Zearalanol Metabolism in Steers

Sharp, Gillian; Dyer, I. A.

doi:10.2527/jas1972.341176x

Cited by 32 publications

(10 citation statements)

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“…The implant compound, ␣-zearalanol (zeranol) and its metabolite ␤-zearalenol, were detected in manure collected from both hormone treated or untreated animals and from control plots. The presence of these compounds in manure collected from untreated animals or control plots may be attributed to formation of Fusarium mold that may have been present in corn silage or grain included in feed rations [14,39,40]. Lack of detections of synthetic hormones in manure is consistent with previous studies and may be attributed to rapid degradation during composting [13,41].…”

Section: Manure Analysissupporting

confidence: 86%

Effect of rainfall timing and tillage on the transport of steroid hormones in runoff from manure amended row crop fields

Biswas

Kranz

Shapiro

et al. 2017

Journal of Hazardous Materials

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h i g h l i g h t s• Hormones and metabolites were detected in runoff from test plots fertilized with cattle manure.• Composting can reduce the hormone concentration in manure compared to stockpiling.• About 10% of applied hormones can be lost through the dissolved phase of runoff. a r t i c l e i n f o a b s t r a c tRunoff generated from livestock manure amended row crop fields is one of the major pathways of hormone transport to the aquatic environment. The study determined the effects of manure handling, tillage methods, and rainfall timing on the occurrence and transport of steroid hormones in runoff from the row crop field. Stockpiled and composted manure from hormone treated and untreated animals were applied to test plots and subjected to two rainfall simulation events 30 days apart. During the two rainfall simulation events, detection of any steroid hormone or metabolites was identified in 8-86% of runoff samples from any tillage and manure treatment. The most commonly detected hormones were 17␤-estradiol, estrone, estriol, testosterone, and ␣-zearalenol at concentrations ranging up to 100-200 ng L −1 . Considering the maximum detected concentrations in runoff, no more than 10% of the applied hormone can be transported through the dissolved phase of runoff. Results from the study indicate that hormones can persist in soils receiving livestock manure over an extended period of time and the dissolved phase of hormone in runoff is not the preferred pathway of transport from the manure applied fields irrespective of tillage treatments and timing of rainfall.

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Section: Manure Analysissupporting

confidence: 86%

Effect of rainfall timing and tillage on the transport of steroid hormones in runoff from manure amended row crop fields

Biswas

Kranz

Shapiro

et al. 2017

Journal of Hazardous Materials

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“…An abiIity to increase the rate of growth of cattle, a lack of side effects in treated animals, and an absence of residues in human food after implantation of cattle (Sharp and Dyer, 1972); Brown, 1972) indicated potential application for zeranol in the Australian beef industry.…”

Section: Introductionmentioning

confidence: 99%

Effect of Subcutaneous Implants of Zeranol on Weight Gains of Castrated Cattle at Pasture†

Sammons

1980

Aust Veterinary J

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Eight experiments involving a total of 480 castrated cattle grazing Australian pastures were conducted to assess the effect of subcutaneous implants of 36 mg zeranol on weight gain. A wide range of cattle ages, bodyweights and environmental and nutritional conditions was involved. Growth rates of untreated cattle ranged from minus 0.15 kg/day over 90 days to 1.23 kg/day over 52 days. In the other, cattle in both implanted and control groups lost weight over the duration of the experiment. Whilst the bodyweight of implanted cattle was less than that of untreated cattle the carcase weight of implanted cattle was 2.4 kg greater than for control cattle. Neither of these differences was significant (P > 0.10). No side effects were noted in any of the treated cattle.

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“…The development of alternative and safer anabolic agents has resulted in the widespread use of the oestrogenic compound zeranol which is derived from the naturally-occurring mycotoxin and oestrogen zearalenone (Hidy, Baldwin, Greasham, Keith & McMullen, 1977). Sharp & Dyer (1972) claim from their radiometric studies in steers that zeranol 0 1980 Blackwell Scientific Publications 0140-7783/80/0900-0177 $02.00 residues were present in bile, urine, faeces and at the site of implantation but were not detected in other tissues 65 days after implantation of 186 pCi, 72 mg of 3H-zeranol. The lower limit of sensitivity of their assay was 20 ppb.…”

Section: Introductionmentioning

confidence: 99%

Radioimmunoassay of the anabolic agent zeranol I. Preparation and properties of a specific antibody to zeranol

Dixon

1980

Vet Pharm & Therapeutics

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A highly specific antibody has been raised in sheep to an antigen prepared by coupling zeranol hemisuccinate to bovine serum albumin. An assay procedure is described and has been used to measure the cross‐reactivity of the antiserum, and evaluate the sensitivity of the assay method. The only compounds which reacted with the antibody were zeranol 100%, zearalanone 100%, zearalenone 19% and zearalenol 19%. The sensitivity of the assay procedure allows the determination of zeranol and/or its main metabolite zearalanone between 100 and 1000 pg.

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Zearalanol Metabolism in Steers

Cited by 32 publications

References 0 publications

Effect of rainfall timing and tillage on the transport of steroid hormones in runoff from manure amended row crop fields

Effect of rainfall timing and tillage on the transport of steroid hormones in runoff from manure amended row crop fields

Effect of Subcutaneous Implants of Zeranol on Weight Gains of Castrated Cattle at Pasture†

Radioimmunoassay of the anabolic agent zeranol I. Preparation and properties of a specific antibody to zeranol

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