Zanthoxylum chiloperone leaves extract: First sustainable Chagas disease treatment

Ferreira, Marı́a Elena; Cebrián‐Torrejón, Gerardo; Corrales, Alba Segovia; Bilbao, Ninfa Vera de; Rolón, Míriam; Gómez, Celeste Vega; Leblanc, Karine; Yaluf, Gloria; Schinini, Alicia; Torres, Susana; Serna, Elva; Arias, Antonieta Rojas de; Poupon, Erwan; Fournet, Alain

doi:10.1016/j.jep.2010.11.032

Cited by 41 publications

(45 citation statements)

References 25 publications

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“…In the current report, we describe the application of the VMP methodology for monitoring the presence of different metabolites directly in several parts of the plants of Zanthoxylum chiloperone , namely, canthin‐6‐one ( L1 ), 5‐methoxycanthin‐6‐one ( L2 ) and avicennol ( L3 ), as well as in the alcoholic extracts from them, these results are validated with HPLC data already published by our group (Ferreira et al ). In order to assess the suitability of the proposed methodology for in field studies, experiments were also performed with portable equipment using no‐deaerated phosphate buffer solutions.…”

Section: Introductionsupporting

confidence: 70%

Phytoelectrochemical analysis of Zanthoxylum chiloperone

Cebrián‐Torrejón

Doménech‐Carbó

Figadère

et al. 2016

Phytochemical Analysis

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Section: Introductionsupporting

confidence: 70%

Phytoelectrochemical analysis of Zanthoxylum chiloperone

Cebrián‐Torrejón

Doménech‐Carbó

Figadère

et al. 2016

Phytochemical Analysis

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“…A decoction of Z. chiloperone root and stem bark has been used in traditional medicine to treat malaria and for its emmenagogue and antirheumatic properties (Ferreira et al, 2007;Milliken, 1997). Recent studies have shown that the crude extract of the stem bark and leaves have activity against Trypanosoma cruzi (Ferreira et al, 2011;Ferreira et al, 2002) and antifungal activity in vitro (Thouvenel et al, 2003). Further investigations demonstrate that canthinone type alkaloids, canthin-6-one and 5-methoxycanthin-6-one, are antifungal (Soriano-Agatόn et al, 2005;Thouvenel et al, 2003) and effective in vivo against Leishmania amazonensis and Trypanosoma cruzi (Ferreira et al, 2011;Ferreira et al, 2007;Ferreira et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have shown that the crude extract of the stem bark and leaves have activity against Trypanosoma cruzi (Ferreira et al, 2011;Ferreira et al, 2002) and antifungal activity in vitro (Thouvenel et al, 2003). Further investigations demonstrate that canthinone type alkaloids, canthin-6-one and 5-methoxycanthin-6-one, are antifungal (Soriano-Agatόn et al, 2005;Thouvenel et al, 2003) and effective in vivo against Leishmania amazonensis and Trypanosoma cruzi (Ferreira et al, 2011;Ferreira et al, 2007;Ferreira et al, 2002). Canthin-6-one has been suggested to be an inexpensive and safe treatment for use in long-term oral treatment as well as a good candidate against drug resistant strains of T. cruzi.…”

Section: Introductionmentioning

confidence: 99%

The antiplasmodium effects of a traditional South American remedy: Zanthoxylum chiloperone var. angustifolium against chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparum

Cebrián‐Torrejón¹,

Spelman

Leblanc³

et al. 2011

Rev. bras. farmacogn.

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Zanthoxylum chiloperone var. angustifolium Engl., Rutaceae, is used in traditional medicine to treat fungal and protozoal infections in the central area of South America. Considering the increasing resistance of Plasmodium falciparum in malarial ridden areas, we explored the anti-plasmodial effects of three compounds isolated from Z. chiloperone. The pyranocoumarin transavicennol and the canthinone alkaloids, canthin-6-one and 5-methoxycanthin-6-one, were found to have IC50 on chloroquine/mefloquine resistant and sensitive strains of P. falciparum of 0.5-2.7, 2.0-5.3 and 5.1-10.4 μg/mL, respectively. Moreover, the formation of heme adducts by these compounds is described by a novel alternative method based on MS-CID methods. The alkylamide sanshool was also identified, for first time in this plant, in the dichloromethanic and ethanolic extracts and the extracts were found to be notably non-toxic and displayed good anti-plasmodial effects.

