Abstract:14Members of the broad complex, tram track, bric-a-brac and zinc finger (BTB-ZF) 15 family of transcription factors, such as BCL-6, ZBTB20, and ZBTB32, regulate antigen-16 specific B cell differentiation, plasma cell longevity, and the duration of antibody 17 production. We found that ZBTB38, a different member of the BTB-ZF family that binds 18 methylated DNA at CpG motifs, is highly expressed by germinal center B cells and 19 plasma cells. To define the functional role of ZBTB38 in B cell responses, we gener… Show more
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