Zaltoprofen-layered double hydroxide hybrids to enhance zaltoprofen solubility and dissolution rate

Maggi, Lauretta; Bruni, Giovanna; Ferrara, Chiara; Puscalau, Constantin; Quinzeni, Irene; Friuli, Valeria; Monteforte, Francesco; Capsoni, Doretta

doi:10.1016/j.clay.2022.106723

Cited by 6 publications

(6 citation statements)

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“…Maggi's group slightly modified HNTs by subjecting them to etching with substances like HCl, H 2 SO 4 , and NaOH. [146] Their findings highlighted that HNTs etched with HCl (8 m) exhibited superior dissolution rates, wettability, and solubility when loaded with carvedilol. Moeinpour and colleagues similarly explored HNT etching, [145] revealing that etching could enhance the loading capacity of HNTs for losartan, while calcination had the opposite effect.…”

Section: Halloysite Nanotubes For Hypertensionmentioning

confidence: 99%

“…Yendluri's research team delved into nifedipine delivery using pristine HNTs. [144] They achieved noteworthy results, as loading nifedipine at 7.4 wt% within HNTs led to nearly zero-order Yendluri [ 144] Nifedipine / Pristine HNT No further modification Moeinpour [ 145] Losartan Sustained release; E-HNT or C-HNT HNT is etched with sulfuric acid and produced E-HNT; HNT heated to 400 °C and produce C-HNT Maggi [ 146] Carvedilol ↑Solubility; ↑Dissolution rate E-HNT HNT etched with different types of HCl, H 2 SO 4 , and NaOH.…”

Section: Halloysite Nanotubes For Hypertensionmentioning

confidence: 99%

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Recent Advances of Halloysite Nanotubes in Biomedical Applications

Jiang,

Sun,

Liu

et al. 2023

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Halloysite nanotubes (HNTs) have emerged as a highly regarded choice in biomedical research due to their exceptional attributes, including superior loading capacity, customizable surface characteristics, and excellent biocompatibility. HNTs feature tubular structures comprising alumina and silica layers, endowing them with a large surface area and versatile surface chemistries that facilitate selective modifications. Moreover, their substantial pore volume and wide range of pore sizes enable efficient entrapment of diverse functional molecules. This comprehensive review highlights the broad biomedical application spectrum of HNTs, shedding light on their potential as innovative and effective therapeutic agents across various diseases. It emphasizes the necessity of optimizing drug delivery techniques, developing targeted delivery systems, rigorously evaluating biocompatibility and safety through preclinical and clinical investigations, exploring combination therapies, and advancing scientific understanding. With further advancements, HNTs hold the promise to revolutionize the pharmaceutical industry, opening new avenues for the development of transformative treatments.

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Section: Halloysite Nanotubes For Hypertensionmentioning

confidence: 99%

Section: Halloysite Nanotubes For Hypertensionmentioning

confidence: 99%

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Jiang,

Sun,

Liu

et al. 2023

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“…For example, LDHs can intercalate bioactive species establishing arrangements and physical interactions that favor solubilization compared to those ones in the pristine drug crystal. Many drugs, such as the anti-inflammatories ibuprofen [ 202 ] and zaltoprofen [ 203 ], the diuretic piretanide [ 204 ], and the vitamin B3 (nicotinic acid) [ 205 ], among others, were manipulated by intercalation into LDH to overcome the low solubility challenge. The solubility test of zaltoprofen in water and phosphate buffer (pH equal to 6.8) showed that its intercalation into Zn R Al-LDH improved three times its solubility compared to the non-intercalated drug [ 203 ] and presented better performance than the physical mixture of zaltoprofen and LDH, demonstrating the benefits of the DDS approach.…”

Section: Drug Delivery Systems Based On Organic Polymers and Layered ...mentioning

