Zaragozic acids production from discomycetes

Hosoya, Tsuyoshi; Tanimoto, Tatsuo; Onodera, Kaori; Kurihara, Yuko; Takamatsu, Yasuyuki; Tsujita, Yasuyuki

doi:10.1007/bf02464088

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…Anke (1993, 1995) were among the pioneers in utilizing Helotiales and discovered a series of chlorinated metabolites. Our attempts succeeded in the discovery of various enzyme inhibitors, such as squalene synthase (Hosoya et al, 1997;, sphingomyelinase (Tanaka, Nara, Suzuki-Kongai, Hosoya, & Ogita, 1997;Nara, Tanaka, Hosoya, Suzuki-Konagai, & Ogita, 1999), sphigosine kinase (Kono, Tanaka, Ogita, Hosoya, & Kohama, 2000;Kono et al, 2001), testosterone reductase , antibacterials (Matsumoto, Hosoya, & Shigemori, 2010;Matsumoto, Hosoya, Tomoda, Shiro, & Shigemori, 2011;Tanabe et al, 2015;Kawashima, Hosoya, Tomoda, Kita, & Shigemori, 2018), plant growth regulation factors (Tanabe, Matsumoto, Hosoya, Sato, & Shigemori, 2013), and antifungals (Ohyama et al, 2002).…”

Section: Discovery Researchmentioning

confidence: 99%

“… Otani (1989) enumerated the Japanese mycobiota of Discomycetes , a taxon no longer used but still practical in the modern taxonomy, and enumerated 77 genera with 214 species in the order. Through our exploration and enumeration, we added 57 newly documented taxa in Japan, and 30 new taxa, including 2 genera ( Otani, Hosoya, & Furuya, 1991 ; Hosoya et al, 1993 ; Kubono & Hosoya, 1994 ; Hosoya & Otani 1995 , 1997a , 1997b , 1997c ; Hosoya & Harada 1999 ; Hosoya, 2000 , 2002 , 2004 , 2005 , 2009 ; Ono & Hosoya, 2001 ; Tanaka & Hosoya, 2001 ; Hosoya & Huhtinen 2002 ; Narumi-Saito, Hosoya, Sano, & Harada, 2006 ; Hosoya et al, 2010a , 2010c , 2011 ; Hosoya, Sung, Han, & Shin, 2010d ; Han, Hosoya, & Shin, 2011 ; Hosoya et al, 2012 ; Hosoya, Hosaka, Saito, Degawa, & Suzuki, 2013a ; Hosoya et al, 2013b ; Hosoya, Saito, & Sasagawa, 2013c ; Zhao, Hosoya, Shirouzu, Kakishima, & Yamaoka, 2013 ; Han et al, 2014a ; Hosoya, Zhao, & Degawa, 2014 ; Zhao & Hosoya, 2014 , 2015 ; Degawa et al, 2015 ; Gross, Hosoya, Zhao, & Baral, 2015 ; Hosoya & Zhao, 2016 ; Itagaki, Nakamura, & Hosoya, 2019 ; Tochihara & Hosoya, 2019 ). These included new species, new genera of both sexual and asexual states, now being merged under single names (some examples are presented in Fig.…”

Section: Systematicsmentioning

confidence: 99%

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Systematics, ecology, and application of <i>Helotiales</i>: Recent progress and future perspectives for research with special emphasis on activities within Japan

Hosoya

2021

Mycoscience

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Helotiales is one of the most diverse groups of apothecial ascomycetes, including 3000-4000 taxa. Recent progress in the systematics, ecology, and their applications through research is herein reviewed based on the experiences of the author with a special emphasis on activities in Japan. In the past 30 y, more than 50 helotialean taxa have been added to the mycobiota of Japan, including new taxa. With the advent of molecular phylogeny, some families have been revisited, such as members with stroma (Sclerotiniaceae and Rutstroemiaceae) or hairs (Hyaloscyphaceae and Lachnaceae). Although the monophyly of Helotiales has not yet been demonstrated, our understanding of its phylogeny has greatly advanced. The unexpected ecological nature represented by endophytism has been revealed through barcoding and other molecular techniques. The research history of ash dieback is also reviewed, and the endophytism/saprophytism of the pathogen on its original host is discussed. Drug discoveries within Helotiales are reviewed, and successful examples are presented. As future perspectives, both the cumulation of occurrence and sequence data of Helotiales is greatly encouraged to elucidate this important group of fungi.

