ZBTB7A (zinc finger and BTB domain containing 7A)

Abstract

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Pokemon proto‐oncogene in oral cancer: potential role in the early phase of tumorigenesis

“…Pokemon gene maps on 19p13.3 and codes for a 61.5‐kDa protein (584 amino acids), which is constitutively localized in the nucleus of cells of different tissues (Pessler et al , ; Davies et al , ; Apostolopoulou et al , ). The mouse and rat homologs of Pokemon are LRF (leukemia/lymphoma related factor) and OCZF (osteoclast‐derived zinc finger), respectively, and function as transcriptional repressors involved in cellular events such as chondrogenesis, adipogenesis, and osteoclastogenesis (Jeon et al , ).…”

“…POK proteins contain a highly conserved N‐terminal domain of about 120 amino acids defined POZ (poxvirus and zinc finger) domain and a repetition of multiple Cys2His2 Krüppel‐type zinc fingers at the C‐terminus. The POZ domain mediates the homo‐ and heterodimerization of POK proteins as well as the binding and recruiting of transcriptional corepressors at gene promoter sequences (Klug and Schwabe, ; Davies et al , ; Kelly and Daniel, ; Stogios et al , ; Apostolopoulou et al , ).…”