confidence: 99%

Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

et al. 2023

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The development of biomaterials has a substantial role in pharmaceutical and medical strategies for the enhancement of life quality. This review work focused on versatile biomaterials based on nanocomposites comprising organic polymers and a class of layered inorganic nanoparticles, aiming for drug delivery (oral, transdermal, and ocular delivery) and tissue engineering (skin and bone therapies). Layered double hydroxides (LDHs) are 2D nanomaterials that can intercalate anionic bioactive species between the layers. The layers can hold metal cations that confer intrinsic biological activity to LDHs as well as biocompatibility. The intercalation of bioactive species between the layers allows the formation of drug delivery systems with elevated loading capacity and modified release profiles promoted by ion exchange and/or solubilization. The capacity of tissue integration, antigenicity, and stimulation of collagen formation, among other beneficial characteristics of LDH, have been observed by in vivo assays. The association between the properties of biocompatible polymers and LDH-drug nanohybrids produces multifunctional nanocomposites compatible with living matter. Such nanocomposites are stimuli-responsive, show appropriate mechanical properties, and can be prepared by creative methods that allow a fine-tuning of drug release. They are processed in the end form of films, beads, gels, monoliths etc., to reach orientated therapeutic applications. Several studies attest to the higher performance of polymer/LDH-drug nanocomposite compared to the LDH-drug hybrid or the free drug.

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“…The applications include adsorbent materials, magnetic materials, biomedical functionality, hybrid materials, environmental remediation, catalysts, ion exchange processes, supercapacitors, sensors, water treatment, and CO 2 gas removal. 18,19,[24][25][26][27][28][29][30][31][32][33][34][35] LDH exhibits significant promise for low-temperature CO 2 capture due to its rapid adsorption and desorption rate, good cyclic stability, and high selectivity towards CO 2 . 36,37 Although LDH has exhibited favorable attributes, most LDH studied thus far have had a limitation in their ability to adsorb CO 2 .…”

Section: Introductionmentioning

confidence: 99%

“…The unique structure of LDH demonstrates a wide range of potential uses, including its use as a composite material with several functional capabilities. The applications include adsorbent materials, magnetic materials, biomedical functionality, hybrid materials, environmental remediation, catalysts, ion exchange processes, supercapacitors, sensors, water treatment, and CO 2 gas removal 18,19,24–35 . LDH exhibits significant promise for low‐temperature CO 2 capture due to its rapid adsorption and desorption rate, good cyclic stability, and high selectivity towards CO 2 36,37 …”

Section: Introductionmentioning

confidence: 99%

Fabrication of new in‐situ ternary nano/microcomposite LDH/Ag₂O/Bayerite in trimetallic NiAg/Al layered double hydroxides for CO₂ capture material

Wihadi

2024

Greenhouse Gases

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We reported new in‐situ ternary nano/microcomposite layered double hydroxides/Ag2O/bayerite in trimetallic NiAg/Al layered double hydroxides (LDH) via hydrothermal technique; and characterization by powder X‐ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT‐IR), field emission scanning electron microscopy (FE‐SEM), energy dispersive spectroscopy (EDS), and N2 adsorption‐desorption. The formation of bayerite and silver oxide species on the LDH nanosheet depended on the excess of Al3+ and Ag+ in the solution under alkaline and hydrothermal conditions. The nitrogen isotherm adsorption profile for all ternary composites exhibited uniformity with mesoporous and lamellar characteristics. The surface area of all the composites ranged from 81.17 to 150.23 m2. g−1, the Barret‐Joyner‐Halenda (BJH) pore volume from 0.22 to 0.27 cm3. g−1, and the average pore diameter ranged from 3.47 to 5.78 nm. All composites show a laminar plate‐like structure covered with elongated pieces. The particle size of the composites ranged from 54.86 to 115.96 nm, indicating the size changed from nano to microcomposite because of the different molar ratios of Ag and Ni in the solid. The ternary composite reveals CO2 capture activity with adsorption capacity ranging from 13.93 to 19.61 mmol g−1. © 2024 Society of Chemical Industry and John Wiley & Sons, Ltd.

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Zaltoprofen-layered double hydroxide hybrids to enhance zaltoprofen solubility and dissolution rate

Cited by 6 publications

References 50 publications

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

Fabrication of new in‐situ ternary nano/microcomposite LDH/Ag₂O/Bayerite in trimetallic NiAg/Al layered double hydroxides for CO₂ capture material

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Zaltoprofen-layered double hydroxide hybrids to enhance zaltoprofen solubility and dissolution rate

Cited by 6 publications

References 50 publications

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

Fabrication of new in‐situ ternary nano/microcomposite LDH/Ag2O/Bayerite in trimetallic NiAg/Al layered double hydroxides for CO2 capture material

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Product

Resources

About

Fabrication of new in‐situ ternary nano/microcomposite LDH/Ag₂O/Bayerite in trimetallic NiAg/Al layered double hydroxides for CO₂ capture material