Yy Syndrome With Multiple Malformations

Males with an XYY sex chromosome complement.

“…Both were testes. The authors described this patient as a 46,XY/47,XYY/47,XXY Undescended testes, mentally subnormal Kosenow andPfeiffer (1966, 1967) 16 64 Hypogonadism Balodimos et al (1966) Identified family study: fertile Thompson, Melnyk, and Hecht (1967) 23 24 Neck webbing: mental subnormality, normal sexual development Kelly et al (1967) 24 8 Admitted psychiatric unit with destructive, defiant, antisocial behaviour; Turner (personal communication, 1968) reported by Turner and Jennings (1961) Franks et al (1967), was most thoroughly studied and consequently is all the more valuable. The patient was a mentally retarded female of 21 months of age when first examined.…”

XYY sex chromosomes in a Jamaican with orthopaedic abnormalities.

“…The pattern of labelling appears to vary; in some cells both the Y chromosomes were labelled, in others only one. Balodimos et al (1966) and Kikuchi and Sandberg (1965) found that the majority of cells showed synchronous labelling of the 2 Ys, whereas Kosenow and Pfeiffer (1966) reported discordant labelling. Both, however, found that they labelled more heavily and later than the G autosomes.…”

“…Spermatogenesis is, therefore, the most likely source of the error. We therefore examined the paternal age of all the patients in Table I, where given, and those in the cases of Dunn et al (1961), Vignetti et al (1964), Verresen and van den Berghe (1965), and Kosenow and Pfeiffer (1966), to see if there was any suggestion of a significant increase over the normal.…”

Dermatoglyphic studies of the 47, XYY male

“…The 47,XYY individual does not show any consistent physical features or characteristic malformations (Kosenow & Pfeiffer 1966), except usually having an adult height greater than that of his parents (Borgaonkar et al 1972). An extra Y chromosome has been reported in males with radioulnar synostosis (Cleveland et al 1969, Elbualy 1969, pectus excavatum , hypertelorism (Abrams & Pergament 1971), talipes equinovarus (Court Brown et al 1964), idiopathic osteoarthropathy (Tzoneva-Maneva et al 1966), genital abnormalities (Balodimos et al 1966, Elbualy 1969, Franks et al 1967, Thorburn et al 1968, Vignetti et al 1964, neurological abnormalities (Daly 1969), congenital cyanotic heart disease (Price 1968), acne (Hustinx & van Olphen 1963, Telfer et al 1968), gynecomastia (Balodimos et al 1966, Voorhees et al 1970, mental retardation , Kelly et al 1967, and various other abnormalities (Forssman 1967, Hustinx & van Olphen 1963, Kelly et al 1967, Kosenow & Pfeiffer 1966, Richards & Stewart 1966, Tannoia et al 1970, Telfer et al 1968. Some clinically normal individuals have also been reported (Borgaonkar et al 1968, Sandberg et al 1961, Stenchever & Macintyre 1969, Wilton & Lever 1967.…”