Zebrafish Foxc1a controls ventricular chamber maturation by directly regulating wwtr1 and nkx2.5 expression

He, Luqingqing; Zhang, Qinxin; Jiang, Dongya; Zhang, Yunfeng; Wei, Yuxuan; Yang, Yanchun; Li, Nan; Wang, Shuang; Yue, Yunyun; Zhao, Qingshun

doi:10.1016/j.jgg.2021.12.002

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…In cardiac development, Foxc1a is a key regulator in cardiac progenitor cell specification. He et al. (2022) reveal a new role of Foxc1a in modulating chamber maturation by downregulating wwtr1 and nkx2.5 in zebrafish.…”

mentioning

confidence: 86%

JGG in 2022: challenges, opportunities, and prospects

Guo

Song

Zuo

2023

Journal of Genetics and Genomics

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mentioning

confidence: 86%

JGG in 2022: challenges, opportunities, and prospects

Guo

Song

Zuo

2023

Journal of Genetics and Genomics

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“…TAZ regulates cardiomyocyte expression of the tp1 Notch reporter gene in a cell-autonomous manner, promoting the maturation of cardiac trabeculae. Simultaneously, developing hearts with TAZ deficiency exhibit differentially expressed genes, among which, genes regulating the actomyosin network, including myosin heavy chain 10(myh10) and myosin binding protein Hb ( mybphb ), affect the maturation of trabeculae ( Xin et al, 2013 ; Lai et al, 2018 ; He et al, 2022 ). The knockout of YAP/TAZ in the epicardium of mouse embryos is embryonically lethal, resulting in defective coronary arteries ( Singh et al, 2016 ; Xiao et al, 2018 ).…”

Section: Ncrna/hippo Pathway In Cardiac Developmentmentioning

confidence: 99%

Non-coding RNAs as regulators of the Hippo pathway in cardiac development and cardiovascular disease

Song,

Wang,

Liu

et al. 2024

Front. Pharmacol.

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Cardiovascular diseases pose a serious threat to human health. The onset of cardiovascular diseases involves the comprehensive effects of multiple genes and environmental factors, and multiple signaling pathways are involved in regulating the occurrence and development of cardiovascular diseases. The Hippo pathway is a highly conserved signaling pathway involved in the regulation of cell proliferation, apoptosis, and differentiation. Recently, it has been widely studied in the fields of cardiovascular disease, cancer, and cell regeneration. Non-coding RNA (ncRNAs), which are important small molecules for the regulation of gene expression in cells, can directly target genes and have diverse regulatory functions. Recent studies have found that ncRNAs interact with Hippo pathway components to regulate myocardial fibrosis, cardiomyocyte proliferation, apoptosis, and hypertrophy and play an important role in cardiovascular disease. In this review, we describe the mode of action of ncRNAs in regulating the Hippo pathway, provide new ideas for further research, and identify molecules involved in the mechanism of action of ncRNAs and the Hippo pathway as potential therapeutic targets, with the aim of finding new modes of action for the treatment and prevention of cardiovascular diseases.

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“…Accordingly, a safer approach is warranted to minimize reperfusion injury in myocardial infarction. Nkx2.5 is an early cardiovascular transcription factor ( Thiele et al, 2019 ), and its specific deletion can lead to cardiac abnormalities( He et al, 2022 ), suggesting the importance of Nkx2.5 for heart development and growth. Continuous Baicalin treatment can induce functional myocardium formation of embryonic stem cell line D3 by up-regulating the transcription of Nkx2.5 at the intermediate and late stages of differentiation ( Tang et al, 2013 ) ( Figure 2A ).…”

Section: Baicalin and Embryonic Stem Cellsmentioning

confidence: 99%