Zao Ren An Shen for insomnia: a systematic review with meta-analysis

Birling, Yoann; Jia, Mingxian; Li, Guixia; Sarris, Jerome; Bensoussan, Alan; Zhu, Xiaoshu

doi:10.1016/j.sleep.2019.12.023

Cited by 19 publications

(33 citation statements)

References 73 publications

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“…It is commonly used as an outcome in clinical trials and meta-analyses of TCM. [ 7 13 14 ] In GCTNPCM, [17] evaluation standards for clinical therapeutic effects were as follows:…”

Section: Methodsmentioning

confidence: 99%

“… [6] CBT is largely unavailable to people with insomnia though it is considered as first-line treatment for adults with chronic insomnia disorder. [7] Due to the above shortcomings, it is necessary to explore better treatment. There have been many randomized-controlled trials (RCTs) evaluating the efficacy of complementary and alternative medicine (CAM) because of the significant health risks associated with insomnia.…”

Section: Introductionmentioning

confidence: 99%

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Chaihu Longgu Muli decoction, a Chinese herbal formula, for the treatment of insomnia

Wang

et al. 2020

Medicine

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Purpose: To review the literature on the efficacy and safety of Chaihu Longgu Muli decoction (CLMD) for insomnia. Methods: A systematic literature search was performed for five databases up to May of 2019 to identify randomized control trials involving CLMD for patients with insomnia. The experimental group was CLMD monotherapy or CLMD plus conventional treatment. Comparators were placebo, no treatment, or conventional medicine. The main comparison was CLMD against conventional drugs. The primary outcome was sleep quality (assessed using the Pittsburgh Sleep Quality Index, PSQI). The secondary outcomes were clinical effectiveness rate, total sleep time, and adverse event rate. RevMan 5.3 software was used for meta-analysis with effect estimate presented as relative risk (RR) and mean difference (MD) with 95% confidence interval (CI). Results: A total of 22 studies involving 2029 patients were included. All the included studies presented some risk of bias, especially risks of performance, and detection bias. The main meta-analysis showed that CLMD alone was more effective than conventional medications by reducing PSQI (MD = −2.80, 95% CI [−5.48, −0.13], P = .04), improving the clinical effectiveness rate (RR = 1.23, 95% CI [1.16, 1.31], P < .00001), and prolonging total sleep time (MD = 1.01, 95% CI [0.19, 1.83], P = .002). The adverse event rate in the CLMD group was lower than that of the control group (RR = 0.22, 95% CI [0.09, 0.51], P = .0005). CLMD also improved sleep quality better than conventional medications as an adjunct therapy ( P < .05). The funnel plot was symmetrical, representing a low risk of publication bias. Conclusion: CLMD presented better efficacy and safety than conventional medications and had the potential to become an alternative to conventional medications for the treatment of insomnia. However, as the included studies showed significant risks of bias, these results will need to be confirmed by future double-blind randomized controlled trials. PROSPERO registration number: CRD42019133103.

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“…It is commonly used as an outcome in clinical trials and meta-analyses of TCM. [ 7 13 14 ] In GCTNPCM, [17] evaluation standards for clinical therapeutic effects were as follows:…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chaihu Longgu Muli decoction, a Chinese herbal formula, for the treatment of insomnia

Wang

et al. 2020

Medicine

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“…Chinese medicinal herbs and formulas have been extensively utilized in the treatment of insomnia for more than 2000 years with the advantages of economic, high e cacy, easy access, and good population basis [24]. Previous studies have found that when used as a monotherapy or an adjunct to conventional therapies, Chinese herbal medicine has shown signi cant improvements in different aspects of sleep in insomniacs [25][26][27].Based on clinical symptoms and signs collected through inspection, auscultation, olfaction, interrogation, and pulse palpation, TCM syndromes were nally determined on which the clinicians based to choose suitable treatments. According to the theory of TCM, the liver is responsible for blood storage and catharsis.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Qinggan Jieyu Herbal Formula Granule on Insomnia: A Prospective Randomized Controlled Trial

