Untitled

Geurts, Petrus A.T.M.; Roosendaal, Hans E.

doi:10.1023/a:1012218321453

Cited by 7 publications

(2 citation statements)

References 11 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7,8 CLs are common in MS and typically absent or less prevalent in several MS-mimicking conditions. 7 Despite the fact that only a limited proportion of CLs can be detected in vivo in patients with MS, 9,10 the visualization of CLs can be significantly improved by using dedicated 3-dimensional (3-D) MRI sequences, including magnetization-prepared rapid gradient echo, 11 magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE), 12 double inversion recovery (DIR), 13 and phase-sensitive inversion recovery (PSIR). 14 Evidence that CLs increase the specificity of a diagnosis of MS in patients with clinically isolated syndrome (CIS) 15,16 has led to the integration of CLs with juxtacortical lesions as an additional feature to demonstrate dissemination in space in the 2017 McDonald criteria.…”

mentioning

confidence: 99%

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis

Cagol,

Cortese,

Barakovic

et al. 2024

JAMA Neurol

View full text Add to dashboard Cite

ImportanceMultiple sclerosis (MS) misdiagnosis remains an important issue in clinical practice.ObjectiveTo quantify the performance of cortical lesions (CLs) and central vein sign (CVS) in distinguishing MS from other conditions showing brain lesions on magnetic resonance imaging (MRI).Design, Setting, and ParticipantsThis was a retrospective, cross-sectional multicenter study, with clinical and MRI data acquired between January 2010 and May 2020. Centralized MRI analysis was conducted between July 2020 and December 2022 by 2 raters blinded to participants’ diagnosis. Participants were recruited from 14 European centers and from a multicenter pan-European cohort. Eligible participants had a diagnosis of MS, clinically isolated syndrome (CIS), or non-MS conditions; availability of a brain 3-T MRI scan with at least 1 sequence suitable for CL and CVS assessment; presence of T2-hyperintense white matter lesions (WMLs). A total of 1051 individuals were included with either MS/CIS (n = 599; 386 [64.4%] female; mean [SD] age, 41.5 [12.3] years) or non-MS conditions (including other neuroinflammatory disorders, cerebrovascular disease, migraine, and incidental WMLs in healthy control individuals; n = 452; 302 [66.8%] female; mean [SD] age, 49.2 [14.5] years). Five individuals were excluded due to missing clinical or demographic information (n = 3) or unclear diagnosis (n = 2).ExposuresMS/CIS vs non-MS conditions.Main Outcomes and MeasuresArea under the receiver operating characteristic curves (AUCs) were used to explore the diagnostic performance of CLs and the CVS in isolation and in combination; sensitivity, specificity, and accuracy were calculated for various cutoffs. The diagnostic importance of CLs and CVS compared to conventional MRI features (ie, presence of infratentorial, periventricular, and juxtacortical WMLs) was ranked with a random forest model.ResultsThe presence of CLs and the previously proposed 40% CVS rule had a sensitivity, specificity, and accuracy for MS of 59.0% (95% CI, 55.1-62.8), 93.6% (95% CI, 91.4-95.6), and 73.9% (95% CI, 71.6-76.3) and 78.7% (95% CI, 75.5-82.0), 86.0% (95% CI, 82.1-89.5), and 81.5% (95% CI, 78.9-83.7), respectively. The diagnostic performance of the CVS (AUC, 0.89 [95% CI, 0.86-0.91]) was superior to that of CLs (AUC, 0.77 [95% CI, 0.75-0.80]; P &lt; .001), and was increased when combining the 2 imaging markers (AUC, 0.92 [95% CI, 0.90-0.94]; P = .04); in the random forest model, both CVS and CLs outperformed the presence of infratentorial, periventricular, and juxtacortical WMLs in supporting MS differential diagnosis.Conclusions and RelevanceThe findings in this study suggest that CVS and CLs may be valuable tools to increase the accuracy of MS diagnosis.

show abstract

mentioning

confidence: 99%

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis

Cagol,

Cortese,

Barakovic

et al. 2024

JAMA Neurol

View full text Add to dashboard Cite

show abstract

“…It has been stated [4,14,15], that the driving force for this market is that authors want to publish more and have their product widely available, while readers want to read less, but want to be informed of all that is relevant for their research at hand. The readers want this information available just in time.…”

Section: The Market and Its Forcesmentioning

confidence: 99%

Developments in scientific communication: Considerations on the value chain*

Roosendaal

Geurts

Vet

2001

ISU

Self Cite

View full text Add to dashboard Cite

This article analyses the transformation of the value chain of scientific information in response to concomitant changes in scientific research and education.The scientific communication market is described in terms of main driving forces and their interplay. These forces are the actor (author/reader), accessibility, content, and applicability pairs. Scientific communication is described in this article in terms of its four functions: registration, archive, awareness, and certification.The introduction of these forces and functions allows a structural analysis of the scientific communication market and allows us to discuss aspects of structural continuity in, e.g., describing the transformation from a paper-based system to communication in a digital environment. The developments are seen to emphasise the already existing autonomous development towards a "unified archive", lead us to review certification policies to include elements external to research and lead us to consider new structures for scientific communication, and publications.The new structures can be seen to result from the interactions in the market as modelled by the forces and the functions. The distinction between formal and informal communication is seen to become less useful. The need to review the structure and organisation of the market becomes evident, in particular if we consider communication during research and education as well.This leads us to speculate whether elements of the virtual organisation are of relevance.

show abstract

References

2010

Scientific Publishing

View full text Add to dashboard Cite

Untitled

Cited by 7 publications

References 11 publications

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis

Developments in scientific communication: Considerations on the value chain*

References

Contact Info

Product

Resources

About