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Section: Discovery Researchmentioning

confidence: 99%

Section: Systematicsmentioning

confidence: 99%

Systematics, ecology, and application of <i>Helotiales</i>: Recent progress and future perspectives for research with special emphasis on activities within Japan

Hosoya

2021

Mycoscience

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“…Pneumocandins, taxol, and zaragonic acids, which are known to be useful bioactive compounds, are isolated from plant pathogenic fungi and endophytes (Hosoya et al, 1997;Schwartz et al, 1992;Strobel et al, 1996). As a result, it was shown that plant-inhabiting fungi are useful biological resources in the exploratory search for secondary metabolites.…”

Section: Introductionmentioning

confidence: 99%

Notes on new and noteworthy plant-inhabiting fungi from Japan (1)

Ono¹,

Kobayashi²

2001

Mycoscience

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Six fungi isolated from plant materials in Japan are described. The first is Pseudohalonectria aomoriensis sp. nov. (Lasiosphaeriaceae). It differs from other known species of the genus Pseudohalonectria in the dimensions of its asci and ascospores. The second, Monodictys abuensis, is newly added to the mycoflora of Japan. Its host, Zelkova serrata, is also newly recorded. Three others found on new host plants are Dictyochaeta simplex on Quercus myrsinaefolia and Bladhia crispa, Colletotrichum dematium on Aucuba japonica var. borealis, and Nectria mammoidea var. rubi on Cercidiphyllum japonicum. The sixth, Trochophora fasciculata, a Daphniphyllum sooty leaf spot fungus renamed by Goos from T. simplex, is reported with a full list of synonyms. Key WordsCo//etotrichum demat/um; Dictyochaeta simplex; Monodictys abuensis; Nectr/a mammoidea var. rubi; Pseudoha/onectria aomoriensis; taxonomy; Trochophora fascicu/ata.Exploratory research of secondary metabolites has long been dependent on soil fungi. Recently, many kinds of sources other than soil are being used for fungal screening (Bergstrom et al., 1995). Attention is also being paid to plant-inhabiting fungi as a complementary source to soil fungi. Plant-inhabiting fungi have been thoroughly investigated in terms of their biology and pathology, but not for their use in the exploratory search of secondary metabolites. Therefore, we started to collect plantinhabiting fungi.Plant-inhabiting fungi are categorized as plant pathogenic fungi, endophytes and saprophytes. Pneumocandins, taxol, and zaragonic acids, which are known to be useful bioactive compounds, are isolated from plant pathogenic fungi and endophytes (Hosoya et al., 1997;Schwartz et al., 1992;Strobel et al., 1996). As a result, it was shown that plant-inhabiting fungi are useful biological resources in the exploratory search for secondary metabolites. In our study, plant pathogenic fungi and endophytes were mainly collected.Presently, more than 10,000 species of fungi are reported to be associated with various diseases in plants ( Agrios, 1997). Although more than 4,000 plant pathogenic fungi in Japan are listed in "Common names of plant diseases in Japan" (Anonymous, 2000), more fungi have yet to be reported. In our search for producers of useful bioactive compounds, we sometimes encountered new or noteworthy plant-inhabiting fungi. This paper describes six such species. Material and MethodsPlant materials with apparent symptoms were collected from Aomori, Ibaraki, Shizuoka and Shimane. Whenever sporulation was observed on the specimens, spores were isolated immediately. When no sporulation was observed on the specimens, specimens were incubated in moist chambers at 15~ to induce sporulation. Singlespore isolates were obtained using a Skerman's micromanipulator (Skerman, 1968).Single spore isolates were kept on potato dextrose agar (PDA; Nissui, Tokyo) slants as a stock culture.Both dried and fresh specimens were examined for morphology. For Nectria mammoidea var. rubi and Pseudohalonectria aomoriensis, co...

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“…Several new bioactive substances, including scyphostatin [1] and F-10863s [2,3], which have enzyme inhibition activity, have been isolated from fungi of the order Leotiales (Discomycetes). Nevertheless, the members of it have been underutilized for microbial screening [4].…”

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confidence: 99%

Three New Chlorinated Cyclopentenols, Palmaenols A and B and Palmaetriol, from the Discomycete Lachnum palmae

Tanabe

Matsumoto

Hosoya

et al. 2015

Natural Product Communications

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The new chlorinated cyclopentenols, palmaenol A (1) and palmaetriol (3), were isolated from the culture broth of the discomycete Lachnum palmae (NBRC-106495). In addition, a new chlorinated cyclopentenol, palmaenol B (2), a geometric isomer of 1, was also obtained from the culture broth containing KCl. The structures of 1-3 were elucidated from spectroscopic data. Compounds 1-3 are cyclopentenols containing three or two chlorines; 1 and 2 are also reduced forms of palmaenones A (4) and B (5), which have been isolated from the same discomycete, respectively. Compounds 4 and 5 had potent antimicrobial activity, while compounds 1-3 showed no such activity. Thus, it is suggested that the unsaturated carbonyl group at C-6 has an important role for the antimicrobial activity.

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Zaragozic acids production from discomycetes

Cited by 10 publications

References 14 publications

Systematics, ecology, and application of <i>Helotiales</i>: Recent progress and future perspectives for research with special emphasis on activities within Japan

Systematics, ecology, and application of <i>Helotiales</i>: Recent progress and future perspectives for research with special emphasis on activities within Japan

Notes on new and noteworthy plant-inhabiting fungi from Japan (1)

Three New Chlorinated Cyclopentenols, Palmaenols A and B and Palmaetriol, from the Discomycete Lachnum palmae

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