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Abstract

A nasal solution formulation of the cationic material chitosan was shown to greatly enhance the absorption of insulin across the nasal mucosa of rat and sheep. The absorption promoting effect was concentration dependent with the optimal efficacy obtained for concentrations higher than 0.2% and 0.5% in rats and sheep, respectively. The absorption promoting effect was reversible with time in a "pulse-chase" study. Histological examination of the nasal mucosa of rats exposed to a chitosan solution for 60 minutes showed little change.

Quitosana: biopolímero funcional com potencial industrial biomédico

“…Este problema pode ser solucionado pela combinação da morfina com quitosana, um material bioadesivo que torna lenta a depuração mucociliar da morfina, permitindo mais tempo para absorção. 90,124 Este sistema de liberação morfina-quitosana pode ser particularmente de grande benefício aos pacientes que fazem tratamento domiciliar. 123 A quitosana tem demonstrado melhorar as propriedades de dissolução e a biodisponibilidade de fármacos pouco solúveis.…”

Influence of Piperine on Transcutaneous Permeation of Repaglinide in Rats and on Tight Junction Proteins in HaCaT Cells: Unveiling the Mechanisms for Enhanced Permeation

“…The tight junctions (TJ) of Caco-2 cells are reported to be influenced by chitosan (CTN) due to structural reorganization of the TJ proteins zona occludin (ZO-1) and occludin [11,12]. TJs are dynamic structures with multi-protein complexes consisting of trans-membrane proteins (claudins, occludin, junctional adhesion molecules) and TJ plaque proteins (ZO-1, ZO-2, ZO-3, cingulin, symplekin).…”

Stimulation of Mucosal and Systemic Antibody Responses against Recombinant Transferrin-binding Protein B of Actinobacillus pleuropneumoniae with Chitosan after Tracheal Administration in Piglets

“…Compared with other natural polysaccharides, chitosan has high biodegradability, low toxicity, and bioadhesive properties and is neither an irritant nor an allergen in humans [25]. Toxicological studies have shown that chitosan is non-toxic both locally in terms of its interaction with the nasal membrane and systemically with the body as a whole [13]. Therefore, chitosan might have an 'adjuvant' effect on immune response either by increasing the contact time of the various antigens with the relevant tissue and/or by increasing the rate of transport across the membrane, which can provide better presentation of the antigens to the immune cells of the mucosal epithelial and nasal-associated lymphoid tissue (NALT) [14].…”