Zearalenone interferes with the sperm-triggered inflammation in the bovine uterus in vitro: Negative impact on sperm motility and survival

Elweza, Ahmed E.; Marey, Mohamed Ali; Elesh, Ibrahim; Zinnah, Mohammad Ali; Akthar, Ihshan; Kanno, Chihiro; Takagi, Mitsuhiro; Miyamoto, Akio

doi:10.1016/j.reprotox.2021.12.001

Cited by 5 publications

(1 citation statement)

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“…In vitro results of Lee et al [ 118 ] also report apoptosis and autophagy of the investigated spermatogonia cell line. Pre-exposure of bovine endometrial epithelial cells to ZEA induced pro-inflammatory cytokines (TNFA, IL1B), and chemokine IL8 mRNA upregulation resulted in altered sperm–uterine crosstalk which was manifested in suppressed sperm motility [ 134 ]. ZEA is capable of negatively influencing spermatogenesis by its oxidative stress-inducing ability.…”

Section: Overview Of the Pathogenesis Of Zearalenonementioning

confidence: 99%

Estrogenic and Non-Estrogenic Disruptor Effect of Zearalenone on Male Reproduction: A Review

Balló

Székvári²,

Czétány

et al. 2023

IJMS

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According to some estimates, at least 70% of feedstuffs and finished feeds are contaminated with one or more mycotoxins and, due to its significant prevalence, both animals and humans are highly likely to be exposed to these toxins. In addition to health risks, they also cause economic issues. From a healthcare point of view, zearalenone (ZEA) and its derivatives have been shown to exert many negative effects. Specifically, ZEA has hepatotoxicity, immunotoxicity, genotoxicity, carcinogenicity, intestinal toxicity, reproductive toxicity and endocrine disruption effects. Of these effects, male reproductive deterioration and processes that lead to this have been reviewed in this study. Papers are reviewed that demonstrate estrogenic effects of ZEA due to its analogy to estradiol and how these effects may influence male reproductive cells such as spermatozoa, Sertoli cells and Leydig cells. Data that employ epigenetic effects of ZEA are also discussed. We discuss literature data demonstrating that reactive oxygen species formation in ZEA-exposed cells plays a crucial role in diminished spermatogenesis; reduced sperm motility, viability and mitochondrial membrane potential; altered intracellular antioxidant enzyme activities; and increased rates of apoptosis and DNA fragmentation; thereby resulting in reduced pregnancy.

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Section: Overview Of the Pathogenesis Of Zearalenonementioning

confidence: 99%