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Niederman, Michael S.

doi:10.1186/cc1038

Cited by 8 publications

(1 citation statement)

References 10 publications

(13 reference statements)

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“…VAP is considered the most common nosocomial infection in the intensive care unit (ICU), with an incidence that varies between 9% and 27% depending on the population, type of ICU, and diagnostic criteria applied [2,3]. VAP prolongs the hospitalization stay and need for mechanical ventilation, which considerably increases costs [4,5]. VAP-associated mortality rates vary between 20% and 70%, and are even higher when caused by multiresistant pathogens or when inadequate antibiotic therapy is used [6,7].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and outcomes of ventilator-associated pneumonia in northern Brazil: an analytical descriptive prospective cohort study

et al. 2013

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BackgroundVentilator-associated pneumonia (VAP) is considered the most common nosocomial infection in the intensive care unit (ICU), but its features are not fully known in many hospitals in Brazil. We identified clinical and epidemiological aspects associated with VAP in an intensive care unit (ICU) in a general public hospital in northern Brazil and performed an analytical descriptive prospective cohort study.MethodsWe analyzed data from thirty-three patients who developed VAP while in the ICU. Clinical and epidemiological data of patients were obtained and tracheal secretions were submitted to culture. Microbial isolates were identified and evaluated for resistance against antimicrobial agents by using the automated Vitek 2 system.ResultsThe frequency of VAP was 26.2% in patients submitted to invasive mechanical ventilation for at least 48 hours, and death occurred in 78.8% of cases. Only the presence of comorbidity showed a significant association (P = 0.029) with death. The most commonly found bacteria were Pseudomonas aeruginosa, Acinetobacter spp., and Enterobacteriaceae. We also found a frequency of 54.5% of multiresistant bacteria associated with VAP, and previous antibiotic therapy was used in 97% of patients.ConclusionsVAP in our ICU presented with a high frequency and was mainly caused by multiresistant bacteria. Implementation of rational protocols for the use of antibacterial agents and rapid delivery of culture and susceptibility test results are essential. This may help decrease VAP-related mortality rates by multiresistant bacteria in the ICU.

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