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Boerma, E. Christiaan; Mathura, Keshen R.; Voort, Peter H. J. van der; Spronk, Peter E.; İnce, Can

doi:10.1186/cc3809

Cited by 266 publications

(104 citation statements)

References 19 publications

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“…MFI is the sum of these flow scores divided by the number of quadrants in which the vessel type is visible. The intraobserver agreement κ score of MFI is 0.78 and 0.95 and interobserver agreement between 0.77 and 1 [18,20,22]. For each time point and each patient, the scores for MFI were averaged.…”

Section: Methodsmentioning

confidence: 99%

“…According to the recommendations, microvascular flow index (MFI), perfused vessel density (PVD), proportion of perfused vessels (PPVs), and indices of heterogeneity were determined for every patient at all time points. All have been validated previously [18,19,20]. Each score was determined for both large and small microvessels with a cut-off diameter of 20 μm [21].…”

Section: Methodsmentioning

confidence: 99%

“…For PVD, the coefficient of variation was determined [18]. For MFI, the heterogeneity was assessed in each patient by subtracting the lowest from the highest quadrant MFI and dividing the result by the mean MFI [20]. …”

Section: Methodsmentioning

confidence: 99%

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Haemodialysis Impairs the Human Microcirculation Independent from Macrohemodynamic Parameters

Meinders

Nieuwenhuis²,

İnce³

et al. 2015

Blood Purif

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Hemodynamic changes during haemodialysis are common. Often these changes are associated with symptoms that are thought to be the result of reduced microcirculatory blood flow and oxygen delivery. The microcirculatory effect of hemodialysis is scarcely researched, though of possible influence on patient outcome. New techniques have become available to visualise and analyse microvascular blood flow. We performed an observational study using Sidestream Dark Field imaging, a microscopic technique using polarised light to visualise erythrocytes passing through sublingual capillaries, to analyse the effect of haemodyalisis on central microvascular blood flow. We showed that there is a substantial impairment of microvascular blood flow and a discrepancy between micro- and macro-vascular parameters.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Haemodialysis Impairs the Human Microcirculation Independent from Macrohemodynamic Parameters

Meinders

Nieuwenhuis²,

İnce³

et al. 2015

Blood Purif

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“…Revision surgery has shown salvage rates of potential failures of up to 80% of the reoperations [10,11]. The evidence indicates that early detection and exploration of the flap vascular compromise increases survival rates significantly [13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Noninvasive Flap Monitoring using Sidestream Dark Field Microscan: A Method for Real-Time Observation of Submilimmetric Vessels

Yáñez¹,

Rodríguez²,

Cifuentes³

et al. 2017

Anaplastology

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“…These methods can be used at wide ranges of haematocrit. Both techniques allowed clinicians to assess, at the bedside, the sublingual microcir- culation reflecting the splanchnic microcirculation, as was demonstrated by Boerma [6,21].There are some limitations regarding both methods. As the vascular wall cannot be visualized, only vessels containing RBC may be detected [18] while RBC that are not contained in vessels may disturb visualization of microvessels [22].…”

Section: Evaluation Of Microcirculationmentioning

confidence: 99%

Sepsis and septic shock – is a microcirculation a main player?

Lipińska-Gediga¹

2016

Anaesthesiol Intensive Ther

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Shock, defined at a cellular level, is a condition in which oxygen delivery to the cells is not sufficient to sustain cellular activity and support organ function. The central role of microcirculation in providing oxygen to the cells makes it of prime importance in determining organ function. In sepsis and septic shock, macrocirculatory alterations and microcirculatory dysfunction participate concurrently in the pathophysiology of organ failure. Haemodynamic coherence in shock is a condition in which normalization of systemic haemodynamic variables results in simultaneous amelioration in the perfusion of the microcirculation and restoration of tissue oxygenation as a final result. Septic shock is most frequently characterized by a lack of microcirculatory recruitment despite of macrocirculatory successful resuscitation. The lack of haemodynamic coherence between macrocirculation and microcirculation in septic patients results in treatment failure and increased mortality. The monitoring of microcirculation and the effects of its changes are an important area of future clinical research and treatment modification.

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Untitled

Cited by 266 publications

References 19 publications

Haemodialysis Impairs the Human Microcirculation Independent from Macrohemodynamic Parameters

Haemodialysis Impairs the Human Microcirculation Independent from Macrohemodynamic Parameters

Noninvasive Flap Monitoring using Sidestream Dark Field Microscan: A Method for Real-Time Observation of Submilimmetric Vessels

Sepsis and septic shock – is a microcirculation a main player?

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