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“…Los aceites esenciales de Achillea millefolium L (milenrama), Syzygium aromaticum L (clavo) y Ocimun basilicum L (albahaca) también han demostrado su actividad inhibitoria del desarrollo de epimastigotes y tripomastigotes de T. cruzi (22) . Recientemente se ha informado la eficacia in vitro del extracto etanólico de hojas de Zanthoxylum chiloperone y de la canthin-6-ona, principal componente de la corteza del tallo y la raíz, contra las formas tripomastigotes y amastigotes de T. cruzi, así como la eficacia del extracto etanólico de las hojas en la reducción de la parasitemia por T. cruzi en ratones Balb/c (23) . Por otra parte, el derivado fenólico de un alcaloide naftilisoquinolínico aislado de Ancistrocladus cochinchinensis mostró excelente actividad contra T. cruzi (24) .…”

Section: Discussionunclassified

Efecto del aceite esencial de Aloysia triphylla britton (cedrón) sobre el Trypanosoma cruzi en ratones

Rojas

Palacios

Ronceros

2014

Rev Peru Med Exp Salud Publica

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RESUMENObjetivos. Determinar la actividad anti-Trypanosoma cruzi in vivo del aceite esencial de Aloysia triphylla en ratones. Materiales y Métodos. Los animales fueron asignados aleatoriamente a los siguientes grupos (n = 15 por grupo): infectados y no tratados (G1), infectados y tratados con benznidazol 100 mg/kg (G2), infectados y tratados con aceite esencial de Aloysia triphylla 100 mg/kg (G3), infectados y tratados con aceite esencial de Aloysia triphylla 250 mg/kg (G4); no infectados y no tratados (G5), y no infectados y tratados con 250 mg/kg de Aloysia triphyla (G6). La infección con T. cruzi se realizó con 10 4 tripomastigotes sanguíneos y el tratamiento empezó en el octavo día postinfección (dpi) hasta el 28 dpi. La parasitemia se determinó con microscopía óptica cada dos días en 5 µL de sangre extraída de la cola. En el 14, 21 y 28 dpi se obtuvo sangre de la cola para el ensayo de creatina kinasa-MB (CK-MB), alanina aminotransferasa y creatinina; después, los animales fueron sacrificados y se extrajo el corazón para el estudio histopatológico. Resultados. El aceite esencial de cedrón produjo una reducción significativa de 85,4% del pico de parasitemia con la dosis de 250 mg/kg; también produjo reducción del número de amastigotes e infiltrados inflamatorios en el corazón. El nivel plasmático de CK-MB también disminuyó en el 28 dpi por efecto de dicho tratamiento. Conclusiones. En condiciones experimentales, el aceite esencial de Aloysia triphylla tiene efecto anti-Trypanosoma cruzi in vivo en ratones. Palabras clave: Trypanosoma cruzi; Cedrón; Aceites esenciales; Experimentación animal (fuente: DeCS BIREME). THE EFFECT OF THE ESSENTIAL OIL FROM Aloysia triphylla BRITTON (LEMON VERBENA) ON Trypanosoma cruzi IN MICE ABSTRACTObjectives. To determine the in-vivo anti-Trypanosoma cruzi activity of the essential oil from Aloysia triphylla in mice. Materials and methods. The mice (n = 15) in the study were randomly assigned to the following groups: infected and untreated (G1), infected and treated with benznidazole 100 mg/kg (G2), infected and treated with of Aloysia triphylla essential oil 100 mg/kg (G3), infected and treated with of Aloysia triphylla essential oil 250 mg/kg (G4), uninfected and untreated (G5), and uninfected and treated with 250 mg/kg of Aloysia triphyla (G6). The infection was conducted using 104 blood T. cruzi trypomastigotes and the treatment began on the 8th day post-infection (dpi) through 28 dpi. The parasitemia was determined through optical microscopy every 2 days using 5 µL of blood sampled from the tail. In dpi 14, 21 and 28, the blood sample was obtained from the queue for testing creatine kinase-MB, alanine aminotransferase and creatinine, then animals were euthanized and the heart was removed for histopathological study. Results. The essential oil of lemon verbena produced a significant reduction of the parasitemia, 85.4% with the peak at a the dose of 250 mg/ kg. It was also observed a reduction in the number of amastigotes and inflammatory infiltrates in the heart. The creatin...

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Zanthoxylum chiloperone leaves extract: First sustainable Chagas disease treatment

Cited by 41 publications

References 25 publications

Phytoelectrochemical analysis of Zanthoxylum chiloperone

Phytoelectrochemical analysis of Zanthoxylum chiloperone

The antiplasmodium effects of a traditional South American remedy: Zanthoxylum chiloperone var. angustifolium against chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparum

Efecto del aceite esencial de Aloysia triphylla britton (cedrón) sobre el Trypanosoma cruzi en ratones

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