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Mirkin, Sebastián; Gimeno, Trinidad García; Bovea, Carmina; Stadtmauer, Laurel; Gibbons, William E.; Oehninger, Sergio

doi:10.1023/a:1026236726568

Cited by 37 publications

(8 citation statements)

References 31 publications

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“…reported CPR, AR, and MPR in OD cycles to be 47%, 19%, and 35%, respectively. [ 16 ] These results are comparable to present study which showed CPR (50.2%), AR (21.8%), and MPR (32.5%). A systematic review by Thomopoulos et al .…”

Section: Discussionsupporting

confidence: 90%

Pregnancy outcomes and maternal and perinatal complications of pregnancies following in vitro fertilization/intracytoplasmic sperm injection using own oocytes, donor oocytes, and vitrified embryos: A prospective follow-up study

et al. 2016

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BACKGROUND:Several global studies have assessed maternal and perinatal outcomes and complications with the type of embryo transfer (ET) following in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). The present study assessed the incidence of maternal and perinatal outcomes and complications following IVF/ICSI associated with the type of embryo transferred.METHODOLOGY:A total of 2112 ETs were performed in 2092 female patients aged 21–50 years between January 1 and December 31, 2014 (Group A: Fresh ET using self-oocytes: 691; Group B: Fresh ET using donor oocytes: 810; and Group C: Thaw ET using vitrified-warmed embryos: 611).RESULTS:Incidence of clinical pregnancy rate, abortion rate, ectopic pregnancy rate, multiple pregnancy rate, live birth rate, and maternal complications was: Group A: 40.8%, 15.9%, 2.8%, 27.3%, 31.9%, and 17.7%; Group B: 50.2%, 21.8%, 1.6%, 32.5%, 36.9%, and 23.7%; and Group C: 42.9%, 25.2%, 1.1%, 31.3%, 29.6%, and 17.8%, respectively. Incidence of prematurity (<36 weeks of pregnancy), lower birth weight (<2500 g), perinatal mortality, and congenital abnormalities was as follows: Group A (29.52%, 36.2%, 5.22%, and 1.39%), Group B (42.58%, 46.2%, 4.6%, and 1.32%), and Group C (35.74%, 32.4%, 7.85%, and 0.94%), respectively.CONCLUSION:The higher incidence of the pregnancy outcomes in oocyte donation (OD) cycles can mainly be attributed to the younger age of oocyte donors. The higher incidence of complications in OD cycles could be due to advanced maternal age, different placentation, and immune tolerance.

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Section: Discussionsupporting

confidence: 90%

Pregnancy outcomes and maternal and perinatal complications of pregnancies following in vitro fertilization/intracytoplasmic sperm injection using own oocytes, donor oocytes, and vitrified embryos: A prospective follow-up study

et al. 2016

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“…No significant association was found between endometrial thickness and implantation rate but pregnancy outcome was improved in patients showing an endometrial lining thickness >8 mm. [16] Endometrial pattern in artificially prepared cycles does not influence pregnancy prognosis. [12]…”

Section: Discussionmentioning

confidence: 99%

A study of recipient related predictors of success in oocyte donation program

Gupta¹,

Banker²,

Patel³

et al. 2012

J Hum Reprod Sci

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BACKGROUND:Oocyte donation is an invaluable therapy for couples with impending or complete ovarian failure. In addition, oocyte donation affords a scientific opportunity to study the unique biologic participation of the uterus in the process of human embryo implantation.AIM:To identify the recipient variables that may have a significant impact on pregnancy outcome in order to optimize results of an oocyte donation program.DESIGN AND SETTINGS:A prospective study conducted from March 1, 2010 to March 31, 2011 at a private tertiary care IVF Clinic. Materials and methods A total of 270 recipients resulting in embryo transfer as a result of oocyte donation were enrolled. Clinical and Ongoing pregnancy rates, Implantation rates were calculated according to different age groups, Endometrial thickness, Indication, Day and number of embryos transferred. Data was evaluated as chi square analyses with comparative significance determined at P <.05.RESULTS:In recipients less than 40 years of age, higher ongoing pregnancy and implantation rates (41.9% and 24.6%) were seen as compared to recipients above 40 years (21.8% and 13.18%) respectively. Pregnancy and implantation rates increased with increasing endometrial thickness but the difference was not statistically significant. A higher ongoing pregnancy rate (40.9% vs.28.8%) and implantation rate (23% vs.19.6%) was demonstrated with Day 3 embryo transfer compared to Day 2 transfer.CONCLUSION:A declining endometrial receptivity may result in lower implantation and pregnancy rates in recipients above the age of 40 years, more pronounced after the age of 45 years. An endometrial thickness of >8 mm is considered ideal before transfer. Transfer of two selected embryos on day 3 yields a favorable pregnancy outcome with reduced multiple pregnancy rates. Recipient's age above 45 years has negative impact on pregnancy outcome whereas embryo transfers on Day 3 yields better pregnancy

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“…Several studies have reported that donor age is a predictive factor of live birth (LB) outcomes (3–10). Mirkin et al suggested that a baseline follicle stimulating hormone (FSH) between 4 and 8 IU/L was predictive of IVF outcomes (8). In contrast, Barton et al did not observe an association between FSH levels and LB outcomes (11), and observed that the total number of oocytes retrieved was associated with greatest probability of live birth (12).…”

Section: Introductionmentioning

confidence: 99%

Total number of oocytes and zygotes are predictive of live birth pregnancy in fresh donor oocyte in vitro fertilization cycles

Hariton

Kim

Palmor

et al. 2017

Fertility and Sterility

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Objective To evaluate the association of oocyte donor-recipient characteristics, oocyte donor response, and live birth pregnancy rate (LBR) following fresh donor oocyte IVF-embryo transfer (IVF-ET). Design Retrospective cohort study. Setting Academic reproductive medicine practice Patients Two hundred and thirty-seven consecutive fresh donor oocyte IVF-ET cycles from January 1, 2007 to December 31, 2013 at the Massachusetts General Hospital Fertility Center. Interventions None. Main Outcome Measure Live birth rate per cycle initiated Results The mean (± standard deviation) age of oocyte donors and recipients was 27.0 (± 3.7) and 41.4 (± 4.6) years, respectively. Oocyte donor demographic/reproductive characteristics, ovarian reserve testing, and peak serum estradiol during ovarian stimulation (OS) were similar among cycles which did and did not result in live birth (LB), respectively. Overall implantation, clinical pregnancy, and LBR per cycle initiated were 40.5%, 60.8%, and 54.9%, respectively. The greatest probability of LB was observed in cycles with >10 oocytes retrieved, mature oocytes, oocytes with normal fertilization (zygote-two pronuclear stage), and cleaved embryos, respectively. Conclusion The number of oocytes (total and mature), zygotes, and cleaved embryos are associated with LB following donor oocyte IVF cycles. These findings suggest that specific peri-fertilization factors may be predictive of pregnancy outcomes following donor oocyte IVF cycles.

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Cited by 37 publications

References 31 publications

Pregnancy outcomes and maternal and perinatal complications of pregnancies following in vitro fertilization/intracytoplasmic sperm injection using own oocytes, donor oocytes, and vitrified embryos: A prospective follow-up study

Pregnancy outcomes and maternal and perinatal complications of pregnancies following in vitro fertilization/intracytoplasmic sperm injection using own oocytes, donor oocytes, and vitrified embryos: A prospective follow-up study

A study of recipient related predictors of success in oocyte donation program

Total number of oocytes and zygotes are predictive of live birth pregnancy in fresh donor oocyte in vitro fertilization cycles

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