Zebrafish models of diabetes-related CNS pathogenesis

Lakstygal, Anton M.; Abreu, Murilo S. de; Lifanov, Dmitry A.; Wappler-Guzzetta, Edina A.; Serikuly, Nazar; Alpsyshov, Erik T.; Wang, Dongmei; Wang, Mengyao; Tang, Zhichong; Yan, Dongni; Demin, Konstantin A.; Volgin, Andrey D.; Amstislavskaya, Tamara G.; Wang, JiaJia; Song, Cai; Alekseeva, Polina A.; Kalueff, Allan V.

doi:10.1016/j.pnpbp.2018.11.016

Cited by 19 publications

(10 citation statements)

References 191 publications

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“…STZ‐treated and HFD‐fed mice displayed impaired neurogenesis and reduced levels of the synaptophysin, postsynaptic density 95 (PSD‐95), nestin, doublecortin (DCX), and resulted in dysfunctional insulin signaling (Wongchitrat et al., 2016). The zebrafish is an upcoming and promising vertebrate model for “diabetes‐related‐CNS pathogenesis” research (Lakstygal et al., 2019). With the radial glial cells serving as the neural stem cells (NSCs) in the brain of the adult zebrafish telencephalon, they are capable of not only constitutive but regenerative neurogenesis as well (Anand & Mondal, 2018).…”

Section: Physiological Factors That Play Key Roles In the Comorbiditymentioning

confidence: 99%

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Subba

Sandhir

Singh

et al. 2021

Eur J of Neuroscience

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Diabetes increases the likelihood of developing depression and vice versa. Research on this bidirectional association has somewhat managed to delineate the interplay among implicated physiological processes. Still, further exploration is required in this context. This review addresses the comorbidity by investigating suspected common pathophysiological mechanisms. One such factor is psychological stress which disturbs the hypothalamic–pituitary–adrenal axis causing hormonal imbalance. This includes elevated cortisol levels, a common biomarker of both depression and diabetes. Disrupted insulin signaling drives the hampered neurotransmission of serotonin, dopamine, and norepinephrine. Also, adipokine hormones such as adiponectin, leptin, and resistin and the orexigenic hormone, ghrelin, are involved in both depression and T2DM. This disarray further interferes with physiological processes encompassing sleep, the gut–brain axis, metabolism, and mood stability. Behavioral coping mechanisms, such as unhealthy eating, mediate disturbed glucose homeostasis, and neuroinflammation. This is intricately linked to oxidative stress, redox imbalance, and mitochondrial dysfunction. However, interventions such as psychotherapy, physical exercise, fecal microbiota transplantation, and insulin‐sensitizing agents can help to manage the distressing condition. The possibility of glucagon‐like peptide 1 possessing a therapeutic role has also been discussed. Nonetheless, there stands an urgent need for unraveling new correlating targets and biological markers for efficient treatment.

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Section: Physiological Factors That Play Key Roles In the Comorbiditymentioning

confidence: 99%

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Subba

Sandhir

Singh

et al. 2021

Eur J of Neuroscience

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“…Given the substantial number of metabolism‐associated genes shared with humans, 59 the zebrafish model has been extensively employed to investigate the relationship between different metabolic patterns and the gut microbiome. Substantial evidence suggests that changes in the gut microbiome and their metabolites are closely related to glucose metabolism, insulin resistance, and recovery of pancreatic function in type 2 diabetes mellitus (T2DM) 60 .…”

Section: The Roles Of the Gut Microbiome In Tissue Development And Ph...mentioning

confidence: 99%

Application of zebrafish in the study of the gut microbiome

Zhong

et al. 2022

Anim Models and Exp Med

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The gut microbiome is widely acknowledged to coexist with the animal host, consisting of symbiotic and pathogenic bacteria in a dynamic balance state that produce a wide variety of signaling molecules. These bacteria colonize the intestine and perform functions the host itself cannot accomplish; in turn, they rely on the habitat provided by the host. A healthy gut microbiome plays a significant and irreplaceable role in determining the host's overall health.Zebrafish is an omnivorous freshwater fish that belongs to the small carp family. It has been widely used for research purposes on embryology and tissue regeneration, molecular genetics, reproductive biology, and toxicology given its numerous advantages, including high fecundity, short lifespan, highly annotated genome, optical

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“…For example, the genome duplication event in teleost fishes [ 219 ] complicates genetic analyses of pain responses since some pain-related genes may exist in two copies or be missing in zebrafish. Because of its small size, the long-term monitoring of endocrine levels from blood ( e.g., glucose levels) is also problematic as it is difficult to obtain a sufficient amount of blood without euthanizing the animal [ 220 ].…”

Section: Advantages and Limitations Of Zebrafish Models In Anti-pain ...mentioning

confidence: 99%

The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns

Costa

Rosa

Quadros

et al. 2022

Self Cite

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: The ability of the nervous system to detect a wide range of noxious stimuli is crucial to avoid life-threatening injury and to trigger protective behavioral and physiological responses. Pain represents a complex phenomenon, including nociception associated with cognitive and emotional processing. Animal experimental models have been developed to understand the mechanisms involved in pain response, as well as to discover novel pharmacological and non-pharmacological anti-pain therapies. Due to the genetic tractability, similar physiology, low cost, and rich behavioral repertoire, the zebrafish (Danio rerio) has been considered a powerful aquatic model for modeling pain responses. Here, we summarize the molecular machinery of zebrafish to recognize painful stimuli, as well as emphasize how zebrafish-based pain models have been successfully used to understand specific molecular, physiological, and behavioral changes following different algogens and/or noxious stimuli (e.g., acetic acid, formalin, histamine, Complete Freund's Adjuvant, cinnamaldehyde, allyl isothiocyanate, and fin clipping). We also discuss recent advances in zebrafish-based studies and outline the potential advantages and limitations of the existing models to examine the mechanisms underlying pain responses from an evolutionary and translational perspective. Finally, we outline how zebrafish models can represent emergent tools to explore pain behaviors and pain-related mood disorders, as well as to facilitate analgesic therapy screening in translational pain research.

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Zebrafish models of diabetes-related CNS pathogenesis

Cited by 19 publications

References 191 publications

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Application of zebrafish in the study of the gut microbiome

The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns

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