Han¹,

Feng²,

Cao³

et al. 2021

Preprint

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Background:Traditional Chinese Medicine (TCM) is widely used in China for insomnia treatment. The objective of this study was to evaluate the efficacy and safety of QingganJieyu (QGJY)Herbal Formula Granule for insomnia patients with liver depression of heat syndrome.Methods: In this randomized controlled clinical trial, 60patients were randomly assigned into the treatment group and the control group in a 1:1 ratio. Participants received QGJYHerbal Formula GranuleandWuling capsulerespectively for 4 weeksand were followed for another 4 weeks. The primary outcomes weresyndrome integral changes according to theliver depression of heat syndrome evaluation scaleand global and subscale score changes according to the Pittsburgh Sleep Quality Index (PSQI). The secondary outcome wasquality of life assessed by the Short-form 36 Questionnaire (SF-36). A correlation analysis was also done between syndrome integral and PSQI global score and subscale score. Results: Compared with pretreatment baseline, patients in both groups showed a decreasedtrend in TCM syndrome integral scores, especially for the main syndrome.There were significant differences in the total score of syndrome integral between the two groups at 2, 3, 4 weeks, and follow-up period (all Ps<0.05)).During the treatment period, patients in both groups experienced a lower trend and the differences in PSQI global score, sleep disturbance, sleep duration, and use of sleep medication between the two groups were statistically significant (all Ps<0.05).Concerning secondary outcome measure, quality of life was improved for patients in both groups and mental health on the SF-36 questionnaire improvement was significantly better for the treatment group (P<0.05). Additionally, a significant, positive correlation was found between sleep disorders and TCM syndrome integral change (Pearson r = 0.340, P < 0.001).Conclusions:Results of our study suggested that QGJY Herbal Formula Granule not only improved the liver depression of heat syndrome(syndrome) but also sleep disturbance, sleep duration, and use of sleep medication(disease). Additionally, QGJY Herbal Formula Granule promotes psychological health better. Considering therelationship between insomnia and adverse mental health, our findings may have important implications for the management of insomnia in the long run.Trial registration:ChiCTR, ChiCTR-TRC-14004469, Registered 24 January 2014- Retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=5101.

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“…Insomnia is a common public health problem, affecting about 40% to 50% of the general population, [ 1 ] and its prevalence is increasing. [ 2 ] In the United States, it is estimated that one-third of adults are experiencing insomnia.…”

Section: Introductionmentioning

confidence: 99%

Suan-Zao-Ren decoction for insomnia

Song

Fan²,

Zhang³

et al. 2020

Medicine

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Background: Chinese herbal medicine has been widely used to relieve insomnia. Among them, Suan-Zao-Ren decoction (SZRD) has a significant effect in alleviating insomnia. The purpose of this systematic review is to evaluate the effectiveness and safety of SZRD in treating insomnia. Methods: Relevant randomized controlled trials (RCTs) will be searched from the databases of Embase, PubMed, the Cochrane Library, the China National Knowledge Infrastructure, Wanfang Database and Chinese Science and Technology Periodical Database from their inception to July 2020. Two independent reviewers will select studies, collect data, and assess the methodology quality by the Cochrane risk of bias tool. Statistical analysis is processed by RevMan V.5.3 software. Results: The results of this systematic review will provide an assessment of SZRD treatment of insomnia, and aims to prove the effectiveness and safety of SZRD. Conclusion: This study will provide a credible Evidence-based for the treatment of Insomnia with SZRD.

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Zao Ren An Shen for insomnia: a systematic review with meta-analysis

Cited by 19 publications

References 73 publications

Chaihu Longgu Muli decoction, a Chinese herbal formula, for the treatment of insomnia

Chaihu Longgu Muli decoction, a Chinese herbal formula, for the treatment of insomnia

Efficacy and Safety of Qinggan Jieyu Herbal Formula Granule on Insomnia: A Prospective Randomized Controlled Trial

Suan-Zao-Ren decoction for insomnia

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