Zebrafish based strategy for the identification of a potential pharmacophore for apoptosis: a greener CuAAC approach for novel 1,2,3-triazoles derived from mefenamic acid

CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review

“…This necessity for novel chemotherapeutics has reinvigorated various research groups to synthesize triazole analogs. 11,12 A compiled report on the pharmacological applications of 1,2,3triazole linked molecules created via copper catalysed alkyneazide cycloaddition (CuAAC) reaction has not been published to the best of our knowledge. This review contains the compiled data of research articles published in the last 10 years (2010 onwards) with active pharmacological entities.…”

Synthesis of hybrid perillyl‐4H‐pyrans. Cytotoxicity evaluation against hepatocellular carcinoma HepG2/C3A cell line

“…[ 55 ] Heterogeneous catalysis, greener process or ultrasound‐promoted reaction also brought technical improvements performing this methodology. [ 56–58 ] Thus, the 4‐arylpropargyloxy‐4 H ‐pyrans 10a–o were used as substrate for the preparation of hybrid compounds by reaction with perillyl azide ( 14 ) under catalysis of CuSO 4 /Na‐ascorbate system (Scheme 5). The results are shown in Table , below.…”

Semi-synthesis of β-keto-1,2,3-triazole derivatives from ethinylestradiol and evaluation of the cytotoxic activity

“…Also there are studies in the literature describing the synthesis and evaluation of biological activity of other 1,2,3-triazole derivates [22, 23, 24, 25]. The coumarin-1,2,3-triazole-dithiocarbamate hybrids were designed, synthesized and evaluated for their inhibitory activity towards lysine specific demethylase 1 (LSD1).…”