: 99%

Section: Zebrafish: a Model System To Study The Effect Of Marijuanmentioning

confidence: 99%

Section: Zebrafish: a Model System To Study The Effect Of Marijuanmentioning

confidence: 99%

See 3 more Smart Citations

Marijuana and Opioid Use during Pregnancy: Using Zebrafish to Gain Understanding of Congenital Anomalies Caused by Drug Exposure during Development

Sarmah

Cadena

2020

Biomedicines

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Zebrafish in Drug Discovery: Safety Assessment

Cassar

2022

Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

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Evolution, Sex and Pain. Multiple Faces of the Dice

M. Garcia,

Martín Ruiz

2024

Tales of Discovery

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Zebrafish models relevant to studying central opioid and endocannabinoid systems

Cited by 50 publications

References 193 publications

Marijuana and Opioid Use during Pregnancy: Using Zebrafish to Gain Understanding of Congenital Anomalies Caused by Drug Exposure during Development

Marijuana and Opioid Use during Pregnancy: Using Zebrafish to Gain Understanding of Congenital Anomalies Caused by Drug Exposure during Development

Zebrafish in Drug Discovery: Safety Assessment

Evolution, Sex and Pain. Multiple Faces of the Dice

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