Zearalenone as an endocrine disruptor in humans

Kowalska, Karolina; Habrowska-Górczyńska, Dominika Ewa; Piastowska-Ciesielska, Agnieszka Wanda

doi:10.1016/j.etap.2016.10.015

Cited by 195 publications

(135 citation statements)

References 67 publications

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“…ZEA causes significant alterations in the reproductive tract of laboratory and domestic animals. Infertility, swelling of the uterus and vulva, increased embryolethal resorptions, and atrophy of ovaries have been observed in mice, rats, guinea pigs, and rabbits [46]. In cattle, consuming feed contaminated with high amount of ZEA may be directly associated with infertility, reduced milk production, and hyperestrogenism [47].…”

Section: Occurrence and Toxicity Of Major Mycotoxinsmentioning

confidence: 99%

Occurrence, Toxicity, and Analysis of Major Mycotoxins in Food

Alshannaq

2017

IJERPH

878

573

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Mycotoxins are toxic secondary metabolites produced by certain filamentous fungi (molds). These low molecular weight compounds (usually less than 1000 Daltons) are naturally occurring and practically unavoidable. They can enter our food chain either directly from plant-based food components contaminated with mycotoxins or by indirect contamination from the growth of toxigenic fungi on food. Mycotoxins can accumulate in maturing corn, cereals, soybeans, sorghum, peanuts, and other food and feed crops in the field and in grain during transportation. Consumption of mycotoxin-contaminated food or feed can cause acute or chronic toxicity in human and animals. In addition to concerns over adverse effects from direct consumption of mycotoxin-contaminated foods and feeds, there is also public health concern over the potential ingestion of animal-derived food products, such as meat, milk, or eggs, containing residues or metabolites of mycotoxins. Members of three fungal genera, Aspergillus, Fusarium, and Penicillium, are the major mycotoxin producers. While over 300 mycotoxins have been identified, six (aflatoxins, trichothecenes, zearalenone, fumonisins, ochratoxins, and patulin) are regularly found in food, posing unpredictable and ongoing food safety problems worldwide. This review summarizes the toxicity of the six mycotoxins, foods commonly contaminated by one or more of them, and the current methods for detection and analysis of these mycotoxins.

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Section: Occurrence and Toxicity Of Major Mycotoxinsmentioning

confidence: 99%

Occurrence, Toxicity, and Analysis of Major Mycotoxins in Food

Alshannaq

2017

IJERPH

878

573

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“…If not removed during the manufacturing process, this mycotoxin affects the food chain through several food products, including maize, wheat, barley, oat and sorghum. Edible oils, nuts, spices, milk, egg, meat, wine, beer and even water can be additional routes of exposure . The wide occurrence and high thermal stability of ZEA make its elimination from the food chain very difficult …”

Section: Introductionmentioning

confidence: 99%

“…Edible oils, nuts, spices, milk, egg, meat, wine, beer and even water can be additional routes of exposure. [4][5][6] The wide occurrence and high thermal stability of ZEA make its elimination from the food chain very difficult. 7 Low amounts of ZEA can be transported from contaminated agricultural fields to the aquatic environment via run-off and it can be detected in a variety of waters such as groundwater, drainage water and river water, and at wastewater treatment plants.…”

Section: Introductionmentioning

confidence: 99%

Biosorptive detoxification of zearalenone biotoxin by surface‐modified renewable biomass: process dynamics and application

et al. 2018

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BACKGROUND Contamination of food, feed, beverages and even drinking water with biotoxins is a growing global concern because of their potential health risks. In this work, surface‐modified sugar beet pulp waste was used for the biosorptive removal of zearalenone biotoxin from contaminated aquatic media. RESULTS Infrared, Boehm titration, BET (Brunauer–Emmett–Teller) surface area and point of zero charge analysis were employed for surface characterization. Kinetic and equilibrium studies showed that biotoxin biosorption was well predicted by the pseudo‐second‐order kinetic model and the Langmuir isotherm model. Zearalenone was removed from the solution over a wide pH range (3.0–8.0) and within a short time (15 min). Maximum uptake capacity of modified biomass was recorded as 23.30 ± 0.17 g kg−1. Highest removal yield in a dynamic flow mode (94.56 ± 0.13%) was achieved at 2 mL min−1 flow rate using 30 mg biosorbent. Regeneration experiments revealed high reusability potential of suggested biosorbent. Moreover, its application potential was tested in spiked samples of malt, beer and canned corn liquid. CONCLUSION Detoxification potential of this renewable biomass was significantly enhanced after modification. Modified biomass could be used as an efficient and low‐cost green‐type material with good application potential for zearalenone detoxification. © 2018 Society of Chemical Industry

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“…As mentioned before, steroids counteract in many physiological processes; thus, its disturbances might result in developmental defects, infertility as well as other reproductive disruptions (Odermatt et al, ). It is also known that exogenous chemicals might modulate the process of steroidogenesis (Odermatt et al, ), which could contribute to obesity, diabetes (Zhao, Li, Wang, Yan, & Li, ), neurological disorders (Frye et al, ) as well as prostate and breast cancer (Kowalska, Habrowska‐Górczyńska, & Piastowska‐Ciesielska, ). Thus, more research studies are nowadays focused on the molecular background of endocrine disrupting chemical effects on the process of steroidogenesis (Odermatt et al, ).…”

Section: Steroidogenesismentioning

confidence: 99%

Deoxynivalenol as potential modulator of human steroidogenesis

Urbanek

Habrowska-Górczyńska

Kowalska

et al. 2018

J of Applied Toxicology

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Deoxynivalenol (DON) is a type B trichothecene, produced by the Fusarium species. Exposure to DON might cause disruptive effects such as reduced weight gain, neuroendocrine changes and immune modulation in animals (rats, dogs, pigs). There is huge concern that similar effects can be observed in humans. DON is a potential regulator of intracellular steroidogenesis. It is also possible that DON will be involved in the regulation of miRNAs connected with steroidogenesis. This review summarizes the latest knowledge about the influence of DON on steroidogenesis and human hormonal balance.

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Zearalenone as an endocrine disruptor in humans

Cited by 195 publications

References 67 publications

Occurrence, Toxicity, and Analysis of Major Mycotoxins in Food

Occurrence, Toxicity, and Analysis of Major Mycotoxins in Food

Biosorptive detoxification of zearalenone biotoxin by surface‐modified renewable biomass: process dynamics and application

Deoxynivalenol as potential modulator of human steroidogenesis

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