ZEB1-dependent modulation of fibroblast polarization governs inflammation and immune checkpoint blockade sensitivity in colorectal cancer

Schuhwerk, Harald; Menche, Constantin; Armstark, Isabell; Gupta, Pooja; Fuchs, Kathrin; Roey, Ruthger van; Mosa, Mohammed H.; Geppert, Carol; Bärthel, Stefanie; Saur, Dieter; Greten, Florian R.; Brabletz, Simone; Brabletz, Thomas; Farin, Henner F.; Stemmler, Marc P.

doi:10.1101/2023.03.28.534565

Cited by 2 publications

(1 citation statement)

References 71 publications

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“…Novel aspects of EMT-TF function came from observations that their expression is not limited to tumor cells, as they were also found to be upregulated in tumor stroma cells. Marc Stemmler (Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany) exploited a mouse model for colorectal cancer to find that Zeb1 expression drives cell plasticity also in cancer-associated fibroblasts in favor of tumor progression and immune evasion [15].…”

Section: Emt Pathways In Tumor Stroma and Links To Immune Responsementioning

confidence: 99%

Twenty Years of Epithelial-Mesenchymal Transition: A State of the Field from TEMTIA X

Savagner,

Brabletz,

Cheng

et al. 2024

Cells Tissues Organs

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This report summarizes the 10th biennial meeting of The Epithelial Mesenchymal Transition International Association (TEMTIA), that took place in Paris on November 7–10, 2022. It provides a short but comprehensive introduction to the presentations and discussions that took place during the 3-day meeting. Similarly to previous TEMTIA meetings, TEMTIA X reviewed the most recent aspects of the epithelial-mesenchymal transition (EMT), a cellular process involved during distinct stages of development but also during wound healing and fibrosis to some degree. EMT has also been associated at various levels during tumor cell progression and metastasis. The meeting emphasized the intermediate stages of EMT (partial EMT or EM hybrid cells) involved in the malignant process and their potential physiological or pathological importance, taking advantage of advancements in molecular methods at the single-cell level. It also introduced novel descriptions of EMT occurrences during early embryogenesis. Sessions explored relationships between EMT and cell metabolism and how EMT can affect immune responses, particularly during tumor progression, providing new targets for cancer therapy. Finally, it introduced a new perception of EMT biological meaning based on an evolutionary perspective. The meeting integrated the TEMTIA general assembly, allowing general discussion about the future of the association and the site of the next meeting, now decided to take place in Seattle, USA, in November 2024. This report provides a comprehensive introduction to the presentations and discussions that took place during the 10th biennial meeting of TEMTIA, that occurred in Paris on November 7–10, 2022. It includes all the sessions and follows the chronological order during the 3-day meeting. A general purpose of the meeting was to explore the boundaries of the EMT process, including new concepts and developments, as illustrated by our leitmotiv for the meeting, inspired by the proximity of the Cluny Museum in Paris.

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Section: Emt Pathways In Tumor Stroma and Links To Immune Responsementioning

confidence: 99%

Twenty Years of Epithelial-Mesenchymal Transition: A State of the Field from TEMTIA X

Savagner,

Brabletz,

Cheng

et al. 2024

Cells Tissues Organs

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Transcription factors in fibroblast plasticity and CAF heterogeneity

Melchionna,

Trono,

Di Carlo

et al. 2023

J Exp Clin Cancer Res

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In recent years, research focused on the multifaceted landscape and functions of cancer-associated fibroblasts (CAFs) aimed to reveal their heterogeneity and identify commonalities across diverse tumors for more effective therapeutic targeting of pro-tumoral stromal microenvironment. However, a unified functional categorization of CAF subsets remains elusive, posing challenges for the development of targeted CAF therapies in clinical settings.The CAF phenotype arises from a complex interplay of signals within the tumor microenvironment, where transcription factors serve as central mediators of various cellular pathways. Recent advances in single-cell RNA sequencing technology have emphasized the role of transcription factors in the conversion of normal fibroblasts to distinct CAF subtypes across various cancer types.This review provides a comprehensive overview of the specific roles of transcription factor networks in shaping CAF heterogeneity, plasticity, and functionality. Beginning with their influence on fibroblast homeostasis and reprogramming during wound healing and fibrosis, it delves into the emerging insights into transcription factor regulatory networks. Understanding these mechanisms not only enables a more precise characterization of CAF subsets but also sheds light on the early regulatory processes governing CAF heterogeneity and functionality. Ultimately, this knowledge may unveil novel therapeutic targets for cancer treatment, addressing the existing challenges of stromal-targeted therapies.

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ZEB1-dependent modulation of fibroblast polarization governs inflammation and immune checkpoint blockade sensitivity in colorectal cancer

Cited by 2 publications

References 71 publications

Twenty Years of Epithelial-Mesenchymal Transition: A State of the Field from TEMTIA X

Twenty Years of Epithelial-Mesenchymal Transition: A State of the Field from TEMTIA X

Transcription factors in fibroblast plasticity and CAF heterogeneity

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