Zebrafish <i>phd3</i> Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity

Yu, Guangqing; Li, Xiong; Zhou, Ziwen; Tang, Jinhua; Wang, Jing; Liu, Xing; Fan, Sijia; Ouyang, Gang; Xiao, Wuhan

doi:10.4049/jimmunol.1900902

Cited by 8 publications

(4 citation statements)

References 58 publications

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“…In certain cases, some genes are responsible for suppressing cellular antiviral responses; for example, Yu et al knocked out a single gene, Phd3, that led to an increased rate of survival when zebrafish were exposed to SVCV. 340 Findings such as these have the potential to have a significant impact on the future of breeding programs and disease response in aquaculture.…”

Section: Disease Resistancementioning

confidence: 99%

“…Studies focusing on innate immunity have targeted immune-related genes that regulate gene expression or disturb certain pathways. [338][339][340] Pattern recognition receptors (PRRs) detect the presence of pathogen-associated molecular patterns. 341,342 In fishes, retinoic acid-inducible gene receptors (RIGR) and toll-like receptors (TLRs) are two key classes of PRRs that play a major role in innate immunity.…”

Section: Disease Resistancementioning

confidence: 99%

“…Therefore, gene editing research for disease‐resistant traits has primarily focused on innate immunity or gene function after exposure. Studies focusing on innate immunity have targeted immune‐related genes that regulate gene expression or disturb certain pathways 338–340 . Pattern recognition receptors (PRRs) detect the presence of pathogen‐associated molecular patterns 341,342 .…”

Section: Traits To Optimisementioning

confidence: 99%

“…When Sirt5 was knocked out in zebrafish, genes with antiviral response were enhanced, replication of spring viremia of carp virus (SVCV) was diminished, and survival rate was increased after the fish were challenged with SVCV. In certain cases, some genes are responsible for suppressing cellular antiviral responses; for example, Yu et al knocked out a single gene, Phd3 , that led to an increased rate of survival when zebrafish were exposed to SVCV 340 . Findings such as these have the potential to have a significant impact on the future of breeding programs and disease response in aquaculture.…”

Section: Traits To Optimisementioning

confidence: 99%

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Optimising commercial traits through gene editing in aquaculture: Strategies for accelerating genetic improvement

Moran,

Jones,

Jensen

et al. 2023

Reviews in Aquaculture

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Aquaculture is one of the fastest‐growing food production sectors. As the global human population continues to increase and further pressure is added to the prospects of achieving global food security, aquaculture is expected to play an integral role in meeting future nutrition demands. With advances in genetic technologies over recent years, much progress has been made within the realm of selective breeding. Despite success, selective breeding programs have limitations to the rate of genetic gain they can achieve. The incorporation of targeted genetic technologies, such as gene editing, into research related to selective breeding programs will help identify specific genes related to commercially desirable traits, as well as expedite genetic improvement. This review summarises research encompassing the most commonly targeted traits using gene editing within aquaculture, namely reproduction and development, pigmentation, growth and disease resistance. In addition, this review illustrates how the incorporation of gene editing can expedite genetic improvement through the rapid fixation of desirable alleles, as well as suggests strategies to accelerate genetic improvement for aquaculture production.

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Section: Disease Resistancementioning

confidence: 99%